Results 81 to 90 of about 8,664 (277)

Trends in chemotherapy use for early-stage breast cancer from 2006 to 2019

Breast Cancer Research
Background Little is known about how use of chemotherapy has evolved in breast cancer patients. We therefore describe chemotherapy patterns for women with stage I-IIIA breast cancer in the Optimal Breast Cancer Chemotherapy Dosing (OBCD) Study using data
Jenna Bhimani, Kelli O’Connell, Isaac J. Ergas, Marilyn Foley, Grace B. Gallagher, Jennifer J. Griggs, Narre Heon, Tatjana Kolevska, Yuriy Kotsurovskyy, Candyce H. Kroenke, Cecile. A. Laurent, Raymond Liu, Kanichi G. Nakata, Sonia Persaud, Donna R. Rivera, Janise M. Roh, Sara Tabatabai, Emily Valice, Erin J.A. Bowles, Elisa V. Bandera, Lawrence H. Kushi, Elizabeth D. Kantor   +21 more
doaj   +1 more source

The role of gut microbiota dysbiosis in drug-induced brain injury: mechanisms and therapeutic implications

Frontiers in Cell and Developmental Biology
Drug-induced brain injury (DIBI) results from toxicity, interactions or misuse and is increasingly linked to gut-microbiota dysbiosis operating via the gut–brain axis.
Jinghui Zhai, Yue Zhang, Shuyue Ma, Yingli Zhang, Miao Jin, Huiyu Yan, Sixi Zhang, Sixi Zhang   +7 more
doaj   +1 more source

The diagnostic role of saliva: a review [PDF]

, 2011
As a diagnostic fluid, saliva offers distinctive advantages over serum because it can be collected non-invasively by individuals, even by patient.
Atreja, Gaurav, Bansal, Sanjay, Bansal, Vikram, Garg, Shushant K., Mittal, Sanjeev   +4 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Enhancing the Australian National Health Survey Data for Use in a Microsimulation Model of Pharmaceutical Drug Usage and Cost [PDF]

While static microsimulation models of the tax-transfer system are now available throughout the developed world, health microsimulation models are much rarer.
Ann Harding, Annie Abello, Ben Phillips, Laurie Brown, Sharyn Lymer   +4 more
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Characteristics, treatment patterns, and outcomes in patients with high-risk locally advanced cervical cancer

Cancer Treatment and Research Communications
Objective: To characterize the real-world treatment patterns and outcomes of patients with high-risk locally advanced cervical cancer (HR-LACC). Methods: This retrospective study identified and randomly selected adults diagnosed between 2010 and 2018 ...
Francesca Coutinho, Mugdha Gokhale, Charlotte Doran, Matthew Monberg, Karin Yamada, Lei Chen   +5 more
doaj   +1 more source

Trend Price Analysis of Drug Before and After the Implementation of E-catalogue at the Hospital

Jurnal Manajemen dan Pelayanan Farmasi, 2019
In 2013, Ministry of Health, Republic of Indonesia, launched a new change to drug procurement system, namely e-catalogue, to ensure the availability and affordability of medicines. This system replaces the previous auction drug procurement system.
Yusi Anggriani, Prih Sarnianto, Siti Aisyah, Jenny Pontoan   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source