Results 31 to 40 of about 39,176 (275)

Clozapine-induced diarrhea: A case report and mechanistic overview. [PDF]

PCN Rep
Abstract Background Clozapine is an atypical antipsychotic that is highly effective in managing treatment‐resistant schizophrenia. However, its use is associated with a wide range of adverse effects, including agranulocytosis, seizures, sedation, and gastrointestinal issues such as constipation, and less commonly, diarrhea. While constipation is a well‐
Dastmardi S, Namazi S.
europepmc   +2 more sources

Effects of Repeated Smoking and Quitting Cigarettes on Plasma Concentrations of Clozapine and Its N-Desmethyl and N-Oxide Metabolites in a Japanese Patient With Schizophrenia. [PDF]

Neuropsychopharmacol Rep
In a Japanese patient with schizophrenia, the effects of repeated smoking and quitting cigarettes on plasma concentrations of clozapine (CLZ) and its major metabolites, N‐desmethyl clozapine (NCLZ) and N‐oxide clozapine (OCLZ), were shown to be reproducible. ABSTRACT Clozapine (CLZ) is used for treatment‐resistant schizophrenia.
Ikawa K, Morikawa N, Sakata M, Horikawa N.   +3 more
europepmc   +2 more sources

Relaxation of Japan's clozapine monitoring system is urgently needed: Adding 10,000 future prescriptions may prevent up to 400 schizophrenia-related suicides and cost 1 death by agranulocytosis. [PDF]

PCN Rep
Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 2, June 2026.
de Leon J, Kikuchi Y, Yasui-Furukori N.
europepmc   +2 more sources

Clozapine—balancing the body and the mind

, 2022
In this issue of The Lancet Psychiatry , Jari Tiihonen and colleagues 1 have investigated the slightly increased risk of rare haematological malignancies associated with long-term use of clozapine. This important finding needs to be contextualised to the
Nick Myles, Myles, N, Siskind, D, Kisely, S, Dan Siskind, Steve Kisely   +5 more
core   +1 more source

Relaxation of the criteria for entry to the UK Clozapine Central Non-Rechallenge Database: a modelling study [PDF]

, 2022
Background Clozapine is uniquely effective in treatment-resistant psychosis. In the UK, patients must discontinue clozapine indefinitely if they are placed on the Central Non-Rechallenge Database (CNRD) after their haematological parameters fall below ...
Prof Fiona Gaughran, Eromona Whiskey, Ebenezer Oloyede, Cecilia Casetta, Danielle Dunnett, Prof Sukhi Shergill, Prof David Taylor, Prof James H MacCabe, Olubanke Dzahini, Shreyans Gandhi, Prof Philip McGuire   +10 more
core   +1 more source

Clozapine-Induced Myocarditis and Pericarditis

, 2016
Objective: Clozapine is known to cause cardiac side-effects, including myocarditis, pericarditis and cardiomyopathy. A 50-year-old Malay man with schizoaffective disorder and tardive dyskinesia who developed transient tachycardia, low blood pressure ...
Nurul Nadia Ismail (2892086), Fazil Ahmad (2892083), Zahiruddin Othman (2887667), Ahmad Shahril Abdul Halim (2892080)   +3 more
core   +1 more source

Potential Indicators of Bone Marrow Suppression in Patients with Schizophrenia Receiving Clozapine: Platelet-Large Cell Ratio and Immature Granulocytes

Psychiatry and Behavioral Sciences
Aim/background: The use of clozapine is restricted due to its serious side effects, particularly bone marrow suppression, which occurs at an average rate of 1%.
Hatice Saracoğlu, Ciğdem Karakukcu, Canan Kılıc, Yasemin Şimşek   +3 more
doaj   +1 more source

A case of hypotension and heart rate changes on rechallenge with a low dose of clozapine with no apparent secondary cause

Sri Lanka Journal of Psychiatry, 2022
Clozapine is known to cause innocuous as well as severe and or fatal cardiovascular side effects. These side effects are commonly reported at the initiation of clozapine therapy.
M. L. Harshini, A. I. W. Fernando, H. M. T. S. Abayawickrama, M. I. N. Ikram, S. Rajapakse, A. Hapangama   +5 more
doaj   +1 more source

Weight Gain with Clozapine: 8-Year Cohort Naturalistic Study among Hospitalized Chinese Schizophrenia Patients

, 2011
Objective: Clozapine is associated with significant weight gain. However, it is still debatable whether the majority of weight gain occurs in the early phase of treatment or if weight gain is a persistent side effect. The inconsistent results in previous
BAI, YA-MEI;CHEN, JEN-YEU;CHEN, TZU-TING;LIN, CHIH-YUAN;CHOU, PESUS;SU, TUNG-PING;LIN, CHAO-CHENG, 白雅美;陳震宇;陳姿婷;林知遠;周碧瑟;蘇東平;林朝誠   +1 more
core   +1 more source

Fibronectin1‐Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition

Advanced Science, EarlyView.
Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei, Jiaying Shi, Jing Xi, Yixiang Xu, Shuye Ying, Xukun Fan, Wangjialu Lu, Zhisheng Li, Menghan Li, Yu Wang, Li Cheng, Lin Yang, Lingyu Xu, Zhong Chen, Cenglin Xu, Yi Wang   +15 more
wiley   +1 more source