Results 131 to 140 of about 32,131 (285)
Menthol carbonates as potent antiparasitic agents: synthesis and in vitro studies along with computer-aided approaches. [PDF]
BMC Complement Med Ther, 2022 Clemente CM, Robledo SM, Ravetti S.
europepmc +1 more source
Exploring 6‐Hydroxy‐3‐Aryl/Heteroarylcoumarins as Promising Candidates Against Trypanosoma cruzi
ChemMedChem, Volume 21, Issue 9, 14 May 2026.New therapies are urgently needed for Chagas disease, and screening of 6‐hydroxy‐3‐aryl/heteroarylcoumarin derivatives identified highly selective compounds with potent activity against T. cruzi. In particular, derivative 1f showed submicromolar trypomastigote potency, dual‐stage activity, and inhibition of amastigote‐to‐trypomastigote differentiation,
C. N. Pereira +7 more
wiley +1 more source
Electron Transfer-oxy Radical Mechanism for Anti-cancer Agents: 9-anilinoacridines [PDF]
, 1987 A possible mode of action involving electron transfer is advanced for the 9- anilinoacridines. The mechanism entails formation of toxic oxy radicals which destroy the neoplasm.
Ames, James R. +2 more
core +1 more source
Computational Design of Azole Derivatives as Multifunctional Agents for Alzheimer's Disease
Applied Organometallic Chemistry, Volume 40, Issue 5, May 2026.A series of 19 azole derivatives were evaluated using bioinformatic tools and density functional theory in the context of multifunctional agents for Alzheimer's disease and were classified as potential antioxidant, distributor, and suppressor agents. ABSTRACT Alzheimer's disease (AD) is the most common form of dementia, characterized by multifactorial ...
Nicolás Puentes‐Díaz +5 more
wiley +1 more source
Contemporary Applications of Chemical Libraries for Drug Discovery and Methods for Their Synthesis
ChemistryEurope, Volume 4, Issue 5, May 2026.Screening of chemical libraries has over the past decades become a cornerstone of drug discovery. Today, a broad range of chemical libraries exist but they are often not well described in terms of diversity. This review describes current efforts which aim to visualize chemical diversity in compound collections and discuss current trends in synthetic ...
Tobias N. Hansen, Nils J. V. Hansen
wiley +1 more source
European Eating Disorders Review, Volume 34, Issue 3, Page 749-769, May 2026.ABSTRACT Background Eating disorders are debilitating illnesses that often co‐occur with other psychiatric disorders and somatic diseases. Evidence indicates that the incidence of eating disorders has been increasing. We first examine the landscape of EDs over time, including the COVID‐19 period, via assessing the incidence of anorexia nervosa (AN ...
Nadia Micali +4 more
wiley +1 more source
Repurposing and Reformulation of the Antiparasitic Agent Flubendazole for Treatment of Cryptococcal Meningoencephalitis, a Neglected Fungal Disease [PDF]
, 2018 Gemma L. Nixon +15 more
openalex +1 more source
Food Frontiers, Volume 7, Issue 3, May 2026.This article highlights the crucial role of starter culture selection in shaping the peptide profile of fermented dairy drinks. Using high‐throughput peptidome profiling, the study demonstrates that different starter cultures yield distinct quantities and types of bioactive peptides, with excessive microbial combinations potentially reducing peptide ...
Martina Banić +6 more
wiley +1 more source
Chagas Disease Drug Discovery in Latin America-A Mini Review of Antiparasitic Agents Explored Between 2010 and 2021. [PDF]
Front Chem, 2021 de Oliveira RG +4 more
europepmc +1 more source
Health Science Reports, Volume 9, Issue 5, May 2026.ABSTRACT Background and Aims Scabies remains a major cause of morbidity among Bangladeshi children, particularly in overcrowded and resource‐limited settings. This perspective synthesizes current evidence to contextualize the surge of pediatric scabies outbreaks reported across Bangladesh in 2025.
Hemayet Hossain +7 more
wiley +1 more source