Results 121 to 130 of about 3,462,732 (382)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A United States pharmacopeia chapter 800-centered process improvement proposal for compounding antineoplastic medications in an academic medical center pharmacy

American Journal of Experimental and Clinical Research, 2019
It is well described that handling antineoplastic medications without proper personal and environmental protections leads to malignancy, reproductive toxicity, and organ damage.
Veronica Bonderski, Mary Clay, Raoof Abdellatif   +2 more
doaj  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Clinical Toxicities of Histone Deacetylase Inhibitors

Pharmaceuticals, 2010
The HDAC inhibitors are a new family of antineoplastic agents. Since the entry of these agents into our therapeutic armamentarium, there has been increasing interest in their use.
Richard L. Piekarz, John J. Wright, Susan E. Bates, Srividya Subramanian, Igor Espinoza-Delgado   +4 more
doaj   +1 more source

26,26,26,27,27,27-Hexadeuterated-1,25-Dihydroxyvitamin D3 (1,25D-d6) As Adjuvant of Chemotherapy in Breast Cancer Cell Lines [PDF]

, 2013
It has been demonstrated that 1,25-dihydroxyvitamin D3 (1,25D) and some of its analogues have antitumor activity. 1,25D labeled with deuterium (26,26,26,27,27,27-hexadeuterated 1a,25-dihydroxyvitamin D3, or 1,25D-d6) is commonly used as internal ...
Abdul-Hadi, Soraya, Bermúdez, María José, Maestro, Miguel, Martínez Ordóñez, Anxo, Mouriño, Antonio, Pérez-Fernández, Román, Sendón Lago, Juan José, Seoane, Samuel   +7 more
core   +4 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Prescribing pattern and prescription-writing quality of antineoplastic agents in the capital city of a middle-income developing country

Journal of Research in Pharmacy Practice, 2018
Objective: Cancer is a global health concern with growing incidence worldwide. Chemotherapy is the main treatment modality in many malignancies. This study aimed at evaluation of antineoplastic prescribing pattern and prescription-writing quality in the ...
Maryam Taghizadeh-Ghehi, Asiyeh Amouei, Ava Mansouri, Aarefeh Jafarzadeh Kohneloo, Molouk Hadjibabaie   +4 more
doaj   +1 more source

Influence of the treatment with the antineoplastic agents 5-fluorouracil and cisplatin on the severity of experimental periodontitis in rats

, 2021
Vivian Cristina Noronha Novaes, Edílson Ervolino, Giovani Lopes Fernandes, Clara Possarle Cunha, Letícia Helena Theodoro, Valdir Gouveia Garcia, Juliano Milanezi de Almeida   +6 more
openalex   +2 more sources

Acupressure to Reduce Treatment-Related Symptoms for Children With Cancer and Recipients of Hematopoietic Stem Cell Transplant: Protocol for a Randomized Controlled Trial. [PDF]

, 2019
BackgroundWe describe the study design and protocol of a pragmatic randomized controlled trial (RCT) Acupressure for Children in Treatment for a Childhood Cancer (ACT-CC).ObjectiveTo describe the feasibility and effectiveness of an acupressure ...
Adcock, Robyn, Banerjee, Anu, Dvorak, Christopher C, Golden, Carla, Hartogensis, Wendy, Hecht, Frederick M, Hu, Hiroe, Lown, E Anne, Mangurian, Christina, Melton, Alexis, Morgan, Michael, Shear, Deborah, Vittinghoff, Eric   +12 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source