Results 51 to 60 of about 3,822,401 (336)

The drivers of antibiotic use and misuse: the development and investigation of a theory driven community measure

BMC Public Health, 2019
Background Antimicrobial resistance is a global public health concern, with extensive associated health and economic implications. Actions to slow and contain the development of resistance are imperative.
Mitchell K. Byrne, Sebastien Miellet, Anica McGlinn, Janaye Fish, Shahla Meedya, Nina Reynolds, Antoine M. van Oijen   +6 more
doaj   +1 more source

Mechanisms of antimicrobial resistance in biofilms

npj Antimicrobials and Resistance
Most bacteria in nature exist in aggregated communities known as biofilms, and cells within a biofilm demonstrate major physiological changes compared to their planktonic counterparts. Biofilms are associated with many different types of infections which
Ho Yu Liu, Emma L. Prentice, Mark A. Webber   +2 more
semanticscholar   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Unveiling the Rare: Sternoclavicular Joint Brucellosis Osteomyelitis—A Case Report and Literature Review

Case Reports in Infectious Diseases
Brucellosis, an endemic zoonotic infection, often presents with musculoskeletal complications, but sternoclavicular joint (SCJ) osteomyelitis is exceptionally rare.
Farhang Babamahmoodi, Rana Kolahi Ahari, Abdolreza Babamahmoodi, Tahereh Zareie   +3 more
doaj   +1 more source

Mobile Genetic Elements Associated with Antimicrobial Resistance

Clinical Microbiology Reviews, 2018
Strains of bacteria resistant to antibiotics, particularly those that are multiresistant, are an increasing major health care problem around the world.
S. Partridge, S. Kwong, N. Firth, S. Jensen   +3 more
semanticscholar   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Roving methyltransferases generate a mosaic epigenetic landscape and influence evolution in Bacteroides fragilis group

Nature Communications, 2023
Three types of DNA methyl modifications have been detected in bacterial genomes, and mechanistic studies have demonstrated roles for DNA methylation in physiological functions ranging from phage defense to transcriptional control of virulence and host ...
Michael J. Tisza, Derek D. N. Smith, Andrew E. Clark, Jung-Ho Youn, NISC Comparative Sequencing Program, Pavel P. Khil, John P. Dekker   +6 more
doaj   +1 more source

Efflux-mediated antimicrobial resistance [PDF]

Journal of Antimicrobial Chemotherapy, 2005
Antibiotic resistance continues to plague antimicrobial chemotherapy of infectious disease. And while true biocide resistance is as yet unrealized, in vitro and in vivo episodes of reduced biocide susceptibility are common and the history of antibiotic resistance should not be ignored in the development and use of biocidal agents.
openaire   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source