Results 311 to 320 of about 210,920 (352)

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

open access: yesAdvanced Science, EarlyView.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang   +10 more
wiley   +1 more source

Icaritin Represses Autophagy to Promote Colorectal Cancer Cell Apoptosis and Sensitized Low‐Temperature Photothermal Therapy via Targeting HSP90‐TXNDC9 Interactions

open access: yesAdvanced Science, EarlyView.
Icaritin demonstrates broad antitumor effects by inhibiting colorectal cancer (CRC) cell proliferation, migration, invasion, and causing cell cycle arrest. It induces apoptosis by repressing autophagic flux through disrupting HSP90‐TXNDC9 interactions.
Dan He   +6 more
wiley   +1 more source

Neurotoxicity of antineoplastic agents

Critical Reviews in Oncology/Hematology, 1993
to review the neurotoxicity associated with antineoplastic agents.four hundred articles, abstracts and book chapters were selected for review. One hundred and ninety (articles, book chapters and abstracts) were identified as representative of the important aspects of neurotoxicity to be presented in this review.in general the dose, schedule and route ...
M.A.rk B. Edelstein   +2 more
openaire   +3 more sources

Antineoplastic agents 1998

Expert Opinion on Therapeutic Patents, 1998
This review will focus on the most recent patent-disclosed advances in identifying new potent drugs for cancer chemotherapy since the subject was last discussed in this journal in 1997, with the exception of fields that have been subsequently covered by other more focused reviews in the same journal.In particular we will summarise developments in the ...
MENTA E, PALUMBO, MANLIO
openaire   +3 more sources

Novel antineoplastic agents

Expert Opinion on Therapeutic Patents, 1997
Cancer chemotherapy represents a major expanding field of academic and industrial research. Many directions have been taken to identify new active compounds as more and more knowledge is gained on the mechanisms of pharmacological action through molecular biology techniques and structural studies at the molecular level.
MENTA E, PALUMBO, MANLIO
openaire   +3 more sources

Antineoplastic Agents

2016
Cancer is a term used for group of more than 120 distinct diseases that are characterized by the uncontrolled growth of abnormal cells in the body, which are able to invade other tissues, eventually causing death. There are several strategies to treat cancer, including surgery, radiation therapy, immunologic treatment, and chemical-based approaches ...
Ruben Vardanyan, Victor J. Hruby
openaire   +3 more sources

Possible Antineoplastic Agents II

Journal of Pharmaceutical Sciences, 1975
A few thalidomide and glutarimide derivatives were synthesized. Several compounds possessed significant antineoplastic activity against Ehrlich ascites carcinoma in Swiss albino mice.
D. Pal, A.U. De
openaire   +4 more sources

Antineoplastic agents

Critical Care Nursing Quarterly, 1996
Advances in the field of oncology have led to the development of many antineoplastic agents for the treatment of cancer. Combination with other agents and modalities, along with dose intensification, has resulted in more toxicities, often requiring careful management and monitoring in the critical care setting.
openaire   +2 more sources

Interactions of antimicrobial agents and antineoplastic agents

Journal of Antimicrobial Chemotherapy, 1986
The in-vitro interactions of four antimicrobial agents (piperacillin, dibekacin, minocycline, norfloxacin) and four antineoplastic agents (mitomycin C, bleomycin, doxorubicin, 5-fluorouracil) were examined by the chequerboard dilution method using 108 clinical isolates of four species of Gram-negative bacilli.
Saikawa Isamu   +5 more
openaire   +3 more sources

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