Results 311 to 320 of about 3,376,621 (386)
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Thrombotic microangiopathies and antineoplastic agents
Néphrologie & Thérapeutique, 2017Thrombotic microangiopathy is a well-described complication of cancer treatment. Its incidence has increased these last decades, as a result of a better awareness of this complication in cancer patients in one hand, but also of a larger array of therapeutic compounds including anti-vascular endothelium growth factor (VEGF) drugs.
Steven Grangé, Paul Coppo
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Anti-Cancer Agents in Medicinal Chemistry, 2020
BACKGROUND In these days, most of the drugs used in clinical applications show their pharmacological influences by inhibiting or activating enzymes. Therefore, enzyme inhibitors have an essential place in the drug design for many diseases.
Yeliz Demir +2 more
semanticscholar +1 more source
BACKGROUND In these days, most of the drugs used in clinical applications show their pharmacological influences by inhibiting or activating enzymes. Therefore, enzyme inhibitors have an essential place in the drug design for many diseases.
Yeliz Demir +2 more
semanticscholar +1 more source
Neurotoxicity of antineoplastic agents
Critical Reviews in Oncology/Hematology, 1993to review the neurotoxicity associated with antineoplastic agents.four hundred articles, abstracts and book chapters were selected for review. One hundred and ninety (articles, book chapters and abstracts) were identified as representative of the important aspects of neurotoxicity to be presented in this review.in general the dose, schedule and route ...
M.A.rk B. Edelstein +2 more
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Expert Opinion on Therapeutic Patents, 1998
This review will focus on the most recent patent-disclosed advances in identifying new potent drugs for cancer chemotherapy since the subject was last discussed in this journal in 1997, with the exception of fields that have been subsequently covered by other more focused reviews in the same journal.In particular we will summarise developments in the ...
MENTA E, PALUMBO, MANLIO
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This review will focus on the most recent patent-disclosed advances in identifying new potent drugs for cancer chemotherapy since the subject was last discussed in this journal in 1997, with the exception of fields that have been subsequently covered by other more focused reviews in the same journal.In particular we will summarise developments in the ...
MENTA E, PALUMBO, MANLIO
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Current Medicinal Chemistry, 2019
BACKGROUND Computer-Aided Drug Design has strongly accelerated the development of novel antineoplastic agents by helping in the hit identification, optimization, and evaluation.
J. Vučićević +2 more
semanticscholar +1 more source
BACKGROUND Computer-Aided Drug Design has strongly accelerated the development of novel antineoplastic agents by helping in the hit identification, optimization, and evaluation.
J. Vučićević +2 more
semanticscholar +1 more source
Expert Opinion on Therapeutic Patents, 1997
Cancer chemotherapy represents a major expanding field of academic and industrial research. Many directions have been taken to identify new active compounds as more and more knowledge is gained on the mechanisms of pharmacological action through molecular biology techniques and structural studies at the molecular level.
MENTA E, PALUMBO, MANLIO
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Cancer chemotherapy represents a major expanding field of academic and industrial research. Many directions have been taken to identify new active compounds as more and more knowledge is gained on the mechanisms of pharmacological action through molecular biology techniques and structural studies at the molecular level.
MENTA E, PALUMBO, MANLIO
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Possible Antineoplastic Agents II
Journal of Pharmaceutical Sciences, 1975A few thalidomide and glutarimide derivatives were synthesized. Several compounds possessed significant antineoplastic activity against Ehrlich ascites carcinoma in Swiss albino mice.
D. Pal, A.U. De
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Interactions of antimicrobial agents and antineoplastic agents
Journal of Antimicrobial Chemotherapy, 1986The in-vitro interactions of four antimicrobial agents (piperacillin, dibekacin, minocycline, norfloxacin) and four antineoplastic agents (mitomycin C, bleomycin, doxorubicin, 5-fluorouracil) were examined by the chequerboard dilution method using 108 clinical isolates of four species of Gram-negative bacilli.
Saikawa Isamu +5 more
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Critical Care Nursing Quarterly, 1996
Advances in the field of oncology have led to the development of many antineoplastic agents for the treatment of cancer. Combination with other agents and modalities, along with dose intensification, has resulted in more toxicities, often requiring careful management and monitoring in the critical care setting.
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Advances in the field of oncology have led to the development of many antineoplastic agents for the treatment of cancer. Combination with other agents and modalities, along with dose intensification, has resulted in more toxicities, often requiring careful management and monitoring in the critical care setting.
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Tetrahedron, 1985
Abstract An intensive investigation of the marine animal AAmathia convoluta (Bryozoa phylum) for antineoplastic constituents has led to the isolation and structural determination of bryostatin 8 (2). A total of 100 kg of Amathia convoluta was required to obtain some 4.2 mg of bryostatin 8.
Dennis L. Doubek +6 more
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Abstract An intensive investigation of the marine animal AAmathia convoluta (Bryozoa phylum) for antineoplastic constituents has led to the isolation and structural determination of bryostatin 8 (2). A total of 100 kg of Amathia convoluta was required to obtain some 4.2 mg of bryostatin 8.
Dennis L. Doubek +6 more
openaire +2 more sources