Results 71 to 80 of about 1,021 (176)

Differential gene expression analysis in antimony-unresponsive Indian kala-azar (visceral leishmaniasis) clinical isolates by DNA microarray

, 2007
In this study, cDNA microarray analysis of a closely related species, Leishmania major, was used as a screening tool to compare antimonial-resistant and susceptible clinical isolates of Leishmania donovani in order to to identify candidate genes on the ...
Mandal, S. K., Mandal, G., Chatterjee, M., Almeida, R., Singh, N., Kumar, P., Venkatachalam, S., Govind, M. K., Kothari, H., Sundar, S.   +9 more
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Efficacy of sodium antimony gluconate and ketoconazole in the treatment of kala-azar--a comparative study.

The Journal of communicable diseases, 1997
The present study was undertaken to determine the efficacy of ketoconazole in comparison to sodium antimony gluconate (SAG) in the treatment of kala-azar. The study was conducted at two centres: All India Institute of Medical Science, New Delhi and Calcutta School of Tropical Medicine, Calcutta.
J P, Wali, P, Aggarwal, A, Nandy, S, Singh, M, Addy, S K, Guha, S N, Dwivedi, M G, Karmarkar, A K, Maji   +8 more
openaire   +1 more source

Dendritic Cell-Based Immunotherapy Combined with Antimony-Based Chemotherapy Cures Established Murine Visceral Leishmaniasis

, 2003
Dendritic cells (DCs) have been proposed to play a critical role as adjuvants in vaccination and immunotherapy. In this study we evaluated the combined effect of soluble Leishmania donovani Ag (SLDA)-pulsed syngeneic bone marrow-derived DC-based ...
Mandal, Labanya, Maitra, Sudipta, Ghosh, Monidipa, Bandyopadhyay, Santu, Pal, Chiranjib, Ray, Mitali   +5 more
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Ubiquitin conjugation of open reading frame F DNA vaccine leads to enhanced cell-mediated immune response and induces protection against both antimony-susceptible and -resistant strains of Leishmania donovani

, 2009
Resistance of Leishmania donovani to sodium antimony gluconate has become a critical issue in the current, prolonged epidemic in India. Hence, there is an urgent need for a vaccine that is protective against both antimony-susceptible and -resistant ...
Ankur Sharma, Sharma, Ankur, Rentala Madhubala, Madhubala, Rentala   +3 more
core   +1 more source

Drug policy for visceral leishmaniasis: a cost-effectiveness analysis.

, 2007
OBJECTIVE: To facilitate the choice of the best visceral leishmaniasis (VL) treatment strategy for first-line health services in (VL)-endemic areas, we compared in a formal decision analysis the cost and the cost-effectiveness of the different available ...
Diap, G, Gerstl, S, Boelaert, M, Van der Stuyft, P, V. Vanlerberghe, Guerin, P J, P. Van der Stuyft, S. Gerstl, Meheus, F, P. J. Guerin, Vanlerberghe, V, G. Diap, F. Meheus, Van Der Stuyft, Patrick, M. Boelaert, Guerin, PJ   +15 more
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Antimony-Resistant Clinical Isolates of Leishmania donovani Are Susceptible to Paromomycin and Sitamaquine

, 2011
Widespread antimonial resistance in anthroponotic visceral leishmaniasis (VL) makes it critical to monitor the susceptibility of prevailing field isolates to upcoming antileishmanials in order to frame the right treatment policies to protect these drugs ...
Dhiraj Kumar, Narender Singh Negi, Poonam Salotra, Ruchi Singh, Arpita Kulshrestha   +4 more
core   +1 more source

Profile of Kala-azar in North India

, 1991
One hundred twenty-nine cases of visceral leishmaniasis (kala-azar)seen over a thirteen year period in a nonendemic area at a referral medical center in north India are described.
Praveen Aggarwal, Jyoti Prakash Wali
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Antileishmanial effect of 3-aminooxy-1-aminopropane is due to polyamine depletion.

, 2007
The polyamines putrescine, spermidine, and spermine are organic cations that are required for cell growth and differentiation. Ornithine decarboxylase (ODC), the first and rate-limiting enzyme in the polyamine biosynthetic pathway, catalyzes the ...
Singh, Sushma, Heby, Olle, Khomutov, Alex R., Mukherjee, Angana, Persson, Lo, Khomutov, Alex R, Chatterjee, Mitali, Madhubala, Rentala   +7 more
core   +2 more sources

Pharmacovigilance in kala-azar patients with severe thrombocytopenia caused by sodium antimony gluconate & miltefosine.

The Indian journal of medical research, 2007
Sodium antimony gluconate (SAG) and miltefosine used in the treatment of kala-azar are known to cause several side effects but severe thrombocytopenia has not been reported. Four cases of severe thrombocytopenia, two caused by SAG and two by miltefosine were promptly detected and treated by immediate withdrawal of the offending drugs, platelet and ...
C P, Thakur, A, Kumar, G, Mitra, S, Thakur, M, Thakur   +4 more
openaire   +1 more source

CLINICAL AND INFECTIVE OUTCOME OF PARASITOLOGICALY CONFIRMED KALA-AZAR PATIENTS TREATED WITH SODIUM ANTIMONY

, 2014
A total of fifty consecutive cases of Kala-azar admitted in the medicine units of Rajshahi Medical College Hospital during the period from February 2006 to October 2006 were included in this study.
Mahmudur Rahman Siddiqui, Ahmed Hossain
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