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Efficacy of antiparkinson agents in preventing antipsychotic-induced extrapyramidal symptoms.
The types of extrapyramidal syndrome (EPS) reactions produced by antipsychotic agents and the prophylactic use of antiparkinson agents in preventing EPS are reviewed. EPS are classified as akathisias, dystonias, parkinson-like symptoms and tardive dyskinesia, and have a varied incidence reported to range from 10.6 to 100%.
John E. Murphy, Ronald B. Stewart
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Carotenoids as Antiparkinson Agents
, 2021Parkinson’s disease (PD) is a neurodegenerative disease associated with the loss of dopaminergic neurons in the portions of the brain via multiple pathological mechanisms. Despite the fact that enormous progress occurred in the cure of Parkinson’s disorder, but the incidence and risk of this disease is increasing alarmingly over the past few decades ...
S. Dewanjee +5 more
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Potential for abuse of antiparkinson agents.
Psychiatric Services, 1982Hospital &‘ Community Psychiatrj is expanding its roster of peer reviewers for manuscripts submitted for publication. Professionals in the mental health disciplines who are qualified to serve as peer reviewers are invited to contact the editor. Reviewers must have significant publications in their specialty area, be abreast of the liteEature in that ...
J. M. Smith
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ChemInform Abstract: SOME NEW PIPERAZINO DERIVATIVES AS ANTIPARKINSON AND ANTICONVULSANT AGENTS
AbstractThe piperazino derivatives 1–7 were synthesized and evaluated for their antiparkinson activity on oxotremorine‐induced tremors and reserpine‐induced rigidity. The same compounds were screened for their anticonvulsant activity. Compounds 1, 3, 4 and 5 showed promising antiparkinson activity.
Jolly Agarwal +5 more
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Reactions to Antiparkinson Agents
, 1987The cardiovascular effects are dose-related. Low doses can cause transient bradycardia; moderate or high doses can cause tachycardia, palpitation, and arrhythmias (due to blockage of vagal effects on the S-A node).
F. L. Tornatore +3 more
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REVERSAL OF SOME THERAPEUTIC EFFECTS OF AN ANTIPSYCHOTIC AGENT BY AN ANTIPARKINSONISM DRUG
Data are presented from a multidimensional, longitudinal study in 10 acute schizophrenics which indicate that the addition of benztropine to haloperidol reversed the course of some of the therapeutic changes. The nontherapeutic interaction was selective involving what may be called social avoidance behavior but not the cognitive integrative ...
Man Mohan Singh, James M. Smith
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Quantitative Determination of Some Synthetic Antiparkinsonism Agents
Nonaqueous titrimetry was employed to estimate quantitatively some of the compounds which are useful in treating Parkinsonism. The method was applied to both the crystalline material and their dosage forms. This technique was found to yield results which agreed well with those obtained by either the official procedures or by methods submitted by the ...
L.G. Chatten, William J. Racz
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[Immunotropic activity of a potential antiparkinson agent himantane].
N-(Adamant-2-yl) hexamethyleneimine hydrochloride (A-7, himantane), a new potential antiparkinsonian drug belonging to the class of aminoadamantyl derivatives, exhibits pronounced immunomodulant activity in a therapeutic dose of 10 mg/kg. A single intraperitoneal injection of himantane stimulated a high B-lymphocyte activity in mice over a period of 21
G I Nezhinskaia +3 more
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Potential antiparkinsonism agents. Quinuclidinyl benzhydryl ethers
Jonas Nilsson +2 more
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