Results 141 to 150 of about 17,757 (259)

A Curcumin‐Derived HSP70 Inhibitor Disrupts Lysosomal Function to Suppress Triple‐Negative Breast Cancer Progression

Cell Proliferation, EarlyView.
Novel curcumin‐derived M4 binds HSP70's ATPase domain, disrupting HSP70‐mediated lysosomes‐autophagy pathway to inhibit TNBC growth and metastasis, and synergizes with paclitaxel for potent combination therapy. ABSTRACT Structural modification of curcumin yielded a novel series of 1,4‐pentadien‐3‐one oxime ether derivatives, among which compound M4 ...
Zijian Li, Wanxia Wang, Yuxin Zhou, Tao Zeng, Jian Liu, Yingjie Qing, Xuan Han   +6 more
wiley   +1 more source

Considerations for Menstrual Suppression in Patients With Hematologic Malignancies. [PDF]

Pharmacotherapy
Veeravalli S, Schepers A, Benitez LL, Fraga MS.   +3 more
europepmc   +1 more source

Oxygen‐independent expression of HIF‐1α during the cell cycle in hepatocellular carcinoma cells controls essential metabolic pathways under normoxia

The FEBS Journal, EarlyView.
In Huh7 cells, HIF‐1α is essential as it maintains the expression of proteins involved in glycolysis and steroid/cholesterol biosynthesis both under normoxia and hypoxia. On the other hand, in HeLa cells, these pathways are induced by HIF‐1α only under hypoxia.
Ioanna‐Maria Gkotinakou, Christina Arseni, Kreon Koukoulas, Martina Samiotaki, George Panayotou, George Simos, Ilias Mylonis   +6 more
wiley   +1 more source

Cross-national pharmacovigilance of drug-induced intestinal obstruction: disproportionality signals in FAERS and external validation in JADER. [PDF]

Front Pharmacol
Liu Y, Wu S.
europepmc   +1 more source

Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma

The FEBS Journal, EarlyView.
Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris, Paraskevi Ioannou, Nikolaos A. Afratis   +2 more
wiley   +1 more source

Stratification system for pharmaceutical care in cancer patients: Chinese expert consensus. [PDF]

Front Pharmacol
Chen Y, Ma X, Lin M, Hu Z, Zhou J, Qiu Y, Liu Z, Du S, Shi L, Han L, Chen Y, Qi T, Zhang Y, Li G, Xiao H.   +14 more
europepmc   +1 more source

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

Beyond the Very Important Pharmacogenes (VIPs): Uncovering Shadow Pharmacogenes in the Human Drug Response Network. [PDF]

ACS Omega
de Melo NC, Accioli GS, Sánchez-Luquez K, Gomes MFF, Felicio AC, de Carvalho LM.   +5 more
europepmc   +1 more source

Guidance on calculating doses of antineoplastic agents for transgender and gender-expansive patients taking gender-affirming hormone therapy

JAPhA Pharmacotherapy
Andréa C. LeVoir, Erica C. Stumpf, Wiktoria Bogdanska, Maly Fenelus, Ilya G. Glezerman, Lubaina Presswala, Boglarka Gyurkocza, Koshy Alexander, Kelly Haviland   +8 more
openaire   +1 more source

Extensive arterial and venous thrombo-embolism with chemotherapy for testicular cancer: a case report [PDF]

, 2009
Ramesh Batra, Jonathan N Davies, Duncan Wheatley, A Gerl, NI Weijl, A Azak, C Doehn, N Shahab, C Doll, A Goldhirsch, NJ Vogelzang, JT Licciardello, DC Doll, AJ Santos, J Pretnar-Oblak, BJ Roth, LH Einhorn, I Shintaku   +17 more
core   +1 more source