Results 301 to 310 of about 3,462,732 (382)
Advanced Science, EarlyView.The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang +15 more
wiley +1 more source
Advanced Science, EarlyView.This study shows anti‐CEACAM5 CAR T‐cells are ineffective against colorectal cancer (CRC) because of CEACAM5 sequestration at intercellular junctions and the thick tumour cell glycocalyx. Enzymatic treatments of CRC cell monolayer/tissue section with trypsin or hyaluronidase restore CEACAM5 availability, enhance CAR T‐cell activation, increase ...
Debasis Banik +13 more
wiley +1 more source
Alkyltriphenylphosphonium Binding to Cardiolipin Triggers Oncosis in Cancer Cells
Advanced Science, EarlyView.Alkyltriphenylphosphonium, exemplified by TPP+‐C14, preferentially accumulates in mitochondria and selectively binds to cardiolipin, a key phospholipid of the inner mitochondrial membrane, causing loss of mitochondrial membrane potential, severe cellular ATP depletion, and calcium imbalance.
Jin Li +8 more
wiley +1 more source
Advanced Science, EarlyView.Histone 3 lysine18 lactylation (H3K18la) drives heterogeneous nuclear ribonucleoprotein C (HNRNPC) overexpression, activating autophagy to mediate gemcitabine resistance by stabilizing TNF receptor‐associated factor 6 (TRAF6) mRNA. Concurrently, HNRNPC stabilizes aldehyde dehydrogenase 1 family member A3 (ALDH1A3) mRNA, which enhances glycolysis and ...
Xi‐Tai Huang +9 more
wiley +1 more source
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Occupational Hazards in the Health Professions, 2020
John Widström, Christer Edling
openaire +2 more sources
John Widström, Christer Edling
openaire +2 more sources
Anti-Cancer Agents in Medicinal Chemistry, 2020
BACKGROUND In these days, most of the drugs used in clinical applications show their pharmacological influences by inhibiting or activating enzymes. Therefore, enzyme inhibitors have an essential place in the drug design for many diseases.
Yeliz Demir +2 more
semanticscholar +1 more source
BACKGROUND In these days, most of the drugs used in clinical applications show their pharmacological influences by inhibiting or activating enzymes. Therefore, enzyme inhibitors have an essential place in the drug design for many diseases.
Yeliz Demir +2 more
semanticscholar +1 more source
Possible Antineoplastic Agents II
Journal of Pharmaceutical Sciences, 1975A few thalidomide and glutarimide derivatives were synthesized. Several compounds possessed significant antineoplastic activity against Ehrlich ascites carcinoma in Swiss albino mice.
A U, De, D, Pal
openaire +3 more sources
Current Medicinal Chemistry, 2019
BACKGROUND Computer-Aided Drug Design has strongly accelerated the development of novel antineoplastic agents by helping in the hit identification, optimization, and evaluation.
J. Vučićević +2 more
semanticscholar +1 more source
BACKGROUND Computer-Aided Drug Design has strongly accelerated the development of novel antineoplastic agents by helping in the hit identification, optimization, and evaluation.
J. Vučićević +2 more
semanticscholar +1 more source