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Thalidomide: An antineoplastic agent
Current Oncology Reports, 2002It has been more than three decades since the withdrawal of thalidomide from the marketplace. Thalidomide is attracting growing interest because of its reported immunomodulatory and anti-inflammatory properties. Current evidence indicates that thalidomide reduces the activity of the inflammatory cytokine tumor necrosis factor-alpha by accelerating the ...
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Hypersensitivity to Antineoplastic Agents
Current Pharmaceutical Design, 2008The need to offer first line therapy for primary and recurrent cancers has spurred the clinical development of rapid desensitizations for chemotherapy and monoclonal antibodies. Rapid desensitizations allow patients to be treated with medications to which they have presented with hypersensitivity reactions (HSRs), including anaphylaxis.
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Antineoplastic Agents, 88. Pimelea prostrata
Journal of Natural Products, 1983The aerial portion of Pimelea prostrata (Thymelaeaceae) collected in New Zealand was evaluated as a source of substances that inhibit growth of the murine P-388 lymphocytic leukemia (PS). Simplexin (1) and Pimelea factor P2 (2) were found to strongly inhibit growth (ED50 5 X 10(-3) and 8 X 10(-4) micrograms/ml, respectively) of the PS in vitro cell ...
G R, Pettit +4 more
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1989
New antineoplastic agents are being developed predominantly in industrial laboratories and only to a limited extent in university and other research institutes. The results of so-called screening assays, as conducted especially by the National Cancer Institute, have been disappointing in particular since the testing of many hundreds or thousands of ...
D. Schmähl +3 more
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New antineoplastic agents are being developed predominantly in industrial laboratories and only to a limited extent in university and other research institutes. The results of so-called screening assays, as conducted especially by the National Cancer Institute, have been disappointing in particular since the testing of many hundreds or thousands of ...
D. Schmähl +3 more
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Innovative antineoplastic agents.
Journal of intravenous nursing : the official publication of the Intravenous Nurses Society, 2002Cancer treatment options are changing as a result of extensive research efforts. New drugs and drug combinations proceed through specific phases of clinical research leading to possible Food and Drug Administration review and approval. Phase I, II, III, and IV clinical trials have detailed enrollment criteria and treatment plans designed to determine ...
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