Results 251 to 260 of about 21,172,428 (334)

Cathepsin K Inhibition Alleviates Antimycin-Induced Cardiomyocyte Apoptosis

Dawn Anne Davison
openalex   +2 more sources

Mitigating Dexamethasone‐Induced Muscle Wasting and Mitochondrial Impairment in Mice on a High‐Fat and High‐Sucrose Diet With Peanut Sprout Extract

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Peanut sprout extract (PSE) significantly attenuated skeletal muscle atrophy induced by a high‐fat, high‐sucrose diet and dexamethasone, improving muscle strength and reducing triglyceride accumulation and inflammation. It enhanced mitochondrial function by upregulating TFAM and OXPHOS proteins and partially restoring PGC1α expression.
Sang‐Mi Jo, Thi My Tien Truong, Hyun‐Jin Jang, Ji Hee Lim, Inhae Kang   +4 more
wiley   +1 more source

Evolutionary engineering and molecular characterization of an antimycin A-resistant Saccharomyces cerevisiae strain: the key role of pleiotropic drug resistance (PDR1). [PDF]

FEMS Yeast Res
Topaloğlu A, Holyavkin C, Esen Ö, Morkoç O, Persson K, Geijer C, Çakar ZP.   +6 more
europepmc   +1 more source

C9orf72 Repeat Expansion Induces Metabolic Dysfunction in Human iPSC‐Derived Microglia and Modulates Glial‐Neuronal Crosstalk

Glia, Volume 74, Issue 1, January 2026.
C9orf72 microglia display heightened glycolysis and oxidative stress, driving astrocytic reprogramming that impacts motor neurons. iPSC tricultures uncover key glial–neuronal interactions in C9orf72 pathology. ABSTRACT The C9orf72 hexanucleotide repeat expansion mutation is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and ...
Marika Mearelli, Insa Hirschberg, Christin Weissleder, Carmela Giachino, María José Pérez, Malvina Dubroux, Francesca Provenzano, Mafalda Rizzuti, Linda Ottoboni, Udit Sheth, Tania F. Gendron, Stefania Corti, Michela Deleidi   +12 more
wiley   +1 more source

Structural and functional modulation of human kynurenine aminotransferase I enhances selenium-driven redox metabolism for cancer therapy. [PDF]

Redox Biol
Selvam AK, Sun R, Sandalova T, Salter H, Achour A, Björnstedt M.   +5 more
europepmc   +1 more source

Lipoic Acid Ameliorates Lipopolysaccharide‐Induced Inflammation via Inhibition of Glycolysis in RAW264.7 Macrophages

Immunity, Inflammation and Disease, Volume 14, Issue 1, January 2026.
Anti‐inflammatory mechanism of Lipoic acid. LA and siRNA‐HIF1α inhibited the expression of HIF1α and inflammatory factors such as IL‐6, IL‐18, TNF‐α, and IL‐1β in LPS‐induced macrophages. The researchers showed in this work that the anti‐inflammation was achieved through HIF1α/glycolysis axis.
Liduo Yue, Kai Wang, Rongyuan Wang, Linbei Lu, Lihong Fan   +4 more
wiley   +1 more source

Dysregulation of apolipoprotein o reprograms CCR7⁺CD4⁺T cell fate in primary autoimmune thrombocytopenia. [PDF]

iScience
Li T, Li X, Huang H.
europepmc   +1 more source

Efzimfotase Alfa Improves Respiratory Capacity in Muscle Tissue From a Mouse Model of HPP

JIMD Reports, Volume 67, Issue 1, January 2026.
ABSTRACT Hypophosphatasia (HPP) is an inherited metabolic disease caused by deficient tissue‐nonspecific alkaline phosphatase (ALP) activity and characterized by skeletal and nonskeletal symptoms, including muscle weakness and fatigue. We hypothesized that mitochondrial respiration is impaired in muscle in HPP, independent of skeletal manifestations ...
Denise Devore, Juan Ruanova, Walter Voegtli, Derek Dunn, John Decker, Maurizio Mazzantini, Vincenzo De Tata, Maria Concetta Scavuzzo, Francesco Conti, Anna Petryk, Maria Luisa Brandi   +10 more
wiley   +1 more source

Defined metabolic states shape T cell fate and function across culture conditions. [PDF]

Front Immunol
Sylvester K, Karassina N, Lauer AC, Vidugiris G, Vidugiriene J.   +4 more
europepmc   +1 more source

Monkeypox Virus: Epidemiology, Virology, Diagnosis, Vaccine, and Therapeutics

MedComm, Volume 7, Issue 1, January 2026.
This review provides a comprehensive overview of the latest research advances in MPXV, with a focused analysis across five core dimensions: epidemiology, virology, diagnosis, vaccine, and therapeutics. The primary objective of this review is to advance the understanding of MPXV and facilitate the development of more effective diagnostic methods ...
Yunzheng Yan, Yaqin Sun, Guangyan Sun, Cheng Niu, Xinyuan Zhao, Ming Zhao, Tongyao Liu, Suyue Zhang, Hui Zhai, Ankang Liu, Shouzhi Yu, Shuyuan Pan, Wu Zhong, Yuntao Zhang, Song Li   +14 more
wiley   +1 more source