Results 51 to 60 of about 42,192 (254)

National Facilitators and Barriers to the Implementation of Incentives for Antibiotic Access and Innovation

Antibiotics, 2021
Prominent reports have assessed the challenges to antibiotic innovation and recommended implementing “pull” incentives, i.e., mechanisms that give increased and predictable revenues for important, marketed antibiotics. We set out to understand countries’
Christine Årdal, Yohann Lacotte, Suzanne Edwards, Marie-Cécile Ploy, on behalf of the European Union Joint Action on Antimicrobial Resistance and Healthcare-Associated Infections (EU-JAMRAI)   +4 more
doaj   +1 more source

Strategic approach for combating antimicrobial resistance (AMR)

Global Health & Medicine, 2019
During the past 70 years, there has been a continued incremental worsening of antimicrobial resistance (AMR) by a combination of abusing antimicrobials in humans and animals as well as insufficient research and investment for new antimicrobial agents.
openaire   +3 more sources

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

Bioluminescent Pseudomonas aeruginosa and Escherichia coli for whole-cell screening of antibacterial and adjuvant compounds

Scientific Reports
Continued efforts to discover new antibacterial molecules are critical to achieve a robust pre-clinical pipeline for new antibiotics. Screening of compound or natural product extract libraries remains a widespread approach and can benefit from the ...
Eszter Farkas, Geoffrey A. McKay, Lin Tao Hu, Mina Nekouei, Peying Ho, Wilfried Moreira, Chia Ching Chan, Linh Chi Dam, Karine Auclair, Samantha Gruenheid, Lyle Whyte, Peter Dedon, Dao Nguyen   +12 more
doaj   +1 more source

Genomic and Epidemiological Evidence of a Dominant Panton-Valentine Leucocidin-Positive Methicillin Resistant Staphylococcus aureus Lineage in Sri Lanka and Presence Among Isolates From the United Kingdom and Australia

Frontiers in Cellular and Infection Microbiology, 2019
Objective: To undertake the first detailed genomic analysis of methicillin-resistant Staphylococcus aureus (MRSA) isolated in Sri Lanka.Methods: A prospective observational study was performed on 94 MRSA isolates collected over a 4 months period from the
Sharla M. McTavish, Sarah J. Snow, Ellie C. Cook, Bruno Pichon, Sarah Coleman, Geoffrey W. Coombs, Stanley Pang, Cesar A. Arias, Cesar A. Arias, Cesar A. Arias, Lorena Díaz, Lorena Díaz, Emma Boldock, Emma Boldock, Steve Davies, Mangala Udukala, Angela Marie Kearns, Sisira Siribaddana, Sisira Siribaddana, Thushan I. de Silva, Thushan I. de Silva   +20 more
doaj   +1 more source

Gonococcal resistance can be viewed productively as part of a syndemic of antimicrobial resistance: an ecological analysis of 30 European countries

Antimicrobial Resistance and Infection Control, 2020
Background It is unclear how important bystander selection is in the genesis of antimicrobial resistance (AMR) in Neisseria gonorrhoeae. Methods We assessed bystander selection in a novel way. Mixed-effects linear regression was used to assess if country-
Chris Kenyon, Sheeba S. Manoharan-Basil, Christophe Van Dijck   +2 more
doaj   +1 more source

A Solution for Exosome‐Based Analysis: Surface‐Enhanced Raman Spectroscopy and Artificial Intelligence

Advanced Intelligent Discovery, EarlyView.
Exosomes are emerging as powerful biomarkers for disease diagnosis and monitoring. This review highlights the integration of surface‐enhanced Raman spectroscopy with artificial intelligence to enhance molecular fingerprinting of exosomes. Machine learning and deep learning techniques improve spectral interpretation, enabling accurate classification of ...
Munevver Akdeniz, Zakarya Al‐Shaebi, Omer Aydin   +2 more
wiley   +1 more source

Opportunities for Laboratory Testing to Inform Antimicrobial Use for Bovine Respiratory Disease: Application of Information Quality Value Stream Maps in Commercial Feedlots

Antibiotics
Background/Objectives: The implementation of information quality value stream maps (IQ-VSMs) in food animal production systems can increase our understanding of the opportunities and challenges when using laboratory testing for antimicrobial resistance ...
Simon J. G. Otto, Colleen M. Pollock, Jo-Anne Relf-Eckstein, Lianne McLeod, Cheryl L. Waldner   +4 more
doaj   +1 more source

Determinants of Antimicrobial Resistance among the Different European Countries: More than Human and Animal Antimicrobial Consumption

Antibiotics, 2021
Although antimicrobial consumption is considered the main driver of antimicrobial resistance (AMR), other factors probably have a significant but less studied impact.
Ana C. Silva, Paulo Jorge Nogueira, José-Artur Paiva   +2 more
doaj   +1 more source

The role of vaccines in combating antimicrobial resistance (AMR) bacteria

Saudi Journal of Biological Sciences, 2021
Most pathogens have developed an intrinsic capacity to thrive by developing resistance to antimicrobial compounds utilized in treatment. Antimicrobial resistance arises when microbial agents such as bacteria, viruses, fungi, and parasites alter their behaviour to make current conventional medicines inefficient.
openaire   +2 more sources