Antithrombin: Deficiency, Diversity, and the Future of Diagnostics
Mass Spectrometry Reviews, EarlyView.ABSTRACT Our healthcare system provides reactive sick‐care, treating patients after symptoms have appeared by prescription of generic and often suboptimal therapy. This strategy brings along high costs and high pressure which is not sustainable.
Mirjam Kruijt +2 more
wiley +1 more source
Impact of low‐dose quetiapine‐use on glycosylated hemoglobin, triglyceride and cholesterol levels
Acta Psychiatrica Scandinavica, Volume 147, Issue 1, Page 105-116, January 2023., 2023 Abstract Objective Quetiapine use at standard doses has been associated with hyperglycemia and dyslipidemia. However, whether even frequently prescribed low‐dose quetiapine results in significant metabolic disturbances remains unclear. Thus, this study aimed to investigate the association between off‐label, low‐dose quetiapine and changes in ...
Mikkel Højlund +4 more
wiley +1 more source
CardioGenAI: A Machine Learning-Based Framework for Re-Engineering Drugs for Reduced hERG Liability [PDF]
arXivThe link between in vitro hERG ion channel inhibition and subsequent in vivo QT interval prolongation, a critical risk factor for the development of arrythmias such as Torsade de Pointes, is so well established that in vitro hERG activity alone is often sufficient to end the development of an otherwise promising drug candidate.
arxiv
5-Hydroxytryptamine 2A serotonin receptors in the primate cerebral cortex: Possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites [PDF]
, 1998 Robert L. Jakab +1 more
openalex +1 more source
Dynamic Video Assessment of Axial Postural Abnormalities in Parkinson's Disease: A Pilot Study
Movement Disorders Clinical Practice, EarlyView.ABSTRACT Background Axial postural abnormalities (APAs) are frequent and disabling axial symptoms of Parkinson's disease (PD). Image‐based measurement is considered the gold standard but may not accurately detect the true severity of APAs because these symptoms can appear or get worse under dynamic conditions.
Carlo Alberto Artusi +7 more
wiley +1 more source
Neurodevelopment in school‐aged children after intrauterine exposure to antipsychotics
Acta Psychiatrica Scandinavica, Volume 147, Issue 1, Page 43-53, January 2023., 2023 Abstract Objective Antipsychotics are increasingly prescribed in pregnancy, yet little is known about potential long‐term developmental effects on children. In this study, we investigated the effect of prenatal antipsychotic exposure on neurodevelopmental functioning in school‐aged children.
Lisanne Schrijver +8 more
wiley +1 more source
Meta-Analysis of Cytokine Alterations in Schizophrenia: Clinical Status and Antipsychotic Effects
Biological Psychiatry, 2011 B. Miller +4 more
semanticscholar +1 more source
Clozapine-induced potentiation of latent inhibition is due to its action in the conditioning stage: implications for the mechanism of action of antipsychotic drugs [PDF]
, 1999 Eran Shadach, Joram Feldon, Ina Weiner
openalex +1 more source
Prevalence of Parkinson's Disease in 22q11.2 Deletion Syndrome: A Multicenter Study
Movement Disorders Clinical Practice, EarlyView.Abstract Background 22q11.2 deletion syndrome (22q11.2DS) has been associated with increased risk of early‐onset Parkinson's disease (PD). Objective To determine the prevalence and predictors of PD in a large international 22q11.2DS sample. Methods The sample comprised 856 adults (median age 28 (range 16–76) years; 53.0% female).
Emma N.M.M. von Scheibler +13 more
wiley +1 more source