Results 131 to 140 of about 263,171 (350)

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Chlorpromazine induced priapism from a single dose: an unusual complication of antipsychotic agent

Russian Open Medical Journal, 2017
Priapism is considered as an unusual andrological emergency that requires urgent intervention. It is defined as prolonged penile erection (usually painful) for more than 4 hours not related to sexual excitation or stimulation.
Mohamed Ahmed Abd El Salam, Hisham Foaad
doaj   +1 more source

Identifying functional network changing patterns in individuals at clinical high-risk for psychosis and patients with early illness schizophrenia: A group ICA study. [PDF]

, 2018
Although individuals at clinical high risk (CHR) for psychosis exhibit a psychosis-risk syndrome involving attenuated forms of the positive symptoms typical of schizophrenia (SZ), it remains unclear whether their resting-state brain intrinsic functional ...
Calhoun, Vince, Chen, Jiayu, Du, Yuhui, Fryer, Susanna, Lin, Dongdong, Loewy, Rachel, Mathalon, Daniel, Stuart, Barbara, Sui, Jing, Yu, Qingbao   +9 more
core   +2 more sources

Advances in Human Mass Balance Studies: An IQ Consortium Perspective on Current Practices and Emerging Trends

Clinical Pharmacology &Therapeutics, EarlyView.
Human radiolabeled mass balance studies are crucial for comprehensively characterizing the absorption, distribution, metabolism, and excretion (ADME) of investigational drugs, providing essential data for drug development, regulatory evaluation, and product labeling.
Jason Boer, Ellen Cannady, Filip Cuyckens, Ulrike Glaenzel, Camille Granvil, Felix Huth, Alexander D. James, Wenying Li, Céline Veau, Graeme Young, Qin Yue, Gregory S. Walker, Upendra A. Argikar, Jonathan N. Bauman, Cathy Cantalloube, Yu‐Luan Chen, Ping Kang, Patricia Moliner, Mette L. Pedersen, Isabel Piel, Simone Schadt, Hanno Schieferstein, Julia Suchomel, Shuai Wang, S. Cyrus Khojasteh   +24 more
wiley   +1 more source

A dopaminergic mechanism of antipsychotic drug efficacy, failure, and failure reversal: the role of the dopamine transporter

Molecular Psychiatry, 2018
Antipsychotic drugs are effective interventions in schizophrenia. However, the efficacy of these agents often decreases over time, which leads to treatment failure and symptom recurrence.
D. Amato, F. Canneva, P. Cumming, S. Maschauer, Dominik Groos, J. Dahlmanns, T. Grömer, L. Chiofalo, Marc Dahlmanns, F. Zheng, J. Kornhuber, O. Prante, C. Alzheimer, S. von Hörsten, C. Müller   +14 more
semanticscholar   +1 more source

Opioid Toxicity Following Concomitant Use of Macrolide Antibiotics with Fentanyl, Hydromorphone, or Oxycodone: A Population‐Based Study

Clinical Pharmacology &Therapeutics, EarlyView.
Fentanyl, hydromorphone, and oxycodone are metabolized by cytochrome P450 3A4 (CYP3A4). Co‐administration with CYP3A4‐inhibiting macrolides (clarithromycin or erythromycin) may increase opioid concentrations and overdose risk, but the clinical impact of these interactions is unknown.
Tony Antoniou, Joanna Yang, David N. Juurlink, Joanne M.‐W. Ho, Muhammad Mamdani, Fangyun Wu, Mina Tadrous, Tara Gomes   +7 more
wiley   +1 more source

Time perception and its neuropsychological correlates in patients with schizophrenia and in healthy volunteers [PDF]

, 2009
Disordered time perception has been reported in schizophrenia. We investigated time perception dysfunction and its neuropsychological correlates in patients with schizophrenia.
Andreasen, Andreasen, Andreasen, Angle, Ashok Mysore, Brandt, Chen, Clegg, Cohen, Davalos, Davalos, Davis, Droit-Volet, Elvevåg, Fioravanti, Franck, Freedman, Gibbon, Gibbon, Gisiger, Goldstone, Heinrichs, Ivry, Kongs, Kwang-Hyuk Lee, Lee, Lee, Lejeune, Lewis, Lewis, Liu, Malapani, Maricq, Maricq, Matell, Meck, Meck, Melges, Nieder, Näätänen, Paul B.L. Birkett, Pearl, Peter W.R. Woodruff, Rabin, Rajinder S. Bhaker, Rammsayer, Randolph W. Parks, Seidman, Sims, Tracy, Tysk, Volz, Wearden, Wearden, Weinstein, Wichmann, Zakay   +56 more
core   +1 more source

Denosumab Offers Relatively Lower Initial Protection Against Osteoporotic Vertebral Fractures in Treatment‐Naive Patients Compared With Zoledronate

Clinical Pharmacology &Therapeutics, EarlyView.
We compared the initial efficacy of denosumab (Dmab) and zoledronate (ZOL) in treatment‐naive patients with osteoporosis. This cohort study, based on TriNetX data, evaluated the risks of fractures and mortality using Kaplan–Meier survival analyses, with hazard ratios (HRs) and 95% confidence intervals (CIs).
Ko‐Hsiu Lu, Shiow‐Ing Wang, Shun‐Fa Yang   +2 more
wiley   +1 more source

Lifetime antipsychotic medication and cognitive performance in schizophrenia at age 43 years in a general population birth cohort

Psychiatry Research, 2017
This naturalistic study analysed the association between cumulative lifetime antipsychotic dose and cognition in schizophrenia after an average of 16.5 years of illness.
A. Husa, J. Moilanen, G. Murray, R. Marttila, M. Haapea, I. Rannikko, J. Barnett, Peter B. Jones, M. Isohanni, A. Remes, H. Koponen, J. Miettunen, E. Jääskeläinen   +12 more
semanticscholar   +1 more source

Drug Critical Limits for Urgent Physician Notification

Clinical Pharmacology &Therapeutics, EarlyView.
Critical limits represent quantitative decision thresholds for drugs that require immediate clinician notification and potential life‐saving intervention. United States hospitals lack a national standard for drug critical limits. We collected critical limits from 417 US hospitals across all 50 states and Washington, D.C.; of these, 411 maintained drug ...
Elina Kuang, Yasmeen Ibrahim, Kyle Cheng, Gerald J. Kost   +3 more
wiley   +1 more source