Results 91 to 100 of about 13,105 (210)

Real-world pharmacovigilance study of drug-induced diabetes insipidus from the FAERS database. [PDF]

Endocr Connect
Lv H, Wu Y, Lan L, Shen N.
europepmc   +1 more source

Targeting Cell Cycle Vulnerabilities in Cancers: Emerging Strategies for Therapeutic Development

Cancer Science, EarlyView.
Dysregulated cell cycle control often involves alternative compensatory pathways in cancers to maintain its robustness but provide unique targetable vulnerabilities. We overview recent insights on cancer‐specific vulnerabilities across the cell cycle and discuss how these can be used to develop new therapeutic strategies.
Nana Kamakura, Minji Jo, Motoko Takahashi, Toru Hirota   +3 more
wiley   +1 more source

Impact of Nutritional Supplements and Antioxidants in the Treatment of Breast Cancer: A Systematic Review. [PDF]

Nutrients
Uribe-Ramírez D, Laguna-Maldonado KD, Vázquez-Carrada M, Cortés-Peña LF, Vilchis-Landeros MM, Vázquez-Meza H, Matuz-Mares D.   +6 more
europepmc   +1 more source

Hypericin Suppresses Liver Cancer Through Autophagic Degradation of AKT and Eliciting Antitumor Immune Response

Cancer Science, EarlyView.
Hypericin induces autophagic AKT degradation by promoting AKT‐HSPA5 interaction in an S473 phosphorylation‐dependent manner, suppressing HCC growth. It enhances CD8+ T cell‐mediated antitumor immunity and synergizes with anti‐PD‐L1 therapy, showing favorable safety for HCC treatment. ABSTRACT Hepatocellular carcinoma (HCC) is the most prevalent primary
Sien Ma, Qianqian Xu, Mengjuan Zhu, Xianming Ge, Jian Xu, Yan Pan, Mengli Wang, Yuting Zhu, Aoxuan Xu, Hanmeng Liu, GuangHai Xiang, Weipeng Gong, Bao Zhao   +12 more
wiley   +1 more source

Retreatment with aromatase inhibitor therapy in the management of granulosa cell tumor

Gynecologic Oncology Reports, 2016
Melissa Schwartz, Gloria S. Huang
doaj   +1 more source

Reported drug spectrum and disproportionality signals for malignant neoplasm progression in FAERS: a real-world pharmacovigilance study. [PDF]

Front Pharmacol
Liu Y, Zeng M, Zhang M, Xu H, Li X, Zhang J.   +5 more
europepmc   +1 more source

A Curcumin‐Derived HSP70 Inhibitor Disrupts Lysosomal Function to Suppress Triple‐Negative Breast Cancer Progression

Cell Proliferation, EarlyView.
Novel curcumin‐derived M4 binds HSP70's ATPase domain, disrupting HSP70‐mediated lysosomes‐autophagy pathway to inhibit TNBC growth and metastasis, and synergizes with paclitaxel for potent combination therapy. ABSTRACT Structural modification of curcumin yielded a novel series of 1,4‐pentadien‐3‐one oxime ether derivatives, among which compound M4 ...
Zijian Li, Wanxia Wang, Yuxin Zhou, Tao Zeng, Jian Liu, Yingjie Qing, Xuan Han   +6 more
wiley   +1 more source

Guidance on calculating doses of antineoplastic agents for transgender and gender-expansive patients taking gender-affirming hormone therapy

JAPhA Pharmacotherapy
Andréa C. LeVoir, Erica C. Stumpf, Wiktoria Bogdanska, Maly Fenelus, Ilya G. Glezerman, Lubaina Presswala, Boglarka Gyurkocza, Koshy Alexander, Kelly Haviland   +8 more
openaire   +1 more source

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

Reproductive and sexual sequelae of neuroendocrine tumour therapies: an under-recognised challenge. [PDF]

Endocr Relat Cancer
Shekhda KM, Shah PM, Biddanda A, Grossman A, Caplin M.   +4 more
europepmc   +1 more source