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The antiphospholipid antibody syndrome
Current Opinion in Ophthalmology, 2000Antiphospholipid syndrome includes elevation of either the lupus anticoagulant titer or the anticardiolipin antibody titer on two occasions, separated by 6 weeks in a patient with an episode of thrombosis. The eye is involved frequently in patients with antiphospholipid syndrome. Patients with retinal vascular disease and none of the usual risk factors
J P, Bolling, G C, Brown
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Antiphospholipid antibody and antiphospholipid antibody syndrome
Current Opinion in Rheumatology, 1991New details have been added to the description of the antiphospholipid antibody syndrome. These include quantitation of risk of stroke; delineation of an associated acute occlusive vasculopathy syndrome, including its pathology; increased awareness of the association of adrenal insufficiency with antiphospholipid antibody; new demonstration of ...
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Antiphospholipid antibodies and the antiphospholipid antibody syndrome
Journal of the American Academy of Dermatology, 1997The antiphospholipid antibody syndrome is a multiple-system disorder characterized by persistently elevated antiphospholipid antibodies and/or arterial or venous thrombosis, thrombocytopenia, or recurrent spontaneous abortion. Anticardiolipin antibodies and the lupus anticoagulant are different classes of antiphospholipid antibodies associated with ...
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ANTIPHOSPHOLIPID ANTIBODY SYNDROME
Rheumatic Disease Clinics of North America, 1992The antiphospholipid syndrome is now well recognized and is separable from SLE, but better quantitation of both the clinical elements and the serologic definitions is still needed. It is likely for autoimmune but not for infection-induced aPL that the antigen is not phospholipid itself but a complex formed by phospholipid and beta 2 glycoprotein I ...
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Antiphospholipid syndrome, antiphospholipid antibodies, and atherosclerosis
Current Atherosclerosis Reports, 2001The antiphospholipid syndrome is characterized by arterial and venous thrombosis, as well as pregnancy morbidity, in the presence of elevated levels of antiphospholipid antibodies. These autoantibodies have procoagulant activity, as they affect platelets, humoral coagulation factors, and endothelial cells.
Y, Sherer, Y, Shoenfeld
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Atherogenic Antiphospholipid Antibodies in Antiphospholipid Syndrome
Annals of the New York Academy of Sciences, 2007Abstract: Macrophage uptake of oxidized LDL (oxLDL) plays a critical role in early stages of atherosclerosis. We previously reported that oxLDL forms stable complexes with β2‐glycoprotein I (β2GPI), and that these complexes were frequently present in the sera of patients with systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS ...
Kazuko, Kobayashi +2 more
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Atherosclerosis, Antiphospholipid Syndrome, and Antiphospholipid Antibodies
Frontiers in Bioscience, 2007In antiphospholipid syndrome (APS) patients, some antiphospholipid antibodies (APA) are directed against negatively-charged phospholipids, while other APA are specific for phospholipid-proteins such as beta2-glycoprotein I (beta2GPI). Increased levels of oxidized low density lipoproteins (oxLDL) are present in atherosclerosis patients and these ...
Danielle, Nicolo +2 more
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Antiphospholipid antibodies, antiphospholipid syndrome and infections
Autoimmunity Reviews, 2008Since the association between antiphospholipid antibodies (aPL) and syphilis was first described, many other viral, bacterial and parasitic infections have been shown to induce antiphospholipid antibodies, notably anticardiolipin antibodies (aCL). A review of the literature shows that while aCL occur frequently in viral infections, particularly in HIV (
Damien, Sène +2 more
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Antiphospholipid Antibody Syndromes
Rheumatic Disease Clinics of North America, 1989There is no doubt that in some individuals the presence of antibodies to negatively charged phospholipids currently measured as the lupus anticoagulant, a biologically false positive VDRL, and anticardiolipin antibodies is associated with certain clinical features, in particular, a predisposition to both arterial and venous thrombosis and, in women, to
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Antiphospholipid Antibodies and the Antiphospholipid Syndrome: Pathogenic Mechanisms
Seminars in Thrombosis and Hemostasis, 2008Antiphospholipid antibodies (Abs) are associated with thrombosis and are a risk factor for recurrent pregnancy loss and obstetric complications in patients with the antiphospholipid syndrome. It is generally accepted that the major autoantigen for aPL Abs is beta (2) glycoprotein I, which mediates the binding of aPL Abs to target cells (i.e ...
S. S. Pierangeli +8 more
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