Results 51 to 60 of about 62,277 (245)

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source

The effect of clozapine on prolactin secretion at the level of the lactotroph [PDF]

, 1990
Clozapine is an antipsychotic drug which is unusual in that it has no dopamine receptor-blocking activity. Previous studies gave conflicting results whether administration of clozapine induces hyperprolactinemia.
Hofland, L.J. (Leo), Koetsveld, P.M. (Peter) van, Lamberts, S.W.J. (Steven)   +2 more
core   +1 more source

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

Advanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian, Xiao‐Long Wang, Li Yin, Wei Wei, Xue Li, Yao Ge, Zhao‐Xia Xiang, Na Tian, Li‐Juan Chen, Ming‐Wei Ma, Xia Zhang, Xu Jing, Mei‐Yun Wang, Xu‐Feng Xu   +13 more
wiley   +1 more source

Pathologic Changes in the Liver During Acute Exposure to Clozapine and Its Combination with Ethanol (Experimental Study)

Общая реаниматология, 2019
Purpose: identification of pathological changes in the liver at early stages of the effect of clozapine and clozapine combined with ethanol to improve the diagnosis of this acute exposure.Materials and methods. The experiments were carried out on outbred
O. L. Romanova, D. V. Sudukov, M. A. Golubev, M. L. Blagonravov, V. V. Goshkoev, A. A. Churilov   +5 more
doaj   +1 more source

Treatment-resistant schizophrenia : the relationship between clozapine plasma concentration and clinical outcome

European Psychiatry, 2022
Introduction Clozapine is highly effective in patients with treatment-resistant schizophrenia but, to ensure optimal clinical response it is important to optimize its use and this depends on adequate pharmacological monitoring.
I. Kammoun, R. Jouini, A. Aissa, R. Boukhchina, Y. Zgueb, E. Khelifa, U. Ouali, R. Jomli, F. Nacef, Z. El Hechmi   +9 more
doaj   +1 more source

Flavin-containing monooxygenases: mutations, disease and drug response [PDF]

, 2008
NOTICE: this is the author’s version of a work that was accepted for publication in Trends in Pharmacological Sciences. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality ...
Phillips, IR, Shephard, EA
core   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Influence of pharmacokinetics‐related gene polymorphisms on plasma levels of clozapine and its metabolites in Japanese patients with schizophrenia

PCN Reports
Aim Clozapine is an atypical antipsychotic drug that is most effective against treatment‐resistant schizophrenia and causes serious adverse effects, including agranulocytosis. We examined the relationships between age, sex, genetic polymorphisms, and the
Shinya Kinoshita, Hideyuki Motohashi, Keiichiro Nishida, Seiichiro Tarutani, Tetsufumi Kanazawa, Junya Nagai   +5 more
doaj   +1 more source

Clozapine Withdrawal Catatonia: A Case Series and Review of Literature

Annals of Indian Psychiatry
Background: Catatonia has been reported with withdrawal of medications. Among the various psychotropics, clozapine has been implicated to cause catatonia when abruptly withdrawn. The data regarding clozapine withdrawal catatonia are scarce and are mostly
Gopika Jagota, Sandeep Grover
doaj   +1 more source

Genetic association analysis of N-methyl-d-aspartate receptor subunit gene GRIN2B and clinical response to clozapine [PDF]

, 2016
OBJECTIVE: Approximately 30% of patients with schizophrenia fail to respond to antipsychotic therapy and are classified as having treatment-resistant schizophrenia.
Abrams, Alonso, Altar, American Psychiatric Association, American Psychiatric Association, American Psychiatric Association, Anson, Arvanov, Asztely, Ayalew, Banerjee, Barrett, Bertilsson, Black, Bleehen, Borgio, Brown, Buka, Cai, Centorrino, Chiu, Corbett, Cosgrove, Creese, Daly, Davis, Di Maria, Dorval, Dudbridge, Elkis, Emsley, Endele, Evins, Fitzgerald, Freed, Galderisi, Gauderman, Gauderman, Ghassabian, Giardino, Gomes, Gunduz-Bruce, Hagg, Hardy, Harrow, Heresco-Levy, Heresco-Levy, Hirai, Hong, Hopkins, Horacek, Hosking, Hoyer, Hwang, Javitt, Jia, Kane, Kargieman, Kay, Kay, Kennedy, Kharazia, Kohlrausch, Komuro, Kubota, Kumra, Kuryatov, Lacro, Lahiri, Lahti, Laube, Lieberman, Lindenmayer, Linn, Liu, Long, Luby, Luisada, Malhotra, Mandich, Manolio, Massey, Mata, Mayer, McAdams, McGlashan, Meltzer, Meltzer, Meshul, Miyamoto, Mortensen, Mortimer, Newman-Tancredi, Ninan, Noda, Nowak, Nyholt, Odom-White, Ossowska, Overall, Overall, Palego, Park, Paschou, Patil, Pearce, Perkins, Pickar, Pilowsky, Pinard, Price, Purcell, Purkayastha, Sadee, Sadee, Sasieni, Schiller, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Schmitt, Schotte, Seeman, Seppala, Shapiro, Solanki, St Clair, Sun, Susser, Szczepankiewicz, Tandon, Theisen, Tian, Tingley, VanLiere, Ventura, Vojvoda, Weinberg, Wittke-Thompson, Wyatt, Xia, Xu, Yamamoto, Yoo, Zhang, Zhao, Zuk   +144 more
core   +1 more source