Results 331 to 340 of about 3,376,621 (386)
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Antineoplastic agents and their oral manifestations
Oral Surgery, Oral Medicine, Oral Pathology, 1977The use of antineoplastic agents is rapidly increasing. A general classification of these drugs and their mechanisms of action is presented. Many of the drugs have an adverse effect on oral tissue, and the practicing dentist today must be well acquainted with these effects.
William K. Bottomley +2 more
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Carcinogenicity of antineoplastic agents in man
Cancer Treatment Reviews, 1984Review of the literature shows that: Anticancer drugs are in all probability mostly also carcinogenic. Alkylating agents such as melphalan, chlorambucil and cyclophosphamide seem to lead to the highest rate of second malignancies. Second malignancies after antitumour drugs are mostly acute leukaemias.
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Antineoplastic Agents. 606. The Betulastatins
Journal of Natural Products, 2018The medicinal potential of the plant pentacyclic triterpene betulin has generated long-term interest focused on various SAR research avenues. The present approach was based on producing further analogues (chimeras) arising from a studied modification of betulin bonded to the Dov-Val-Dil-Dap unit of the powerful anticancer drug dolastatin 10, which ...
George R. Pettit +2 more
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Offsetting toxicity of antineoplastic agents
Journal of Surgical Oncology, 1975AbstractPCO, a yeast extract, offsets at least in part the mitotic inhibitory effect of methotrexate and fluorouracil on bone marrow cells in vitro but increases the antimitotic activity of the drugs on ascites Krebs‐2 carcinoma under similar conditions.
M. Agnes Bernadette Proudfoot +4 more
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CHEMOSTERILANT ACTIVITY OF ANTINEOPLASTIC AGENTS
Transactions of the New York Academy of Sciences, 1974AbstractThirty‐five antineoplastic agents were administered to adult house flies, Musca domestica L., by feeding or injection, and effects of the treatment on the flies' reproductive capacity were determined. For both sexes of the insect the most effective sterilants were alkylating agents; none of the hormonal drugs were active, but one antimetabolite
Alexej B. Bořkovec +2 more
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Chemical carcinogenicity and the antineoplastic agents
American Journal of Health-System Pharmacy, 1984The subject of chemical carcinogenicity is reviewed with discussions of the involved environmental factors, proposed mechanisms of mutagenesis and carcinogenesis, dose-response considerations, secondary tumor development, and an emphasis on the potential carcinogenicity of antineoplastic agents. Although the causes of various cancers are complex, 70-90%
AE Wade, AT Taylor
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1989
New antineoplastic agents are being developed predominantly in industrial laboratories and only to a limited extent in university and other research institutes. The results of so-called screening assays, as conducted especially by the National Cancer Institute, have been disappointing in particular since the testing of many hundreds or thousands of ...
T. Klenner +3 more
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New antineoplastic agents are being developed predominantly in industrial laboratories and only to a limited extent in university and other research institutes. The results of so-called screening assays, as conducted especially by the National Cancer Institute, have been disappointing in particular since the testing of many hundreds or thousands of ...
T. Klenner +3 more
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Ocular Toxicity of Antineoplastic Agents
Ophthalmology, 1983The increased use of chemotherapeutic agents has resulted in longer patient survival; consequently, the ophthalmologist is seeing more patients with adverse ocular side effects secondary to these antineoplastic agents. Many of these drugs cause aggravating ocular irritation (fluorouracil, methotrexate), canalicular fibrosis with epiphora (fluorouracil),
Frederick T. Fraunfelder +1 more
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Transport of Antineoplastic Agents
1974Before an agent can damage a cancer cell, it must be able to pass through the outer cell membrane, also called the plasma membrane. An exception to this rule would be provided by a “membrane-active” compound, which would affect the plasma membrane only and by so doing cause cell death. Antibacterial agents of this type do exist (Hamilton, 1970).
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Antineoplastic Agents and Pregnancy
Obstetrical & Gynecological Survey, 1990Donald C. Doll +2 more
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