Results 331 to 340 of about 210,920 (352)

Toxicities of the platinum antineoplastic agents

Expert Opinion on Drug Safety, 2003
The platinum agents (cisplatin, carboplatin and oxaliplatin) are among the most useful anticancer agents available to oncologists. The drugs have the potential to produce both mild and more serious side effects. However, in general, the platinum agents can be delivered with acceptable toxicity, even when used in combination chemotherapy regimens ...
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Antineoplastic agents and their oral manifestations

Oral Surgery, Oral Medicine, Oral Pathology, 1977
The use of antineoplastic agents is rapidly increasing. A general classification of these drugs and their mechanisms of action is presented. Many of the drugs have an adverse effect on oral tissue, and the practicing dentist today must be well acquainted with these effects.
William K. Bottomley, Elliott Perlin, G. R. Ross   +2 more
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Carcinogenicity of antineoplastic agents in man

Cancer Treatment Reviews, 1984
Review of the literature shows that: Anticancer drugs are in all probability mostly also carcinogenic. Alkylating agents such as melphalan, chlorambucil and cyclophosphamide seem to lead to the highest rate of second malignancies. Second malignancies after antitumour drugs are mostly acute leukaemias.
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Antineoplastic agents and thrombotic microangiopathy

Journal of Oncology Pharmacy Practice, 2016
Thrombotic microangiopathy is an uncommon but reported adverse effect of a variety of antineoplastic drugs, including chemotherapy agents such as mitomycin C and gemcitabine, and newer targeted agents such as the vascular endothelial growth factor inhibitors.
Jean Paul Atallah, Gwenalyn Garcia
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CHEMOSTERILANT ACTIVITY OF ANTINEOPLASTIC AGENTS

Transactions of the New York Academy of Sciences, 1974
AbstractThirty‐five antineoplastic agents were administered to adult house flies, Musca domestica L., by feeding or injection, and effects of the treatment on the flies' reproductive capacity were determined. For both sexes of the insect the most effective sterilants were alkylating agents; none of the hormonal drugs were active, but one antimetabolite
Alexej B. Bořkovec, S. C. Chang, B. H. Braun   +2 more
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Thrombotic microangiopathies and antineoplastic agents

Néphrologie & Thérapeutique, 2017
Thrombotic microangiopathy is a well-described complication of cancer treatment. Its incidence has increased these last decades, as a result of a better awareness of this complication in cancer patients in one hand, but also of a larger array of therapeutic compounds including anti-vascular endothelium growth factor (VEGF) drugs.
Steven Grangé, Paul Coppo
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Antineoplastic Agents. 606. The Betulastatins

Journal of Natural Products, 2018
The medicinal potential of the plant pentacyclic triterpene betulin has generated long-term interest focused on various SAR research avenues. The present approach was based on producing further analogues (chimeras) arising from a studied modification of betulin bonded to the Dov-Val-Dil-Dap unit of the powerful anticancer drug dolastatin 10, which ...
George R. Pettit, Noeleen Melody, Jean-Charles Chapuis   +2 more
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Offsetting toxicity of antineoplastic agents

Journal of Surgical Oncology, 1975
AbstractPCO, a yeast extract, offsets at least in part the mitotic inhibitory effect of methotrexate and fluorouracil on bone marrow cells in vitro but increases the antimitotic activity of the drugs on ascites Krebs‐2 carcinoma under similar conditions.
M. Agnes Bernadette Proudfoot, John C. Fardon, Elton S. Cook, M. Eymard Poydock, Leo G. Nutini   +4 more
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Chemical carcinogenicity and the antineoplastic agents

American Journal of Health-System Pharmacy, 1984
The subject of chemical carcinogenicity is reviewed with discussions of the involved environmental factors, proposed mechanisms of mutagenesis and carcinogenesis, dose-response considerations, secondary tumor development, and an emphasis on the potential carcinogenicity of antineoplastic agents. Although the causes of various cancers are complex, 70-90%
AE Wade, AT Taylor
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Ocular Toxicity of Antineoplastic Agents

Ophthalmology, 1983
The increased use of chemotherapeutic agents has resulted in longer patient survival; consequently, the ophthalmologist is seeing more patients with adverse ocular side effects secondary to these antineoplastic agents. Many of these drugs cause aggravating ocular irritation (fluorouracil, methotrexate), canalicular fibrosis with epiphora (fluorouracil),
Frederick T. Fraunfelder, S. Martha Meyer   +1 more
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