Results 1 to 10 of about 2,611 (175)

Model of Chronic Itch in Aged Mice: Beneficial Effects of Drugs Affecting Descending Modulatory Systems [PDF]

Acta Dermato-Venereologica
Pruritus in the elderly, particularly those cases without skin dryness or other identifiable causes, makes treatment challenging due to the lack of evidence regarding the therapeutic effects of antipruritics. This study proposes an age-related alloknesis
Go Kojima, Eriko Komiya, Kotaro Honda, Takahide Kaneko, Yasushi Suga, Mitsutoshi Tominaga, Kenji Takamori   +6 more
doaj   +3 more sources

Antipruritic Effect of Topical Acetaminophen Gel in Histaminergic and Non-histaminergic Itch Provocation: A Double-blind, Vehicle-controlled Pilot Study [PDF]

Acta Dermato-Venereologica, 2022
There is a need for new topical antipruritics that are effective on many types of itch. This study examined the antipruritic efficacy of a new formulation of topical acetaminophen.
Leigh A. Nattkemper, Kaining Zhi, Kaeli E. Romero, Serena M. Shah, Teresa Ju, Kayla Fourzali, Rachel Shireen Golpanian, Flor MacQuhae, Yiong Huak Chan, David B. Lebo, Gil Yosipovitch   +10 more
doaj   +3 more sources

Improvement in Irretractable Pruritus With Intrahepatic Portosystemic Shunt Embolization: From MAID to a New Lease on Life [PDF]

Case Reports in Hepatology
Pruritus is a common, often debilitating symptom of liver disease. While most commonly seen in the setting of cholestasis and biliary obstruction, intrahepatic portosystemic shunts (PSSs) may also present with pruritus. The pathophysiology of intractable
Amitesh Bagha, Ali Helmi, Arash Jaberi, Gideon Hirschfield, Kristel Leung   +4 more
doaj   +2 more sources

Combination of Low-dose Nalbuphine and Morphine in Patient-controlled Analgesia Decreases Incidence of Opioid-related Side Effects

Journal of the Formosan Medical Association, 2009
The addition of ultra-low-dose naloxone to patient-controlled analgesia (PCA) with morphine reduces opioid-related side effects. Nalbuphine, a mixed opioid agonist–antagonist, may be able to attenuate opioid-related side effects.
Yu-Chang Yeh, Tzu-Fu Lin, Hung-Chi Chang, Wing-Sum Chan, Yong-Ping Wang, Chen-Jung Lin, Wei-Zen Sun   +6 more
doaj   +2 more sources

A clinical continuum of aquagenic pruritus, aquadynia, and aquagenic urticaria responsive to β-blockers [PDF]

Journal of Allergy and Clinical Immunology: Global
β-Blockers have shown promising effects in preventing aquagenic pruritus, but they may also have a role in preventing aquagenic urticaria and aquadynia.
Evelien M. Hutten, MD, Inger F.A. Bocca-Tjeertes, MD, PhD, Rick G. Pleijhuis, MD, PhD   +2 more
doaj   +2 more sources

Natural history of liver disease in a large international cohort of children with Alagille syndrome: Results from the GALA study

Hepatology, EarlyView., 2022
Natural history of liver disease in a large international cohort of children with Alagille syndrome: Results from the GALA study. Abstract Background and Aims Alagille syndrome (ALGS) is a multisystem disorder, characterized by cholestasis. Existing outcome data are largely derived from tertiary centers, and real‐world data are lacking.
Shannon M. Vandriel, Li‐Ting Li, Huiyu She, Jian‐She Wang, Melissa A. Gilbert, Irena Jankowska, Piotr Czubkowski, Dorota Gliwicz‐Miedzińska, Emmanuel M. Gonzales, Emmanuel Jacquemin, Jérôme Bouligand, Nancy B. Spinner, Kathleen M. Loomes, David A. Piccoli, Lorenzo D'Antiga, Emanuele Nicastro, Étienne Sokal, Tanguy Demaret, Noelle H. Ebel, Jeffrey A. Feinstein, Rima Fawaz, Silvia Nastasio, Florence Lacaille, Dominique Debray, Henrik Arnell, Björn Fischler, Susan Siew, Michael Stormon, Saul J. Karpen, Rene Romero, Kyung Mo Kim, Woo Yim Baek, Winita Hardikar, Sahana Shankar, Amin J. Roberts, Helen M. Evans, M. Kyle Jensen, Marianne Kavan, Shikha S. Sundaram, Alexander Chaidez, Palaniswamy Karthikeyan, Maria Camila Sanchez, Maria Lorena Cavalieri, Henkjan J. Verkade, Way Seah Lee, James E. Squires, Christina Hajinicolaou, Chatmanee Lertudomphonwanit, Ryan T. Fischer, Catherine Larson‐Nath, Yael Mozer‐Glassberg, Cigdem Arikan, Henry C. Lin, Jesus Quintero Bernabeu, Seema Alam, Deirdre A. Kelly, Elisa Carvalho, Cristina Targa Ferreira, Giuseppe Indolfi, Ruben E. Quiros‐Tejeira, Pinar Bulut, Pier Luigi Calvo, Zerrin Önal, Pamela L. Valentino, Dev M. Desai, John Eshun, Maria Rogalidou, Antal Dezsőfi, Sabina Wiecek, Gabriella Nebbia, Raquel Borges Pinto, Victorien M. Wolters, María Legarda Tamara, Andréanne N. Zizzo, Jennifer Garcia, Kathleen Schwarz, Marisa Beretta, Thomas Damgaard Sandahl, Carolina Jimenez‐Rivera, Nanda Kerkar, Jernej Brecelj, Quais Mujawar, Nathalie Rock, Cristina Molera Busoms, Wikrom Karnsakul, Eberhard Lurz, Ermelinda Santos‐Silva, Niviann Blondet, Luis Bujanda, Uzma Shah, Richard J. Thompson, Bettina E. Hansen, Binita M. Kamath, The Global ALagille Alliance (GALA) Study Group   +93 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Androgenic anabolic steroid-induced liver injury: two case reports assessed for causality by the updated Roussel Uclaf Causality Assessment Method (RUCAM) score and a comprehensive review of the literature

BMJ Open Gastroenterology, 2020
Background Anabolic androgenic steroids (AAS) usage is widespread and increasing. AAS drug-induced liver injury (DILI) is recognised but its clinical course and management is poorly described.
Mark R Thursz, Robin Daniel Abeles, Matthew Foxton, Shahid Khan, Robert Goldin, Belinda Smith, Suman Verma   +6 more
doaj   +1 more source

A New Generation of Treatments for Itch

Acta Dermato-Venereologica, 2020
For decades, antihistamines have been the mainstay of treatment for chronic pruritus, yet they often only work by making patients drowsy and forgetful of their itch.
Emilie Fowler, Gil Yosipovitch
doaj   +1 more source

Antipruritic Effect of Nalbuphine, a Kappa Opioid Receptor Agonist, in Mice: A Pan Antipruritic [PDF]

Molecules, 2021
Antipruritic effects of kappa opioid receptor (KOR) agonists have been shown in rodent models of acute and chronic scratching (itchlike behavior). Three KOR agonists, nalfurafine, difelikefalin, and nalbuphine, are in clinical studies for antipruritic effects in chronic itch of systemic and skin diseases.
Inan, Saadet, Dun, Nae, Cowan, Alan
openaire   +3 more sources