Results 91 to 100 of about 17,058 (185)

Chagas Disease Drug Discovery in Latin America-A Mini Review of Antiparasitic Agents Explored Between 2010 and 2021. [PDF]

Front Chem, 2021
de Oliveira RG, Cruz LR, Mollo MC, Dias LC, Kratz JM.   +4 more
europepmc   +1 more source

Chemokines in Alzheimer's Disease: Early Defence, Late Damage and the Impact of Sex and Infection

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 2, August 2026.
ABSTRACT Chemokines constitute a versatile signalling network maintaining homeostasis and glia–neuron communication in the healthy brain but become progressively dysregulated during aging and Alzheimer's disease (AD). This review examines how chemokine systems transition from tightly regulated homeostatic signals to drivers of chronic neuroinflammation
Blanca I. Aldana, Kristine Freude
wiley   +1 more source

Opportunities and Challenges in Developing a Cryptosporidium Controlled Human Infection Model for Testing Antiparasitic Agents. [PDF]

ACS Infect Dis, 2021
Jumani RS, Blais J, Tillmann HC, Segal F, Wetty D, Ostermeier C, Nuber N, Lakshman J, Aziz N, Chandra R, Chen WH, Chappell CL, Diagana TT, Manjunatha UH.   +13 more
europepmc   +1 more source

Vectors and Vector‐Borne Diseases: Biology, Epidemiology and Integrated Control Strategies

Journal of Applied Entomology, Volume 150, Issue 7, Page 990-1015, August 2026.
ABSTRACT Vector‐Borne Diseases (VBDs), transmitted by arthropods such as mosquitoes, ticks, fleas and sandflies, represent a significant threat to global health. These diseases can be caused by a variety of pathogens, including bacteria, viruses, protozoa, and helminths.
Roberta Rinaldi, Carmen Scieuzo, Federica De Stefano, Luca Masucci, Patrizia Falabella   +4 more
wiley   +1 more source

Synergistic Effects of Artesunate in Combination with Amphotericin B and Miltefosine against Leishmania infantum: Potential for Dose Reduction and Enhanced Therapeutic Strategies

Antibiotics
Leishmaniasis is a tropical infectious disease caused by Leishmania parasites. The disease can be spread by the bite of an infected sand fly. Currently, five chemotherapeutic drugs are available in leishmaniasis treatment.
Nuchpicha Intakhan, Atiporn Saeung, Sonia M. Rodrigues Oliveira, Maria de Lourdes Pereira, Wetpisit Chanmol   +4 more
doaj   +1 more source

Toward Chromoselective Transformations in Biological Systems: Perspectives and Challenges

Angewandte Chemie International Edition, Volume 65, Issue 31, 27 July 2026.
Controlling biological systems with small‐molecule chromophores has evolved into a powerful strategy and is applied from chemical biology to medicine. However, the complexity of in vivo systems cannot be matched by a single wavelength of light. Developing methods to combine and individually control multiple chromophores is crucial.
Nadja A. Simeth
wiley   +1 more source

Probing 5‐Nitroimidazole‐Triazole Hybrids as Potential Anti‐Kinetoplastid Agents: Synthesis and In Vitro Efficacy

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
A series of 5‐nitroimidazole‐1,2,3‐triazole hybrids was synthesised and evaluated for antitrypanosomatid activity to assess their potential as treatments against leishmaniasis and trypanosomiasis. No notable in vitro activity against Leishmania was detected.
Liandi Ferreira, Gideon D. Badenhorst, Janine Aucamp, Keisuke Suganuma, David D. N’Da   +4 more
wiley   +1 more source

Pyridyl‐Imidazopyridine Derivatives Displaying Submicromolar Activity Against Trypanosoma cruzi

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Previously reported pyridyl‐thiazoles and highly active imidazopyridines against Trypanosoma cruzi inspired the design of a new series of pyridyl‐substituted imidazopyridines. Among the synthesized compounds, 5h emerged as the most promising derivative, displaying potent trypanocidal activity (EC50 = 0.16 μM), excellent selectivity (SI > 1250), and ...
Ana Carolina Rocha Barreto, Kelly Lopes Figueira, Raquel Azevedo, Ketlym da Conceição, Ludmila de Ferreira de Almeida Fiuza, Luan dos Santos Vianna, Thiago Apolinário de Moraes, Wagner Alves de Souza Júdice, Maria de Nazaré Correia Soeiro, Jones Limberger   +9 more
wiley   +1 more source

Does Ivermectin Pollute the Surroundings of Swine Farms?

Veterinary Medicine and Science
Pharmaceuticals are emerging environmental pollutants, with macrocyclic lactones like ivermectin raising concerns due to their widespread use and persistence.
Alicia Maria Carrillo Heredero, Elena Butovskaya, Giulia Segato, Luigino Calzetta, Simonetta Menotta, Simone Bertini   +5 more
doaj   +1 more source

Novel Hit Compounds Against a Neglected Sexually Transmitted Infection: Synthesis and Trichomonacidal Activity of 1,3-Thiazolidin-4-One Derivatives

Pharmaceutics
Background: Infections caused by the protozoan Trichomonas vaginalis affect millions of people worldwide and are responsible for one of the most common sexually transmitted diseases.
Alexia Brauner de Mello, Melinda G. Victor, Wilson Cunico, Jorge Fernández-Villalba, Frederico Schmitt Kremer, Lucas Mocellin Goulart, Juan José García-Rodríguez, Camila Belmonte Oliveira, Alexandra Ibáñez-Escribano   +8 more
doaj   +1 more source