A Multi-Objective Approach for Anti-Osteosarcoma Cancer Agents Discovery through Drug Repurposing [PDF]
, 2020 [Abstract] Osteosarcoma is the most common type of primary malignant bone tumor. Although nowadays 5-year survival rates can reach up to 60–70%, acute complications and late effects of osteosarcoma therapy are two of the limiting factors in treatments ...
Cabrera-Andrade, Alejandro +7 more
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Review on Defensive Roles of Thymoquinone Nanobiosensoring Prospective in Opposition to Cancer [PDF]
, 2021 Thymoquinone (TQ), the most important bioactive constituent of Nigella sativa, has been originating to exhibit anticancer effects in plentiful preclinical studies.
Dr. A. Mohamed Sikkander +1 more
core +2 more sources
Evidence-Based Complementary and Alternative Medicine, Volume 2013, Issue 1, 2013., 2013 Decursin (D), purified from Angelica gigas Nakai, has been proven to exert neuroprotective property. Previous study revealed that D reduced Aβ25‒35‐induced cytotoxicity in PC12 cells. Our study explored the underlying mechanisms by which D mediates its therapeutic effects in vitro. Pretreatment of cells with D diminished intracellular generation of ROS
Li Li +6 more
wiley +1 more source
Radical scavenging and antimicrobial activity of essential oil and extracts of Echinophora sibthorpiana Guss. from Macedonia [PDF]
, 2014 This study was undertaken to determine the antioxidant and antimicrobial effect of essential oil and extracts of Echinophora sibthorpiana Guss. (fam. Apiaceae) collected in Macedonia. The chemical composition of E. sibthorpiana essential oil was
Džamić Ana +6 more
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Evidence-Based Complementary and Alternative Medicine, Volume 2013, Issue 1, 2013., 2013 Syzygium polyanthum (Wight) Walp. var. polyanthum leaves are consumed as a traditional Malay treatment of hypertension. This study investigates hypotensive potential of aqueous (AESP) and residual methanolic (met‐AESP) extracts of S. polyanthum leaves and possible involvement of autonomic receptors.
A. Ismail +4 more
wiley +1 more source
Monepantel is a non-competitive antagonist of nicotinic acetylcholine receptors from Ascaris suum and Oesophagostomum dentatum [PDF]
, 2018 Zolvix (R) is a recently introduced anthelmintic drench containing monepantel as the active ingredient. Monepantel is a positive allosteric modulator of DEG-3/DES-2 type nicotinic acetylcholine receptors (nAChRs) in several nematode species. The drug has
Abongwa, Melanie +6 more
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Functional Characterization of a Novel Family of Acetylcholine-Gated Chloride Channels in Schistosoma mansoni [PDF]
, 2014 Acetylcholine is the canonical excitatory neurotransmitter of the mammalian neuromuscular system. However, in the trematode parasite Schistosoma mansoni, cholinergic stimulation leads to muscle relaxation and a flaccid paralysis, suggesting an inhibitory
Buxton, S. +5 more
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Interaction of carvacrol with the Ascaris suum nicotinic acetylcholine receptors and gamma-aminobutyric acid receptors, potential mechanism of antinematodal action [PDF]
, 2015 Essential plant oils (or their active principles) are safe to use and a potentially attractive alternative to current antiparasitic drugs. In the present study, we tested the effects of carvacrol on the isolated tissues of Ascaris suum and investigated ...
Marjanović, Đorđe +4 more
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Pharmacological characterization of a homomeric nicotinic acetylcholine receptor formed by Ancylostoma caninum ACR-16 [PDF]
, 2018 Parasitic nematode infections affect millions of people worldwide and are a significant cause of human and veterinary disease. Chronic infections cause debilitating health problems in humans, domestic animals, and livestock.
Musselman, Nicole
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DECOCTION OF POMEGRANATE (PUNICA GRANATUM L.) PEEL AS AN ANTHELMINTIC AGAINST TAENIA SAGINATA [PDF]
, 2021 Objective: The purpose of this study was to investigate the anthelmintic activity of pomegranate (Punica granatum L.) peel decoction against Taenia saginata. Methods: The in vitro assay was conducted by observing the motility of T.
MUSTARICHIE, RESMI, SAPTARINI, NYI MEKAR
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