Results 1 to 10 of about 39,176 (275)

Infections associated with clozapine: a pharmacovigilance study using VigiBase®

Frontiers in Pharmacology, 2023
Introduction: Clozapine is primarily reserved for treatment-resistant schizophrenia due to safety concerns associated with its use. Infections have been reported with clozapine, which may lead to elevated serum levels of the drug.
Basile Chrétien, Perrine Brazo, Perrine Brazo, Angélique Da Silva, Marion Sassier, Charles Dolladille, Charles Dolladille, Véronique Lelong-Boulouard, Véronique Lelong-Boulouard, Joachim Alexandre, Joachim Alexandre, Sophie Fedrizzi   +11 more
doaj   +1 more source

An evaluation of the variation and underuse of clozapine in the United Kingdom [PDF]

, 2021
Background Clozapine is the only licensed treatment for treatment refractory schizophrenia. Despite this, it remains grossly underused relative to the prevalence of refractory schizophrenia.
Sukhwinder S. Shergill, Eromona Whiskey, Alex Barnard, Ebenezer Oloyede, David M. Taylor, Olubanke Dzahini   +5 more
core   +1 more source

sj-jpeg-1-tpp-10.1177_20451253211072341 – Supplemental material for Clozapine- and non-clozapine-associated neutropenia in patients with schizophrenia: a retrospective cohort study

, 2022
Supplemental material, sj-jpeg-1-tpp-10.1177_20451253211072341 for Clozapine- and non-clozapine-associated neutropenia in patients with schizophrenia: a retrospective cohort study by Claas-Frederik Johannsen, Tonny Studsgaard Petersen, Jimmi Nielsen ...
Anders Fink-Jensen (724822), Tonny Studsgaard Petersen (7487963), Anders Jørgensen (11724113), Claas-Frederik Johannsen (12200622), Espen Jimenez-Solem (291132), Jimmi Nielsen (6065627)   +5 more
core   +1 more source

Reasons for admission to a general medical hospital for patients taking clozapine

Therapeutic Advances in Psychopharmacology, 2022
Background: Clozapine is associated with a diverse range of side effects. In addition, patients prescribed clozapine commonly suffer with medical comorbidities.
Siobhan Gee, Vasco Almeida, Adam Hughes, Isabel McMullen, David Taylor   +4 more
doaj   +1 more source

Patterns of clozapine use, misuse and disuse in a mental health area in southern Spain

European Psychiatry, 2022
Introduction Evidence supports clozapine as the best treatment in terms of efficacy, effectiveness and well-being, and as the gold standard in treatment-resistant psychotic disorders. Clozapine remains still underused, suffering initiation delays from 1.
L.I. Muñoz-Manchado, J.M. Mongil-Sanjuan, J.M. Pascual Paño, C. Rodríguez-Gómez, R. Torrecilla-Olavarrieta, J.I. Pérez-Revuelta, F. González-Saiz, J.M. Villagrán-Moreno   +7 more
doaj   +1 more source

Clozapine treatment during the COVID-19 pandemic

European Psychiatry, 2021
Introduction Clozapine is an effective antipsychotic used in treatment-resistant schizophrenia. One of the serious complications of clozapine therapy is agranulocytosis, therefore regular monitoring of the level of white blood cells (WBC) in plasma is ...
E. Dąbrowska, B. Galińska-Skok, D. Zalewski, A. Nobis   +3 more
doaj   +1 more source

Clozapine-induced myocarditis in children and adolescents: a pharmacovigilance study using VigiBase and a systematic literature review

, 2023
Clozapine-induced myocarditis in children (age ≤18 yo) was studied from a PubMed search (18 July 2022) (9 cases) and from the World Health Organization’s pharmacovigilance database, called Vigibase, of adverse drug reaction (ADR) reports (72 non ...
Jose de Leon (4242862), Emilio J. Sanz (13780738), Georgios Schoretsanitis (4242865), Manuel Arrojo-Romero (14331944), Carlos De Las Cuevas (13780735), Can-Jun Ruan (10000235)   +5 more
core   +1 more source

Change in plasma concentration of clozapine and norclozapine following a switch of oral formulation

Therapeutic Advances in Psychopharmacology, 2020
Background: Clozapine formulation has been shown to affect plasma concentrations of clozapine and norclozapine. Changes in formulation might result in toxicity or treatment failure.
Farinaz Keshavarzi, Tony Fox, Eromona Whiskey, David Taylor   +3 more
doaj   +1 more source

Factors predicting serum clozapine levels in Middle Eastern patients: an observational study

BMC Psychiatry, 2022
Background Despite its superiority over other drugs for psychosis, clozapine remains underused and is associated with many clinical challenges, including difficulties in predicting therapeutic serum levels (350-600 ng/mL).
Ahmed Hassab Errasoul, Mohammed A. Alarabi   +1 more
doaj   +1 more source

Setting up a clozapine service for Parkinson's psychosis

, 2021
Parkinson's psychosis can be very challenging to manage, with limited treatment options available. There is a good evidence base to support the use of clozapine, but practical obstacles often prevent its use.
Marsh-Davies, Alison, Jackson, Sarah, Skelly, Rob, Archibald, Neil, Taylor, Christine   +4 more
core   +1 more source