Results 111 to 120 of about 2,611 (175)

Aprepitant as an Antipruritic Agent?

New England Journal of Medicine, 2009
To the Editor: The Sezary syndrome is a leukemic, cutaneous, epidermotropic T-cell lymphoma. Pruritus, insomnia, and depression impair the quality of life and can lead to suicide.1 Substance P is a key mediator of pruritus.2 An increase in the expression of its receptor, neurokinin-1, has been reported on keratinocytes in pruritic skin diseases.3 ...
Arnaud Duval, Louis Dubertret
openaire   +1 more source

AMINOPHYLLINE AS AN ANTIPRURITIC AGENT

Archives of Dermatology and Syphilology, 1947
A GENERAL report on the use of theophylline ethylenediamine (aminophylline) by injection as an antipruritic agent was presented in a previous paper. 1 It was demonstrated that this agent was most effective when administered intravenously. However, when the drug was given by this route, disconcerting immediate reactions, and even possible fatal ...
openaire   +2 more sources

Evaluation of antipruritic drugs in normal volunteers

Clinical Pharmacology & Therapeutics, 1963
The antipruritic effect of trimeprazine and ergotamine was evaluated in medical students by use of the double‐blind technique. Itch was induced by Mucuna pmriens (cowage) ointment. Ergotamine tartrate was found to be ineffective, whereas no definite opinion could be formed regarding trimeprazine tartrate.
G V, JOGLEKAR, J H, BALWANI, G S, MUTALIK   +2 more
openaire   +2 more sources

Screening Topical Antipruritics: A Histamine-Induced Itch Human Model

Skin Pharmacology and Physiology, 2002
H. Zhai, F. Simion, E. Abrutyn, Almuth M. Koehler, H. Maibach   +4 more
semanticscholar   +1 more source

Antihistamines and their role as antipruritics.

Dermatologic therapy, 2006
Antihistamines that bind to the histamine 1 receptor (H1) serve as important therapeutic agents to counter the effects of histamine in the skin. Two generations of antihistamines exist; however, second-generation agents are more advantageous because they cause less sedation, have a longer half life and are more selective for the H1 receptor.
Michael, O'Donoghue, Michael D, Tharp
openaire   +1 more source

Suppression of Spontaneous Scratching in Hairless Rats by Sedatives but Not by Antipruritics

Skin Pharmacology and Physiology, 2002
J. Thomsen, E. Benfeldt, Jørgen Serup
semanticscholar   +1 more source

DO SYSTEMIC ANTIPRURITIC AGENTS WORK?

British Journal of Dermatology, 1980
‘Most of the agents recommended for the control of itching during the last two decades have not stood the test of time. Many have been discarded, and the continuing use of several of the remaining ones has been dictated not so much by the results obtained as by the desire to prescribe something for the complaining patient.’ Another 20 years have
openaire   +2 more sources

The prevalence and clinical characteristics of pruritus among patients with extensive psoriasis

British Journal of Dermatology, 2000
G. Yosipovitch, A. Goon, J. Wee, Y. Chan, C. Goh   +4 more
semanticscholar   +1 more source

Targeting Itch with Ligands Selective for κ Opioid Receptors.

Handbook of Experimental Pharmacology, 2015
A. Cowan, George B Kehner, S. Inan
semanticscholar   +1 more source

Intrathecal morphine 100 and 200 μg for post-cesarean delivery analgesia: a trade-off between analgesic efficacy and side effects.

International journal of obstetric anesthesia, 2013
J. Y. Wong, Brendan Carvalho, E. T. Riley   +2 more
semanticscholar   +1 more source