Results 11 to 20 of about 62,277 (245)

Effects of Repeated Smoking and Quitting Cigarettes on Plasma Concentrations of Clozapine and Its N-Desmethyl and N-Oxide Metabolites in a Japanese Patient With Schizophrenia. [PDF]

Neuropsychopharmacol Rep
In a Japanese patient with schizophrenia, the effects of repeated smoking and quitting cigarettes on plasma concentrations of clozapine (CLZ) and its major metabolites, N‐desmethyl clozapine (NCLZ) and N‐oxide clozapine (OCLZ), were shown to be reproducible. ABSTRACT Clozapine (CLZ) is used for treatment‐resistant schizophrenia.
Ikawa K, Morikawa N, Sakata M, Horikawa N.   +3 more
europepmc   +2 more sources

Output from VIP cells of the mammalian central clock regulates daily physiological rhythms [PDF]

, 2020
The suprachiasmatic nucleus (SCN) circadian clock is critical for optimising daily cycles in mammalian physiology and behaviour. The roles of the various SCN cell types in communicating timing information to downstream physiological systems remain ...
A Kalsbeek, A Kalsbeek, A Kalsbeek, A Schroeder, AC West, AG Watts, AG Watts, AH Cheng, AJ Harmar, AT Hughes, C Gizowski, C Mazuski, CA Feillet, CS Colwell, DA Bechtold, DF Manvich, DH Loh, DJ Cutler, EE Abrahamson, ES Lein, ES Maywood, FK Stephan, H Taniguchi, H Wakamatsu, HT VanderLeest, HT vanderLeest, I Kallo, IT Lee, J Fahrenkrug, J Fan, J Hannibal, J Schaap, JA Evans, JA Evans, JE Quintero, JL Gomez, JR Jones, JR Jones, K Tanaka, L Hanna, L Madisen, L Mei, LD Alexander, LP Morin, LP Morin, M Howarth, M Mieda, MC Garnica-Siqueira, MJ Krashes, MR Ralph, MS Jasper, N Nunn, N Yamaguchi, P Indic, R Enoki, RL Spencer, RM Buijs, RY Moore, S Itoh, S Paul, SJ Aton, SK Lee, T Ikeno, T Kalamatianos, TJ Nakamura, TM Brown, TM Brown, TM Brown, TM Brown, TO Hermanstyne, WD Todd   +70 more
core   +1 more source

Clozapine generates obsessive compulsive disorder-like behavior in mice

Molecular Brain, 2020
Clozapine is thought to induce obsessive compulsive symptoms (OCS) in schizophrenic patients. However, because OCS are often comorbid with schizophrenia regardless of clozapine treatment, it remains unclear whether clozapine can generate OCS de novo ...
Shinwon Kang, Hyun Jong Noh, Soo Hyeon Bae, Yong-Seok Kim, Hogun Lew, Jisoo Lim, Se Joo Kim, Kyung Sue Hong, Jong-Cheol Rah, Chul Hoon Kim   +9 more
doaj   +1 more source

Clozapine intoxication with severe adverse effects induced by an inflammatory and infectious process: a case report

Journal of Medical Case Reports, 2021
Background Clozapine intoxication can be life-threatening. Outside of the common drug–drug interactions, tobacco smoking, and caffeine consumption, infectious and inflammatory processes are important contributors to clozapine intoxication.
Emmanuel Bebawi, Leila Wakim, Maxime Doré   +2 more
doaj   +1 more source

Clozapine use at a specialised psychiatric hospital in Johannesburg

South African Journal of Psychiatry, 2023
Background: Clozapine is the gold standard medication for treatment-resistant psychosis, with robust evidence supporting its efficacy in multiple symptom domains.
Katherine L. Ord, Belinda Marais
doaj   +1 more source

Tubulin/microtubules as novel clozapine targets

Neuropsychopharmacology Reports, 2022
Aim Clozapine is currently the only effective drug for treatment‐resistant schizophrenia; nonetheless, its pharmacological mechanism remains unclear, and its administration is limited because of severe adverse effects.
Mizuki Hino, Takeshi Kondo, Yasuto Kunii, Junya Matsumoto, Akira Wada, Shin‐ichi Niwa, Mitsutoshi Setou, Hirooki Yabe   +7 more
doaj   +1 more source

Clozapine as add-on medication in the maintenance treatment of bipolar and schizoaffective disorders - A case series [PDF]

, 2002
Atypical neuroleptics are increasingly used in the treatment of bipolar and schizoaffective disorders. Currently, numerous controlled short-term studies are available for clozapine, olanzapine, risperidone or quetiapine, but long-term data are still ...
Amann, B., Dittmann, Sandra, Forsthoff, A., Grunze, Heinz, Hummel, B., Matzner, N.   +5 more
core   +1 more source

Sex differences in plasma clozapine and norclozapine concentrations in clinical practice and in relation to body mass index and plasma glucose concentrations: a retrospective survey [PDF]

, 2015
Background Clozapine is widely prescribed and, although effective, can cause weight gain and dysglycemia. The dysmetabolic effects of clozapine are thought to be more prevalent in women with this gender on average attaining 17 % higher plasma clozapine ...
Anderson, Simon G., Connolly, Moira, Couchman, Lewis, Flanagan, Robert J., Heald, A. H., Livingston, Mark, Miller, Joan, Smith, Daniel J.   +7 more
core   +2 more sources

Cannabis and schizophrenia [PDF]

, 2014
BACKGROUND Schizophrenia is a mental illness causing disordered beliefs, ideas and sensations. Many people with schizophrenia smoke cannabis, and it is unclear why a large proportion do so and if the effects are harmful or beneficial. It is also unclear
Gillies, Donna, Kalakouti, Eliana, Kyprianou, Katerina, McLoughlin, Benjamin C., Pushpa-Rajah, Jonathan A., Rathbone, John, Variend, Hannele   +6 more
core   +1 more source

Atypical antipsychotic therapy in Parkinson's disease psychosis: A retrospective study. [PDF]

, 2017
ObjectiveParkinson's disease psychosis (PDP) is a frequent complication of idiopathic Parkinson's disease (iPD) with significant impact on quality of life and association with poorer outcomes.
Bizzarri, Cummings, Fernandez, Fernandez, Fénelon, Gama, Goldman, Hack, Hubbard, Kiferle, Lertxundi, McFarland, Meltzer, Meral, Mesquita, Mocci, Munhoz, Noel, Pagonabarraga, Prohorov, Rabey, Reichmann, Rolland, Seppi, Shotbolt, Starkstein, Thomas, Vanover, Weintraub, Zhu   +29 more
core   +2 more sources