Results 121 to 130 of about 3,367,527 (366)
α-N-heterocyclic thiosemicarbazone derivatives as potential antitumor agents: A structure-activity relationships approach [PDF]
, 2009 α-N-Heterocyclic thiosemicarbazones, (N)-TSCs, are potent inhibitors of ribonucleotide reductase (RR). This enzyme plays a critical role in DNA synthesis and repair, and is a well-recognized target for cancer chemotherapeutic agents.
Matesanz, Ana I., Souza, Pilar
core +2 more sources
Antineoplastic agents. XIX. N-Bis(2-haloethyl)glycine amides [PDF]
, 1967 George R. Pettit +2 more
openalex +1 more source
FEBS Open Bio, EarlyView.In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr +5 more
wiley +1 more source
Antineoplastic Drug-Induced Cardiotoxicity: A Redox Perspective
Frontiers in Physiology, 2018 Antineoplastic drugs can be associated with several side effects, including cardiovascular toxicity (CTX). Biochemical studies have identified multiple mechanisms of CTX.
Gilda Varricchi +19 more
doaj +1 more source
Procjena genotoksičnosti bleomicina i mitomicina C metodom kometnog testa [PDF]
, 2004 Although chemotherapy targets cancer tissue, it also damages the DNA of non-cancer cells. The aim of this study was to evaluate the in vitro genotoxic potential of therapeutic concentrations of bleomycin and mitomycin C, added alone or in combination to ...
Mirta Milić, Nevenka Kopjar
core +1 more source
Nifurtimox Is Effective Against Neural Tumor Cells and Is Synergistic with Buthionine Sulfoximine. [PDF]
, 2016 Children with aggressive neural tumors have poor survival rates and novel therapies are needed. Previous studies have identified nifurtimox and buthionine sulfoximine (BSO) as effective agents in children with neuroblastoma and medulloblastoma.
Du, Michael +4 more
core +1 more source
Antineoplastic agents 32. The pseudoguaianolide helenalin [PDF]
, 1973 George R. Pettit, Gordon M. Cragg
openalex +1 more source
FEBS Open Bio, EarlyView.Statins, identified via the Comparative Toxicogenomics Database, promote monocytic differentiation and apoptosis in non‐APL AML cells by upregulating DPYSL2A through a KLF4‐dependent pathway. Mevalonate supplementation reversed these effects, indicating involvement of the mevalonate pathway.
Mina Noura +7 more
wiley +1 more source
Safe Handling of Antineoplastic Drugs in Oncology Nursing
Sağlık ve Hemşirelik Yönetimi Dergisi, 2014 Today the oncology nursing importance has been increased because of that cancer is one of the most important health problem in Turkey, as it is in the other countries throughout the world. By the way antineoplalastic drugs, which not only effect patients
Rujnan Tuna
doaj +1 more source