Results 191 to 200 of about 251,321 (315)

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Antimicrobial Resistance and ESBL-Associated Predictors Among Uropathogens: A 2019-2024 Isolate-Level Study. [PDF]

Antibiotics (Basel)
Ene RL, Popescu R, Cobec AE, Puscasiu D, Ene IA, Vlad DC, Cobec IM, Seropian P.   +7 more
europepmc   +1 more source

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Awareness and practices regarding antimicrobial resistance among livestock farmers in Northern Uganda. [PDF]

Front Antibiot
Kato JD, Lamaro PO, Waiswa JP, Madraa G, Otika D, Okello MO, Ebbs DS, Pebolo PF, Bongomin F.   +8 more
europepmc   +1 more source

Migration crisis in Venezuela and its impact on HIV in other countries: the case of Colombia

Annals of Clinical Microbiology and Antimicrobials, 2019
Alfonso J. Rodríguez-Morales, D. Katterine Bonilla-Aldana, Miguel Morales, José A. Suárez, Ernesto Martínez-Buitrago   +4 more
doaj   +1 more source

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source

Treatment of contagious bovine pleuropneumonia as a potential driver for antimicrobial resistance in pastoral production systems of Kenya. [PDF]

Sci Rep
M Akoko J, Okumu NO, Makumi A, Muloi D, Abkallo HM, Wesonga H, Chebore W, Masiga J, Nguka G, Schieck E, Mulongo MM.   +10 more
europepmc   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Albumin and Other Plasma Proteins in Pediatric Patients: What, When, and How Much They Influence Antimicrobial Pharmacology. [PDF]

J Pediatr Pharmacol Ther
Angelini J, Russiani F, Ferin S, Flammini S, Tascini C, Roberts JA, Baraldo M, Giuliano S.   +7 more
europepmc   +1 more source

Farm-economic analysis of reducing antimicrobial use whilst adopting good management strategies on farrow-to-finish pig farms [PDF]

, 2015
Dewulf, Jeroen, Hogeveen, Henk, Lauwers, Ludwig, Postma, Merel, Rojo Gimeno, Cristina, Wauters, Erwin   +5 more
core   +1 more source