Results 31 to 40 of about 50 (48)
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Thrombotic microangiopathies and antineoplastic agents
Néphrologie & Thérapeutique, 2017Thrombotic microangiopathy is a well-described complication of cancer treatment. Its incidence has increased these last decades, as a result of a better awareness of this complication in cancer patients in one hand, but also of a larger array of therapeutic compounds including anti-vascular endothelium growth factor (VEGF) drugs.
Steven Grangé, Paul Coppo
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Antineoplastic Agents. 606. The Betulastatins
Journal of Natural Products, 2018The medicinal potential of the plant pentacyclic triterpene betulin has generated long-term interest focused on various SAR research avenues. The present approach was based on producing further analogues (chimeras) arising from a studied modification of betulin bonded to the Dov-Val-Dil-Dap unit of the powerful anticancer drug dolastatin 10, which ...
George R. Pettit +2 more
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Offsetting toxicity of antineoplastic agents
Journal of Surgical Oncology, 1975AbstractPCO, a yeast extract, offsets at least in part the mitotic inhibitory effect of methotrexate and fluorouracil on bone marrow cells in vitro but increases the antimitotic activity of the drugs on ascites Krebs‐2 carcinoma under similar conditions.
M. Agnes Bernadette Proudfoot +4 more
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Chemical carcinogenicity and the antineoplastic agents
American Journal of Health-System Pharmacy, 1984The subject of chemical carcinogenicity is reviewed with discussions of the involved environmental factors, proposed mechanisms of mutagenesis and carcinogenesis, dose-response considerations, secondary tumor development, and an emphasis on the potential carcinogenicity of antineoplastic agents. Although the causes of various cancers are complex, 70-90%
AE Wade, AT Taylor
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Ocular Toxicity of Antineoplastic Agents
Ophthalmology, 1983The increased use of chemotherapeutic agents has resulted in longer patient survival; consequently, the ophthalmologist is seeing more patients with adverse ocular side effects secondary to these antineoplastic agents. Many of these drugs cause aggravating ocular irritation (fluorouracil, methotrexate), canalicular fibrosis with epiphora (fluorouracil),
Frederick T. Fraunfelder +1 more
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Transport of Antineoplastic Agents
1974Before an agent can damage a cancer cell, it must be able to pass through the outer cell membrane, also called the plasma membrane. An exception to this rule would be provided by a “membrane-active” compound, which would affect the plasma membrane only and by so doing cause cell death. Antibacterial agents of this type do exist (Hamilton, 1970).
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1989
New antineoplastic agents are being developed predominantly in industrial laboratories and only to a limited extent in university and other research institutes. The results of so-called screening assays, as conducted especially by the National Cancer Institute, have been disappointing in particular since the testing of many hundreds or thousands of ...
T. Klenner +3 more
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New antineoplastic agents are being developed predominantly in industrial laboratories and only to a limited extent in university and other research institutes. The results of so-called screening assays, as conducted especially by the National Cancer Institute, have been disappointing in particular since the testing of many hundreds or thousands of ...
T. Klenner +3 more
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Antineoplastic Agents and Pregnancy
Obstetrical & Gynecological Survey, 1990Donald C. Doll +2 more
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Gallium compounds as antineoplastic agents
Current Opinion in Oncology, 2004The purpose of this review is to provide an outline of the basic and clinical information on gallium nitrate as an antineoplastic agent. Although early clinical trials indicated that gallium nitrate had activity against lymphoma and bladder cancer, its subsequent development centered primarily on its effect on bone metabolism and not on its ...
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Antineoplastic and Immunosuppressive Agents [PDF]
Tumori Journal, 1975 D.G. Johns, Alan C. Sartorelli
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