Results 141 to 150 of about 13,105 (210)

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, Volume 13, Issue 38, 9 July 2026.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Endocrine Therapy for Endometrial Carcinoma: Current Evidence, Resistance Mechanisms, and Biomarker-Driven Patient Selection. [PDF]

Curr Oncol
Yamanaka T, Yoshida H, Shimoi T, Sudo K, Yonemori K.   +4 more
europepmc   +1 more source

Rethinking Perioperative Corticosteroids in Esophageal Cancer Surgery: Evidence From an Integrative Meta‐Analysis

Annals of Gastroenterological Surgery, Volume 10, Issue 4, Page 995-1007, July 2026.
ABSTRACT Background Esophagectomy remains a highly invasive procedure associated with substantial postoperative morbidity. Pulmonary complications, anastomotic leakage, and in‐hospital mortality are of particular concern. Perioperative corticosteroids are often administered to attenuate excessive inflammatory responses; however, the clinical impact in ...
Tomohiko Yasuda, Akihisa Matsuda, Nobutoshi Hagiwara, Yoshiharu Nakamura, Hiroshi Yoshida   +4 more
wiley   +1 more source

Pivotal studies of pharmacotherapies approved by the US FDA for cancer treatment: a meta-analysis. [PDF]

Oncologist
Chow R, Im JHB, Zimmermann C, Richards GC, Heneghan C.   +4 more
europepmc   +1 more source

Phenylbenzothiazole Bis(Cyclometalated) Pt(IV) Complexes With Phenanthroline‐Based Ligands as ROS, NADH and Microtubule Destabilizing Agents

Applied Organometallic Chemistry, Volume 40, Issue 7, July 2026.
This study presents the optical and biological properties of the neutral and cationic phenylbenzothiazole cyclometalated Pt(IV) [Pt(pbt)2Cl2] (1) and [Pt(pbt)2(N^N)](ClO4)2 (N^N = phen 2, pyraphen 3, NH2‐phen 4) complexes. Complexes 1 and 4 demonstrated 1O2 generation and catalytic NADH photooxidation under blue light irradiation. The highest cytotoxic
Andrea Corral‐Zorzano, David Gómez de Segura, Icíar P. López, José G. Pichel, Elena Lalinde, M. Teresa Moreno   +5 more
wiley   +1 more source

Beyond the Very Important Pharmacogenes (VIPs): Uncovering Shadow Pharmacogenes in the Human Drug Response Network. [PDF]

ACS Omega
de Melo NC, Accioli GS, Sánchez-Luquez K, Gomes MFF, Felicio AC, de Carvalho LM.   +5 more
europepmc   +1 more source

Chemo‐Immunotherapy, a Combination Approach for the Treatment of HER2‐Positive Breast Cancer in a Mouse Model

Cancer Medicine, Volume 15, Issue 7, July 2026.
Experimental workflow of HER2/Neu‐targeted dendritic cell‐based chemo‐immunotherapy in a 4T1‐HER2 breast cancer xenograft model. ABSTRACT The discovery of tumor‐associated antigens has been a significant milestone for cancer therapy as the current conventional therapies (radiotherapy, chemotherapy) were found to be insufficient in terms of cancer ...
Cenk Serhan Özverel, Kubilay Doğan Kılıç, Yiğit Uyanikgil, İsmail Karaboz, Ayse Nalbantsoy   +4 more
wiley   +1 more source

Time-Varying Hormonal Treatment and Metastasis-Free Survival Among ER+ Breast Cancer Patients: A Natural History Modelling Approach. [PDF]

Stat Med
Orsini L, Gasparini A, Czene K, Humphreys K.   +3 more
europepmc   +1 more source

Advancing Cancer Cachexia Drug Development: Leveraging Biomarkers and Functional Endpoints to Optimize Trial Design

Cancer Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background Cancer‐associated cachexia is a complex, multistage metabolic disorder that markedly contributes to morbidity and mortality in patients with advanced cancer, yet effective pharmacological interventions are lacking. Cachexia drug development has expanded significantly in recent years, with multiple repurposed agents and novel ...
Nada O. Othman, Hadir Habib, Doaa M. Almeldin, Kyrillus S. Shohdy   +3 more
wiley   +1 more source

Analysis of drug-induced pulmonary embolism risk based on the Food and Drug Administration Adverse Event Reporting System database. [PDF]

J Thorac Dis
Rui Y, Xiang B, Chen C, Chen Z, Lv J, Li T.   +5 more
europepmc   +1 more source