Results 41 to 50 of about 45,210 (266)

Weight Gain with Clozapine: 8-Year Cohort Naturalistic Study among Hospitalized Chinese Schizophrenia Patients

, 2011
Objective: Clozapine is associated with significant weight gain. However, it is still debatable whether the majority of weight gain occurs in the early phase of treatment or if weight gain is a persistent side effect. The inconsistent results in previous
BAI, YA-MEI;CHEN, JEN-YEU;CHEN, TZU-TING;LIN, CHIH-YUAN;CHOU, PESUS;SU, TUNG-PING;LIN, CHAO-CHENG, 白雅美;陳震宇;陳姿婷;林知遠;周碧瑟;蘇東平;林朝誠   +1 more
core   +1 more source

A case of hypotension and heart rate changes on rechallenge with a low dose of clozapine with no apparent secondary cause

Sri Lanka Journal of Psychiatry, 2022
Clozapine is known to cause innocuous as well as severe and or fatal cardiovascular side effects. These side effects are commonly reported at the initiation of clozapine therapy.
M. L. Harshini, A. I. W. Fernando, H. M. T. S. Abayawickrama, M. I. N. Ikram, S. Rajapakse, A. Hapangama   +5 more
doaj   +1 more source

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source

Pathologic Changes in the Liver During Acute Exposure to Clozapine and Its Combination with Ethanol (Experimental Study)

Общая реаниматология, 2019
Purpose: identification of pathological changes in the liver at early stages of the effect of clozapine and clozapine combined with ethanol to improve the diagnosis of this acute exposure.Materials and methods. The experiments were carried out on outbred
O. L. Romanova, D. V. Sudukov, M. A. Golubev, M. L. Blagonravov, V. V. Goshkoev, A. A. Churilov   +5 more
doaj   +1 more source

Treatment-resistant schizophrenia : the relationship between clozapine plasma concentration and clinical outcome

European Psychiatry, 2022
Introduction Clozapine is highly effective in patients with treatment-resistant schizophrenia but, to ensure optimal clinical response it is important to optimize its use and this depends on adequate pharmacological monitoring.
I. Kammoun, R. Jouini, A. Aissa, R. Boukhchina, Y. Zgueb, E. Khelifa, U. Ouali, R. Jomli, F. Nacef, Z. El Hechmi   +9 more
doaj   +1 more source

Setting up a clozapine service for Parkinson's psychosis

, 2021
Parkinson's psychosis can be very challenging to manage, with limited treatment options available. There is a good evidence base to support the use of clozapine, but practical obstacles often prevent its use.
Marsh-Davies, Alison, Jackson, Sarah, Skelly, Rob, Archibald, Neil, Taylor, Christine   +4 more
core   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Influence of pharmacokinetics‐related gene polymorphisms on plasma levels of clozapine and its metabolites in Japanese patients with schizophrenia

PCN Reports
Aim Clozapine is an atypical antipsychotic drug that is most effective against treatment‐resistant schizophrenia and causes serious adverse effects, including agranulocytosis. We examined the relationships between age, sex, genetic polymorphisms, and the
Shinya Kinoshita, Hideyuki Motohashi, Keiichiro Nishida, Seiichiro Tarutani, Tetsufumi Kanazawa, Junya Nagai   +5 more
doaj   +1 more source

Rapid Dose-Dependent Effect of Clozapine on a Schizophrenic Patient's Lipid Profile

, 2011
Clozapine is known to be associated with higher risk of metabolic syndrome, including dyslipidaemia, but the mechanisms of such a relationship are still under debate.
江惠綾;劉震鐘;黃宗正, CHIANG, HUEY-LING;LIU, CHEN-CHUNG;HWANG, TZUNG- JENG   +1 more
core   +1 more source

CLOZAPINE AND HALOPERIDOL INCREASE THE EXPRESSION OF PED/PEA-15: A PUTATIVE NOVEL MECHANISM FOR ANTIPSYCHOTIC-RELATED DIABETES [PDF]

, 2008
Schizophrenia is a serious disorder that affects 1% of the population in the United States and Europe, and is associated with a significant reduction in life expectancy that approaches 20% compared with that of the general population.
Panariello, Fabio
core   +1 more source