Results 11 to 20 of about 29,714 (222)
Clozapine use at a specialised psychiatric hospital in Johannesburg
South African Journal of Psychiatry, 2023 Background: Clozapine is the gold standard medication for treatment-resistant psychosis, with robust evidence supporting its efficacy in multiple symptom domains.
Katherine L. Ord, Belinda Marais
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Clozapine generates obsessive compulsive disorder-like behavior in mice
Molecular Brain, 2020 Clozapine is thought to induce obsessive compulsive symptoms (OCS) in schizophrenic patients. However, because OCS are often comorbid with schizophrenia regardless of clozapine treatment, it remains unclear whether clozapine can generate OCS de novo ...
Shinwon Kang +9 more
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Journal of Medical Case Reports, 2021 Background Clozapine intoxication can be life-threatening. Outside of the common drug–drug interactions, tobacco smoking, and caffeine consumption, infectious and inflammatory processes are important contributors to clozapine intoxication.
Emmanuel Bebawi +2 more
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Tubulin/microtubules as novel clozapine targets
Neuropsychopharmacology Reports, 2022 Aim Clozapine is currently the only effective drug for treatment‐resistant schizophrenia; nonetheless, its pharmacological mechanism remains unclear, and its administration is limited because of severe adverse effects.
Mizuki Hino +7 more
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BMC Psychiatry, 2022 Background Clozapine has the greatest efficacy for treatment-resistant schizophrenia (TRS), even though its underutilization is not uncommon across different countries.
Leeba Rezaie +4 more
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Infections associated with clozapine: a pharmacovigilance study using VigiBase®
Frontiers in Pharmacology, 2023 Introduction: Clozapine is primarily reserved for treatment-resistant schizophrenia due to safety concerns associated with its use. Infections have been reported with clozapine, which may lead to elevated serum levels of the drug.
Basile Chrétien +11 more
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Reasons for admission to a general medical hospital for patients taking clozapine
Therapeutic Advances in Psychopharmacology, 2022 Background: Clozapine is associated with a diverse range of side effects. In addition, patients prescribed clozapine commonly suffer with medical comorbidities.
Siobhan Gee +4 more
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Patterns of clozapine use, misuse and disuse in a mental health area in southern Spain
European Psychiatry, 2022 Introduction Evidence supports clozapine as the best treatment in terms of efficacy, effectiveness and well-being, and as the gold standard in treatment-resistant psychotic disorders. Clozapine remains still underused, suffering initiation delays from 1.
L.I. Muñoz-Manchado +7 more
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Clozapine treatment during the COVID-19 pandemic
European Psychiatry, 2021 Introduction Clozapine is an effective antipsychotic used in treatment-resistant schizophrenia. One of the serious complications of clozapine therapy is agranulocytosis, therefore regular monitoring of the level of white blood cells (WBC) in plasma is ...
E. Dąbrowska +3 more
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Change in plasma concentration of clozapine and norclozapine following a switch of oral formulation
Therapeutic Advances in Psychopharmacology, 2020 Background: Clozapine formulation has been shown to affect plasma concentrations of clozapine and norclozapine. Changes in formulation might result in toxicity or treatment failure.
Farinaz Keshavarzi +3 more
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