Results 241 to 250 of about 152,699 (284)
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Pharmacology of antineoplastic agents in pregnancy
Critical Reviews in Oncology/Hematology, 1994The use of antineoplastic agents in pregnant women poses obvious risks to both the patient and the developing fetus, particularly during organogenesis. While the use of antineoplastics during pregnancy is often unavoidable, the physician may limit the risks by having a clear knowledge of the pharmacology and teratogenic potential of individual agents ...
V J, Wiebe, P E, Sipila
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Vascular Toxicity of Antineoplastic Agents
Seminars in Oncology, 2006Among the various deleterious effects of cancer chemotherapy, vascular toxicity is the least well recognized. This lack of recognition may be because the vasculotoxic phenomena are not unique to antineoplastic agents, can occur in patients without exposure to these agents, and the fact cancer itself may produce a hypercoagulable state.
Nasir, Shahab +2 more
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Butterfly wing antineoplastic agents
Experientia, 1972Eine Voruntersuchung der Insektengruppe Lepidoptera auf anti-tumor-aktive Stoffe fuhrte zu einer detaillierten chemischen Prufung der aus Asien stammenden SchmetterlingeCatopsilia crocale Cramer (Pieridae) undPieris rapae cruavora. Ein bedeutender Teil der Anti-Tumor-Aktivitat scheint ihren Ursprung in der chemischen Substanz Isoxanthopterin zu ...
G R, Pettit +8 more
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Antineoplastic Agents from Plants
Annual Review of Pharmacology and Toxicology, 1977Since at least 1500 Be plants and plant extracts have been recognized as having anticancer activities (1). Surveys by Hartwell (2, 3) listed at least 3000 species so used. However the rational, organized study of plants as sources of potential an tineoplastic agents probably commenced with the pioneering studies of Hartwell et al (4-8) during the ...
M E, Wall, M C, Wani
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Offsetting toxicity of antineoplastic agents
Journal of Surgical Oncology, 1975AbstractPCO, a yeast extract, offsets at least in part the mitotic inhibitory effect of methotrexate and fluorouracil on bone marrow cells in vitro but increases the antimitotic activity of the drugs on ascites Krebs‐2 carcinoma under similar conditions.
E S, Cook +4 more
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Antineoplastic Agents. 606. The Betulastatins
Journal of Natural Products, 2018The medicinal potential of the plant pentacyclic triterpene betulin has generated long-term interest focused on various SAR research avenues. The present approach was based on producing further analogues (chimeras) arising from a studied modification of betulin bonded to the Dov-Val-Dil-Dap unit of the powerful anticancer drug dolastatin 10, which ...
George R. Pettit +2 more
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Musculoskeletal Effects of Antineoplastic Agents
Journal of the American Academy of Orthopaedic Surgeons, 2019Cancer remains a common disease with approximately 40% of Americans diagnosed with cancer in their lifetime. Medical advances in the field of oncology have led to an increased life expectancy and a decreased mortality rate. Antineoplastic agents such as taxanes and targeted therapies are indicated in the treatment of many cancers, and their use can be ...
Karen, Sutton +3 more
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Antineoplastic Agents. 605. Isoquinstatins
Journal of Natural Products, 2017In order to further explore quinoline-type structural modification of the powerful anticancer drug dolastatin 10, an Indian Ocean sea hare constituent and parent molecule of the very successful antibody drug conjugate (ADC) Adcetris, our recent quinstatin study has been extended by replacing the quinoline ring with an isoquinoline.
George R. Pettit +2 more
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CHEMOSTERILANT ACTIVITY OF ANTINEOPLASTIC AGENTS
Transactions of the New York Academy of Sciences, 1974AbstractThirty‐five antineoplastic agents were administered to adult house flies, Musca domestica L., by feeding or injection, and effects of the treatment on the flies' reproductive capacity were determined. For both sexes of the insect the most effective sterilants were alkylating agents; none of the hormonal drugs were active, but one antimetabolite
S C, Chang, A B, Borkovec, B H, Braum
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Antineoplastic agents and their oral manifestations
Oral Surgery, Oral Medicine, Oral Pathology, 1977The use of antineoplastic agents is rapidly increasing. A general classification of these drugs and their mechanisms of action is presented. Many of the drugs have an adverse effect on oral tissue, and the practicing dentist today must be well acquainted with these effects.
W K, Bottomley, E, Perlin, G R, Ross
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