Results 41 to 50 of about 8,664 (277)

Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study [PDF]

, 2015
BACKGROUND & AIMS: The Drug-Induced Liver Injury Network is conducting a prospective study of patients with DILI in the United States. We present characteristics and subgroup analyses from the first 1257 patients enrolled in the study.
Barnhart, Huiman, Bonkovsky, Herbert L, Chalasani, Naga, Fontana, Robert, Gu, Jiezhun, Lee, William, Navarro, Victor, Reddy, K Rajendar, Serrano, Jose, Stolz, Andrew, Talwalkar, Jayant, United States Drug Induced Liver Injury Network, Watkins, Paul B   +12 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Release of macromolecules from albumin-heparin microspheres [PDF]

, 1992
Hydrophilic microspheres based on albumin-heparin conjugates have been prepared as a macromolecular delivery system. The soluble albumin-heparin conjugate was synthesized and crosslinked in a water-in-oil emulsion with glutaraldehyde to form microspheres
Bae, You Han, Cremers, H.F.M., Cremers, Harry, Feijen, Jan, Kim, Sung Wan, Kwon, Glen S.   +5 more
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Synthesis and Spectroscopic Study of Naphtholic and Phenolic Azo Dyes [PDF]

, 2013
Azo dyes are extremely important in variety of industries for variety of technical purposes. Hence, a series of naphtholic azo dyes 1-9 were synthesized via diazotization of substituted aniline derivatives followed by azo coupling with 2-naphthol.
Ajani, Alice O, Ajani, O. O., Akinremi, O. E., Anake, W. U., Edobor-Osoh, A.   +4 more
core  

Water treatment plants and pharmaceutical residues in Catalonia and Italy [PDF]

, 2014
This study analyses the occurrence of commonly administered pharmaceuticals in urban and treated wastewater and surface waters in Catalonia and Italy, reviewing recently published investigations.
Petrovic, Mira, Verlicchi, Paola
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Pharmacovigilance Program impact on notifications of adverse reactions to antineoplastic drug in a university hospital

Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde
Objective: To evaluate the Pharmacovigilance Program impact on notifications of adverse reactions to antineoplastic drugs (ADR) in a university hospital.
Carlos Alberto WAYHS, Tatiana Von DIEMEN   +1 more
doaj   +1 more source

Efficacy of Two Cleaning Solutions for the Decontamination of 10 Antineoplastic Agents in the Biosafety Cabinets of a Hospital Pharmacy [PDF]

, 2017
Objective: This study aimed to evaluate two cleaning solutions for the chemical decontamination of antineoplastic agents on the surfaces of two biosafety cabinets routinely used for chemotherapy preparation in a hospital pharmacy.
Anastasi, Marco, Bonnabry, Pascal, Fleury-Souverain, Sandrine, Odou, Pascal, Queruau Lamerie, Thomas, Rudaz, Serge   +5 more
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source