Results 191 to 200 of about 554,154 (221)
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Platelets and Antiphospholipid Antibodies
Lupus, 1996The involvement of platelets in the antiphospholipid syndrome is complex and the full pathogenic significance is not fully understood. The binding of aPL antibodies to the platelet membrane may result in the thrombopenia and further haemostatic activation.
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JCR: Journal of Clinical Rheumatology, 1997
Although significant progress has been made during the last decade in our knowledge of the antiphospholipid antibodies (aPL), there are two major questions in clinical practice that require further guidelines: Indications for aPL determination and laboratory tests to choose. This article reviews the main clinical indications to search for aPL (systemic
R, Cervera, J, Font, R A, Asherson
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Although significant progress has been made during the last decade in our knowledge of the antiphospholipid antibodies (aPL), there are two major questions in clinical practice that require further guidelines: Indications for aPL determination and laboratory tests to choose. This article reviews the main clinical indications to search for aPL (systemic
R, Cervera, J, Font, R A, Asherson
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Antiphospholipid antibodies and malignancies
Autoimmunity Reviews, 2010Since the 1980s it is known that an important thrombogenic mechanism is mediated by antiphospholipid antibodies (aPL). Aim of this review is to discuss how much aPL presence may worsen the thrombophilic state of neoplastic patients and how much cancer may worsen and extend the thrombophilic state of patients with Antiphospholipid Syndrome (APS). In the
TINCANI, Angela +2 more
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Noncriteria antiphospholipid antibodies in antiphospholipid syndrome
International Journal of Laboratory HematologyAbstractAntiphospholipid syndrome (APS) is an autoimmune disease characterized by thrombotic manifestations and/or obstetric complications in patients with persistently positive antiphospholipid antibodies (aPL). aPL are a heterogeneous group of autoantibodies, but only lupus anticoagulant, anticardiolipin (aCL), and antibeta2‐glycoprotein I antibodies
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Antiphospholipid Antibodies in Children
Seminars in Thrombosis and Hemostasis, 1998Lupus anticoagulant (LA) is made up of heterogeneous IgG and IgM antibodies that prolong clotting times in vitro and is associated with an increased rate of both thrombosis and hemorrhage in vivo, although thrombosis is far more common. Many mechanisms of action have been explored, but none explains the coagulation abnormality of every sample tested ...
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Antiphospholipid antibody and antiphospholipid antibody syndrome.
Current opinion in rheumatology, 1992Over the past year, many reports have been published on a variety of clinical manifestations related to antiphospholipid antibodies. The low prevalence of anticardiolipin antibodies with the rare occurrence of thrombosis and a low rate of fetal loss in studies in Malaysia and China showed a potential role for local factors.
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Antiphospholipid Antibody Syndromes
Rheumatic Disease Clinics of North America, 1989There is no doubt that in some individuals the presence of antibodies to negatively charged phospholipids currently measured as the lupus anticoagulant, a biologically false positive VDRL, and anticardiolipin antibodies is associated with certain clinical features, in particular, a predisposition to both arterial and venous thrombosis and, in women, to
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Antibody–Drug Conjugates: Smart Chemotherapy Delivery Across Tumor Histologies
Ca-A Cancer Journal for Clinicians, 2022Shanu Modi +2 more
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Non-Criteria Antiphospholipid Antibodies in Antiphospholipid Syndrome: Diagnostic Value Added
Frontiers in Immunology, 2022Feng Sun, Jianping Guo, Hongjiang Liu
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