Results 91 to 100 of about 8,664 (277)
Temporal Patterns of Medications Dispensed to Children and Adolescents in a National Insured Population [PDF]
, 2011 This study aimed to comprehensively describe prevalence and temporal dispensing patterns for medications prescribed to children and adolescents in the United States.
A Clavenna +27 more
core +4 more sources
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Semina: Ciências Agrárias, 2010 A revision of the current literature regarding medical management of neurological diseases of dogs and cats is presented. The indications, doses, and duration of the recommended treatment of several medications are reviewed.
Ronaldo Cassimiro da Costa +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Revista Brasileira de Farmácia Hospitalar e Serviços de SaúdeObjective: Considering Collegiate Board Resolution 220 of 2004, which describes the minimum requirements required for the operation of antineoplastic therapy services, the objective of this work was to propose and validate a process for checking and ...
Ester Elena SCHAAB +2 more
doaj +1 more source
c-Jun N-terminal kinase phosphorylation is a biomarker of plitidepsin activity [PDF]
, 2015 This is an open access article distributed under the Creative Commons Attribution License.-- et al.Plitidepsin is an antitumor drug of marine origin currently in Phase III clinical trials in multiple myeloma.
Muñoz Terol, Alberto +1 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Improving the Medicare Part D Program for the Most Vulnerable Beneficiaries [PDF]
, 2007 Discusses some of the obstacles patients experience using Medicare Part D and makes specific recommendations to strengthen the program, such as using simpler, more standard procedures and ensuring that needed counseling support is ...
Jeanne Finberg +2 more
core
Relation between DNA damage measured by comet assay and OGG1 Ser326Cys polymorphism in antineoplastic drugs biomonitoring [PDF]
, 2015 Antineoplastic drugs are hazardous chemical agents used mostly in the treatment of patients with cancer, however health professionals that handle and administer these drugs can become exposed and develop DNA damage.
Brito, Miguel +5 more
core +3 more sources