Results 21 to 30 of about 39,176 (275)
Clozapine prescribing during follow-up of a first-episode psychosis cohort
European Psychiatry, 2021 Introduction Of those with schizophrenia, one third develop treatment-resistant illness. Nearly 60% of these benefit from clozapine- the only antipsychotic medication licensed in this group.
R. Rowntree +7 more
doaj +1 more source
Successful clozapine rechallenge after neutropenia using lithium carbonate : a case report
European Psychiatry, 2022 Introduction Clozapine is widely known as the drug of choice in treating refractory schizophrenia. However, clozapine prescription requires close clinical and biological monitoring to prevent harmful side effects like agranulocytosis, neutropenia and ...
D. Khattech +5 more
doaj +1 more source
Clozapine generates obsessive compulsive disorder-like behavior in mice
Molecular Brain, 2020 Clozapine is thought to induce obsessive compulsive symptoms (OCS) in schizophrenic patients. However, because OCS are often comorbid with schizophrenia regardless of clozapine treatment, it remains unclear whether clozapine can generate OCS de novo ...
Shinwon Kang +9 more
doaj +1 more source
Clozapine use at a specialised psychiatric hospital in Johannesburg
South African Journal of Psychiatry, 2023 Background: Clozapine is the gold standard medication for treatment-resistant psychosis, with robust evidence supporting its efficacy in multiple symptom domains.
Katherine L. Ord, Belinda Marais
doaj +1 more source
Clozapine as add-on medication in the maintenance treatment of bipolar and schizoaffective disorders - A case series [PDF]
, 2002 Atypical neuroleptics are increasingly used in the treatment of bipolar and schizoaffective disorders. Currently, numerous controlled short-term studies are available for clozapine, olanzapine, risperidone or quetiapine, but long-term data are still ...
Hummel, B. +5 more
core +1 more source
Identification of a domain which affects kinetics and antagonistic potency of clozapine at 5-HT3 receptors. [PDF]
, 2009 The widely used atypical antipsychotic clozapine is a potent competitive antagonist at 5-HT(3) receptors which may contribute to its unique psychopharmacological profile. Clozapine binds to 5-HT(3) receptors of various species.
Gerhard Rammes +27 more
core +1 more source
Journal of Medical Case Reports, 2021 Background Clozapine intoxication can be life-threatening. Outside of the common drug–drug interactions, tobacco smoking, and caffeine consumption, infectious and inflammatory processes are important contributors to clozapine intoxication.
Emmanuel Bebawi +2 more
doaj +1 more source
How Non-Medical Prescribing may Impact on the Service Development of a Clozapine Clinic [PDF]
, 2009 The purpose of this article is to discuss the possible implications of applying non medical prescribing practices to a Clozapine clinic in the Rotherham, Doncaster and South Humber Mental Health NHS Foundation Trust (RDASH). To reflect on such issues the
Woolhouse, Nicola
core +1 more source
Tubulin/microtubules as novel clozapine targets
Neuropsychopharmacology Reports, 2022 Aim Clozapine is currently the only effective drug for treatment‐resistant schizophrenia; nonetheless, its pharmacological mechanism remains unclear, and its administration is limited because of severe adverse effects.
Mizuki Hino +7 more
doaj +1 more source
BMC Psychiatry, 2022 Background Clozapine has the greatest efficacy for treatment-resistant schizophrenia (TRS), even though its underutilization is not uncommon across different countries.
Leeba Rezaie +4 more
doaj +1 more source