Results 31 to 40 of about 17,757 (259)

Eventos adversos causados por medicamentos en un hospital centinela del Estado de Goiás, Brasil [PDF]

, 2011
This was a retrospective, descriptive and documental study with the aim of identifying adverse drug events which occurred in the medication administration process and to classify these medication errors.
CASSIANI, Silvia Helena De Bortoli, MIASSO, Adriana Inocenti, REIS, Adriano Max Moreira, SANTOS, Jânia Oliveira, SILVA, Ana Elisa Bauer de Camargo   +4 more
core   +4 more sources

European Union pharmacovigilance capabilities : potential for the new legislation [PDF]

, 2015
European Directives and Regulations introduced between late 2010 and 2012 have substantially overhauled pharmacovigilance processes across the European Union (EU).
Aislaitner, George, Borg, John Joseph, Kouvelas, Dimitrios, Lungu, Calin, Pirozynski, Michal, Serracino-Inglott, Anthony, Tanti, Amy   +6 more
core   +1 more source

Adherence to adjuvant therapy in post-menopausal breast cancer patients: A review [PDF]

, 2011
This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2012 John Wiley & Sons, IncThis review aimed to address the concept of adherence to adjuvant therapy in post-menopausal women.
Banning, M
core   +1 more source

Access to medicines in Brazil based on monetary and non-monetary acquisition data obtained from the 2008/2009 Household Budget Survey [PDF]

, 2016
Objective: to investigate the access to medicines by Brazilian families by monetary and non-monetary acquisition data. Methods: this is a cross-sectional study based on data obtained from the 2008/2009 Brazilian Household Budget Survey.
Caldas, Eloisa Dutra, Goes, Fernanda Caroline Silva, Homem de Mello, Mauricio   +2 more
core   +3 more sources

Novel actions of next-generation taxanes benefit advanced stages of prostate cancer. [PDF]

, 2015
PURPOSE: To improve the outcomes of patients with castration-resistant prostate cancer (CRPC), there is an urgent need for more effective therapies and approaches that individualize specific treatments for patients with CRPC.
Berman-Booty, Lisa D., Ciment, Stephen J, de Leeuw, Renée, Den, Robert, Dicker, Adam P., Gomella, Leonard G., Kelly, William, Knudsen, Karen E., Lallas, Costas D., Schiewer, Matthew J., Trabulsi, Edouard J.   +10 more
core   +2 more sources

Chemotherapy and skin reactions. [PDF]

, 2012
BACKGROUND:New chemotherapic agents and new protocols in oncology have led to an increasing survival rate in patients affected by tumors. However, this increased use has been accompanied by a growth in the incidence of cutaneous side effects and a ...
Bianca D, Cameli N, FABBROCINI, GABRIELLA, MARIANO, MARIA, MONFRECOLA, GIUSEPPE, PANARIELLO, LUIGIA, Romano MC   +6 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source