Results 101 to 110 of about 175,055 (304)
FEBS Open Bio, EarlyView.The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani +7 more
wiley +1 more source
American Journal of Experimental and Clinical Research, 2019 It is well described that handling antineoplastic medications without proper personal and environmental protections leads to malignancy, reproductive toxicity, and organ damage.
Veronica Bonderski +2 more
doaj
Cerebrospinal Fluid (CSF) Directed Antineoplastic Agents: A Review of Current Knowledge [PDF]
, 2015 Damian A. Laber
openalex +1 more source
Antineoplastic Hormonal/Endocrine Agent [PDF]
, 2020 National Cancer Institute
openalex +1 more source
α-N-heterocyclic thiosemicarbazone derivatives as potential antitumor agents: A structure-activity relationships approach [PDF]
, 2009 α-N-Heterocyclic thiosemicarbazones, (N)-TSCs, are potent inhibitors of ribonucleotide reductase (RR). This enzyme plays a critical role in DNA synthesis and repair, and is a well-recognized target for cancer chemotherapeutic agents.
Matesanz, Ana I., Souza, Pilar
core +2 more sources
FEBS Open Bio, EarlyView.We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley +1 more source
Clinical Toxicities of Histone Deacetylase Inhibitors
Pharmaceuticals, 2010 The HDAC inhibitors are a new family of antineoplastic agents. Since the entry of these agents into our therapeutic armamentarium, there has been increasing interest in their use.
Richard L. Piekarz +4 more
doaj +1 more source
Mechanisms of cross resistance between cisplatin and bleomycin in saccharomyces cerevisiae [PDF]
, 2019 Tumor cells can simultaneously acquire resistance against a diverse group of drugs. This phenomenon is called pleotropic resistance or multidrug resistance.
Burgos-Molina, Antonio Manuel +2 more
core
Arthritis Care &Research, EarlyView.Objective Systemic sclerosis (SSc) is a rare autoimmune disease characterized by tissue fibrosis, vasculopathy, and immune dysregulation. Our objectives were to quantify the overall and site‐specific cancer risks in patients with SSc compared to the general population, examine temporal trends in cancer incidence following SSc diagnosis, and explore ...
Jihyun Na +4 more
wiley +1 more source