Role of the mTOR pathway in normal and tumoral adrenal cells [PDF]
, 2010 The mammalian target of rapamycin (mTOR) is a kinase of the phosphoinositide 3-kinase (PI3Ks)/protein kinase B (PKB or AKT) signaling pathway, which is one of the most important intracellular mediators of the activity of growth factors receptors ...
Hofland, L.J. (Leo) +3 more
core +1 more source
Chlormadinone acetate is effective for hot flush during androgen deprivation therapy
Prostate International, 2013 To investigate the clinical efficacy of low-dose chlormadinone acetate (CMA) in prostate cancer patients who suffer from hot flushes that is a major side effect of androgen deprivation therapy.
Hidekazu Koike +5 more
doaj +1 more source
Trastuzumab (Herceptin (R)): Monoclonal antibody in the treatment of HER2/neu-overexpressing breast cancer in the metastatic and (neo)adjuvant situation [PDF]
, 2006 Trastuzumab (Herceptin (R)) is a humanized monoclonal antibody that specifically targets HER2/neu (human epidermal growth factor receptor-2) breast cancer cells, which are overexpressed in about 25-30% of breast carcinomas.
Bauerfeind, Ingo +7 more
core +2 more sources
First-line therapy in HER2 positive metastatic breast cancer. Is the mosaic fully completed or are we missing additional pieces? [PDF]
, 2016 The discovery of human epidermal growth factor receptor 2 (HER2) and its role in the biology of breast cancer and the subsequent development of HER2-targeted therapies, have dramatically improved clinical outcomes for women with early-stage and advanced ...
Cognetti F. +3 more
core +2 more sources
Indication-wide drug pricing: Insights from the pharma market
Journal of Pharmaceutical Policy and Practice, 2022 Background Pharmaceutical spending has been increasing rapidly for years and is higher than ever before. To control the rising costs, countries are implementing regulatory frameworks such as (internal) reference pricing, price cuts or generics ...
Florian Siegmeier, Melanie Büssgen
doaj +1 more source
Medication use by early-stage breast cancer survivors: a 1-year longitudinal study. [PDF]
, 2016 PurposeThe aim of this study is to characterize the patterns of medication use by early-stage breast cancer (ESBC) survivors from diagnosis to 1 year post-chemotherapy.MethodsA single-center longitudinal study was conducted with ESBC patients diagnosed ...
Chan, Alexandre +4 more
core +1 more source
Health care‐related time costs in patients with metastatic breast cancer
Cancer Medicine, 2020 Background Burdens related to time spent receiving cancer care may be substantial for patients with incurable, life‐limiting cancers such as metastatic breast cancer (MBC).
Gabrielle B. Rocque +8 more
doaj +1 more source
Risks of hospitalization and drug consumption in children and young adults with diagnosed celiac disease and the role of maternal education: A population-based matched birth cohort study [PDF]
, 2016 Background: Celiac disease (CD) may affect healthcare use in children and young adults. Socio-economic factors may act as a confounder or effect modifier.
Canova, Cristina +6 more
core +6 more sources
EO771, is it a well‐characterized cell line for mouse mammary cancer model? Limit and uncertainty
Cancer Medicine, 2020 Among mouse mammary tumor models, syngeneic cell lines present an advantage for the study of immune response. However, few of these models are well characterized. The tumor line EO771 is derived from spontaneous breast cancer of C57BL/6 mice. These cells
Augustin Le Naour +2 more
doaj +1 more source
Predicting Anatomical Therapeutic Chemical (ATC) classification of drugs by integrating chemical-chemical interactions and similarities. [PDF]
PLoS ONE, 2012 The Anatomical Therapeutic Chemical (ATC) classification system, recommended by the World Health Organization, categories drugs into different classes according to their therapeutic and chemical characteristics.
Lei Chen +4 more
doaj +1 more source