Results 61 to 70 of about 175,055 (304)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Assessment of the implementation of accelerated drug marketing registration procedures for antineoplastic and immunomodulating agents in China: based on 2016–2022 review data

Frontiers in Pharmacology
Objective:Since 2016, China has successively implemented Accelerated Drug Marketing Registration Procedures (ADMRPs) for drugs, including Breakthrough Therapy Drug (BTD), Conditional Approval (CA), and Priority Review and Approval (PRA), which have ...
Yipeng Lan, Xiaofeng Lin, Jialin Yu, Li Wang, Lihua Sun, Lihua Sun, Zhe Huang, Zhe Huang   +7 more
doaj   +1 more source

Infiltrative Lung Diseases: Complications of Novel Antineoplastic Agents in Patients with Hematological Malignancies

Canadian Respiratory Journal, 2008
Infiltrative lung disease is a well-known complication of antineoplastic agents in patients with hematological malignancies. Novel agents are constantly being added to available treatments.
Bobbak Vahid, Paul E Marik
doaj   +1 more source

Antineoplastic multi-drug chemotherapy to sensitize tumors triggers multi-drug resistance and inhibits efficiency of maintenance treatment in glioblastoma cells

EXCLI Journal : Experimental and Clinical Sciences, 2023
Combinations of the well-known antineoplastic agents 5-fluorouracil (5-Fu), cisplatin, and paclitaxel are employed to increase radiotherapy/immunotherapy efficacy against persistent and resistant tumors.
Oguzhan Doganlar, Zeynep Banu Doğanlar, Suat Erdogan, Emre Delen   +3 more
doaj   +1 more source

MicroNIR/chemometrics assessement of occupational exposure to hydroxyurea [PDF]

, 2018
Portable Near Infrared spectroscopy (NIRs) coupled to chemometrics was investigated for the first time as a novel entirely on-site approach for occupational exposure monitoring in pharmaceutical field.
Materazzi, S., Risoluti, R.
core   +2 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Identification of Pharmacological Modulators of HMGB1-Induced Inflammatory Response by Cell-Based Screening [PDF]

, 2013
High mobility group box 1 (HMGB1), a highly conserved, ubiquitous protein, is released into the circulation during sterile inflammation (e.g. arthritis, trauma) and circulatory shock.
A Lahat, AJ Ghio, AM Colangelo, B Cai, B Lu, C Lagathu, C Szabo, Csaba Szabo, D Ditsworth, D Gero, D Gero, Domokos Gerö, E Venereau, EA Park, GY Chen, H Schierbeck, H Selye, H Wang, H Yang, H Yang, H Yang, HE Harris, Huan Yang, J Evankovich, J Szelenyi, John P. Pribis, JR Klune, Katalin Módis, Kevin J. Tracey, KJ Tracey, L Ulloa, ME Bianchi, O Hori, Petra Szoleczky, PJ Barnes, R Bertini, Robert W. Sobol, Sangeeta Chevan, Timothy R. Billiar, U Andersson, Yousef Al-Abed   +40 more
core   +4 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

1ISG-003 Impact of telepharmacy and community pharmacy remote-dispensing on patients on oral antineoplastic agents [PDF]

, 2022
F. Rodríguez-González, Xosé M. Fernández, A Arderiu, O Fando, S Pineda, J Urbina, Manuel Berzosa, Délio Marques Conde   +7 more
openalex   +1 more source

Charge Transfer-oxy Radical Mechanism for Anti-cancer Agents [PDF]

, 1986
The proposal is advanced that anti-cancer drugs generally function by charge transfer resulting in formation of toxic oxy radicals which destroy the neoplasm.
Ames, James R., Cox, O., Elo, Hannu, Kovacic, Peter, Lumme, Paavo, Ryan, Michael D.   +5 more
core   +1 more source