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Clinical value of antineutrophil cytoplasmic antibodies
Current Rheumatology Reports, 2000This article presents a brief review of the clinical value of antineutrophil cytoplasmic antibodies (ANCA) in the diagnosis and management of patients with various forms of vasculitis. ANCA assay methodology and testing recommendations are reviewed. The patterns of reactivity of ANCA observed by indirect immunofluorescence, the antigens recognized by ...
V, Rus, B S, Handwerger
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Antineutrophil Cytoplasmic Antibodies in Diffuse Panbronchiolitis
Respiration, 1999<i>Background:</i> There are some reports of the coexistence of chronic suppurative lung diseases such as cystic fibrosis and systemic vasculitis. Diffuse panbronchiolitis has the same characteristics as chronic recurrent sinopulmonary infection and respiratory bronchiolitis.
Y, Sugiyama, S, Kitamura
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Antineutrophil cytoplasmic antibodies (ANCA) and vasculitis
Clinical Rheumatology, 1990The demonstration of autoantibodies to different myeloid lysozomal enzymes has opened a new area for the study of vasculitic syndromes. Autoantibodies producing a granular cytoplasmic staining by IIF (c-ANCA, probably directed to a putative serine protease) are closely associated with Wegener's granulomatosis.
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The antineutrophil cytoplasmic antibody–associated vasculitides
The American Journal of Medicine, 2004Wegener's granulomatosis, microscopic polyangiitis, and Churg-Strauss syndrome are small- to medium-vessel vasculitides linked by overlapping pathology and the presence of antineutrophil cytoplasmic antibodies (ANCA). Commonly referred to as the ANCA-associated vasculitides, these diseases are challenging to diagnose and to treat.
Philip, Seo, John H, Stone
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Antineutrophil cytoplasmic antibody-associated neutropenia
European Journal of Internal Medicine, 2004BACKGROUND: Antineutrophil cytoplasmic antibodies (ANCA) can be associated with various disorders. However, their association with neutropenia has never been reported. METHODS: Nine patients with chronic unexplained neutropenia and ANCA were studied. Clinical charts were extensively analyzed and all patients underwent hematological and immunological ...
Paul, Coppo +7 more
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Antineutrophil cytoplasmic antibody-associated vasculitis
Current Opinion in Nephrology & HypertensionPurpose of review This review focuses on latest developments in managing antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV), a systemic autoimmune condition characterized by inflammation and necrosis of small blood vessels due to circulating autoantibodies that target neutrophilic granules.
Raghunandan, Konda +2 more
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Sialadenitis in Antineutrophil Cytoplasmic Antibodies Vasculitis
Journal of The Association of Physicians of IndiaGranulomatosis with polyangiitis (GPA) is a pauci-immune vasculitis typically involving upper and lower respiratory tract involvement and crescentic glomerulonephritis. Salivary gland involvement in GPA is rare. When it occurs in GPA, it is commonly seen with sinonasal and lung involvement and rarely with renal involvement.
Aditi, Patankar +3 more
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American Journal of Respiratory and Critical Care Medicine, 2019
Abstract Rationale Eosinophilic granulomatosis with polyangiitis (eGPA) is a small-vessel vasculitis where 40% of patients present with serum antineutrophil cytoplasmic antibodies (ANCAs). We examined the presence and clinical relevance of sputum ANCAs in the serum ANCA− patients with eGPA.
Manali, Mukherjee +13 more
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Abstract Rationale Eosinophilic granulomatosis with polyangiitis (eGPA) is a small-vessel vasculitis where 40% of patients present with serum antineutrophil cytoplasmic antibodies (ANCAs). We examined the presence and clinical relevance of sputum ANCAs in the serum ANCA− patients with eGPA.
Manali, Mukherjee +13 more
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ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES IN THE CLASSIFICATION OF VASCULITIS
Annual Review of Medicine, 1996▪ Abstract Two important types of antineutrophil cytoplasmic antibodies (ANCA) have been identified: anti-proteinase 3 and anti-myeloperoxidase antibodies. In the appropriate clinical setting, the presence of either is virtually diagnostic of the subset of vasculitis that includes Wegener's granulomatosis, microscopic polyangiitis (microscopic ...
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Antineutrophil cytoplasmic antibody-associated vasculitides
Joint Bone Spine, 2007The identification of antineutrophil cytoplasmic antibodies (ANCA) proved a major breakthrough in the classification, diagnosis, monitoring, and understanding of vasculitides. Vasculitides associated with ANCA selectively affect the small vessels; they include Wegener granulomatosis, microscopic polyangiitis, and Churg-Strauss syndrome.
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