Results 81 to 90 of about 1,021 (176)

Comparison of treatment regimens of kala-azar based on culture & sensitivity of amastigotes to sodium antimony gluconate.

The Indian journal of medical research, 2008
Present treatment strategies for kala-azar (visceral leishmaniasis, VL) include use of first line drug sodium antimony gluconate (SAG) to all patients but a large number of patients do not get relief with this drug. If a patient does not respond to a full course of SAG, a second or third line drug is given.
C P, Thakur, Shabnam, Thakur, S, Narayan, Arun, Sinha   +3 more
openaire   +1 more source

Novel mechanism of drug resistance in kala azar field isolates

, 2003
Clinical resistance to pentavalent antimonial drugs in the form of sodium antimony gluconate (SAG) has become a major problem in the treatment of kala azar (visceral leishmaniasis) in India.
Singh, Neeloo, Singh, Ramsing Th., Sundar, Shyam   +2 more
core   +1 more source

Therapeutic trial of sodium antimony gluconate alone and in combination with ketoconazole in post-kala-azar dermal leishmaniasis.

Indian journal of dermatology, venereology and leprology, 2007
Drugs used in PKDL include parenteral sodium antimony gluconate (SAG), amphotericin-B, pentamidine, and ketoconazole (KTZ). SAG is the most effective one. Given alone, SAG has to be given for a long duration, leading to poor patient compliance and treatment failure.
S. K. Rathi, R. K. Pandhi, N. Khanna, P. Chopra   +3 more
openaire   +1 more source

Immunomodulatory effects of antileishmanial drugs

, 2013
The commonly used antileishmanial drugs are sodium antimony gluconate (SAG), amphotericin B, miltefosineandparomomycin. Thereareanumberof reports that antileishmanial drugsshowimmunomodulatory properties.
Roy, Syamal, Ghosh, Moumita, Roy, Koushik   +2 more
core   +1 more source

Distribution of IgG subclasses in antimonial unresponsive Indian kala-azar patients

, 1998
Sodium antimony gluconate (SAG) is the mainstay of treatment for visceral leishmaniasis (VL) or kala-azar. In view of the increasing incidence of refractoriness to SAG in India, we compared the levels of parasite-specific IgG and IgG subclasses in 20 ...
Saha, S. K., Chatterjee, M., Basu, D., Basu, K., Pramanik, N., Mandal, C., Goswami, R. P., Guha, S. K., Bannerjee, D.   +8 more
core   +1 more source

Takayasu Arteritis Coexisting with Cutaneous Leishmaniasis. [PDF]

J Clin Med, 2023
Zhao M, Liu Y, Hu Z, Sun J, Yang Z, Wei L, Xu Z, Ma L.   +7 more
europepmc   +1 more source

Effect of sodium stibogluconate in recruiting and awakening immune cells in the pleural fluid of pancreatic cancer: preparation for immunotherapy. [PDF]

Front Immunol, 2023
Yu B, Jing P, Gao F, Zhang P, Zheng G, Zhang X.   +5 more
europepmc   +1 more source

Novel Betulin Derivatives as Antileishmanial Agents with Mode of Action Targeting Type

, 2011
M. Unlike CPT, these compounds do not stabilize the cleavage complex, rather they abrogate the covalent complex formation. In processive mode of relaxation assay condition, these compounds slow down the strand rotation event, which ultimately affect the ...
Tulika Mukherjee, Sayan Chowdhury, Somenath Souvik Sengupta, Hemanta K Majumder, Sibabrata Mukhopadhyay, Roy Chowdhury   +5 more
core  

Research note: Antileishmanial activity of drug infused mini-agar plates on Leishmania donovani promastigotes

, 2010
Drug infused mini agar plates were found to be a better alternative of broth dilution method in the determination of antileishmanial susceptibility of two commonly used drugs, Sodium antimony gluconate and Amphotericin B against Leishmania donovani ...
ABRIZAH BINTI ABDULLAH
core  

NMR spectroscopic evidence that the antileishmanial drug sodium stibogluconate comprises one predominant molecular species. [PDF]

J Inorg Biochem
Lance-Byrne A, Gee JC, Johnstone TC.
europepmc   +1 more source