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Advanced Science, EarlyView.ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei +11 more
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Possible Antineoplastic Agents II
Journal of Pharmaceutical Sciences, 1975A few thalidomide and glutarimide derivatives were synthesized. Several compounds possessed significant antineoplastic activity against Ehrlich ascites carcinoma in Swiss albino mice.
A U, De, D, Pal
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Critical Care Nursing Quarterly, 1996
Advances in the field of oncology have led to the development of many antineoplastic agents for the treatment of cancer. Combination with other agents and modalities, along with dose intensification, has resulted in more toxicities, often requiring careful management and monitoring in the critical care setting.
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Advances in the field of oncology have led to the development of many antineoplastic agents for the treatment of cancer. Combination with other agents and modalities, along with dose intensification, has resulted in more toxicities, often requiring careful management and monitoring in the critical care setting.
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Antineoplastic Agents from Plants
Annual Review of Pharmacology and Toxicology, 1977Since at least 1500 Be plants and plant extracts have been recognized as having anticancer activities (1). Surveys by Hartwell (2, 3) listed at least 3000 species so used. However the rational, organized study of plants as sources of potential an tineoplastic agents probably commenced with the pioneering studies of Hartwell et al (4-8) during the ...
M E, Wall, M C, Wani
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Butterfly wing antineoplastic agents
Experientia, 1972Eine Voruntersuchung der Insektengruppe Lepidoptera auf anti-tumor-aktive Stoffe fuhrte zu einer detaillierten chemischen Prufung der aus Asien stammenden SchmetterlingeCatopsilia crocale Cramer (Pieridae) undPieris rapae cruavora. Ein bedeutender Teil der Anti-Tumor-Aktivitat scheint ihren Ursprung in der chemischen Substanz Isoxanthopterin zu ...
G R, Pettit +8 more
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Antineoplastic Agents. 605. Isoquinstatins
Journal of Natural Products, 2017In order to further explore quinoline-type structural modification of the powerful anticancer drug dolastatin 10, an Indian Ocean sea hare constituent and parent molecule of the very successful antibody drug conjugate (ADC) Adcetris, our recent quinstatin study has been extended by replacing the quinoline ring with an isoquinoline.
George R. Pettit +2 more
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Neurotoxicity of antineoplastic agents
Critical Reviews in Oncology/Hematology, 1993to review the neurotoxicity associated with antineoplastic agents.four hundred articles, abstracts and book chapters were selected for review. One hundred and ninety (articles, book chapters and abstracts) were identified as representative of the important aspects of neurotoxicity to be presented in this review.in general the dose, schedule and route ...
M, Hussain, A J, Wozniak, M B, Edelstein
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Tetrahedron, 1985
Abstract An intensive investigation of the marine animal AAmathia convoluta (Bryozoa phylum) for antineoplastic constituents has led to the isolation and structural determination of bryostatin 8 (2). A total of 100 kg of Amathia convoluta was required to obtain some 4.2 mg of bryostatin 8.
G.R Pettit +6 more
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Abstract An intensive investigation of the marine animal AAmathia convoluta (Bryozoa phylum) for antineoplastic constituents has led to the isolation and structural determination of bryostatin 8 (2). A total of 100 kg of Amathia convoluta was required to obtain some 4.2 mg of bryostatin 8.
G.R Pettit +6 more
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Expert Opinion on Therapeutic Patents, 1998
This review will focus on the most recent patent-disclosed advances in identifying new potent drugs for cancer chemotherapy since the subject was last discussed in this journal in 1997, with the exception of fields that have been subsequently covered by other more focused reviews in the same journal.In particular we will summarise developments in the ...
MENTA E, PALUMBO, MANLIO
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This review will focus on the most recent patent-disclosed advances in identifying new potent drugs for cancer chemotherapy since the subject was last discussed in this journal in 1997, with the exception of fields that have been subsequently covered by other more focused reviews in the same journal.In particular we will summarise developments in the ...
MENTA E, PALUMBO, MANLIO
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Expert Opinion on Therapeutic Patents, 1997
Cancer chemotherapy represents a major expanding field of academic and industrial research. Many directions have been taken to identify new active compounds as more and more knowledge is gained on the mechanisms of pharmacological action through molecular biology techniques and structural studies at the molecular level.
MENTA E, PALUMBO, MANLIO
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Cancer chemotherapy represents a major expanding field of academic and industrial research. Many directions have been taken to identify new active compounds as more and more knowledge is gained on the mechanisms of pharmacological action through molecular biology techniques and structural studies at the molecular level.
MENTA E, PALUMBO, MANLIO
openaire +2 more sources