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Quantitative Determination of Some Synthetic Antiparkinsonism Agents

Journal of Pharmaceutical Sciences, 1968
Nonaqueous titrimetry was employed to estimate quantitatively some of the compounds which are useful in treating Parkinsonism. The method was applied to both the crystalline material and their dosage forms. This technique was found to yield results which agreed well with those obtained by either the official procedures or by methods submitted by the ...
L G, Chatten, W J, Racz
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Reactions to Antiparkinson Agents

1987
The cardiovascular effects are dose-related. Low doses can cause transient bradycardia; moderate or high doses can cause tachycardia, palpitation, and arrhythmias (due to blockage of vagal effects on the S-A node).
Frank L. Tornatore   +3 more
openaire   +1 more source

Some New Piperazino Derivatives as Antiparkinson and Anticonvulsant Agents

Archiv der Pharmazie, 1983
AbstractThe piperazino derivatives 1–7 were synthesized and evaluated for their antiparkinson activity on oxotremorine‐induced tremors and reserpine‐induced rigidity. The same compounds were screened for their anticonvulsant activity. Compounds 1, 3, 4 and 5 showed promising antiparkinson activity.
J C, Agarwal   +5 more
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Metabolism of antiparkinson agent dopazinol by rat liver microsomes.

Drug Metabolism and Disposition, 1990
Metabolism of dopazinol (DZ) by liver microsomes from control and phenobarbital- and 3-methylcholanthrene-treated rats has been investigated. Liver microsomes from control and treated rats metabolized DZ to N-despropyl-DZ (39-53% of total metabolites); 8-hydroxy-DZ, a catechol metabolite (32-39%); and 5- or 6-hydroxy-DZ (12-20%).
K P, Vyas   +4 more
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Potential antiparkinsonism agents. Quinuclidinyl benzhydryl ethers

Journal of Medicinal Chemistry, 1969
J L, Nilsson, J, Wågermark, R, Dahlbom
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