Results 241 to 250 of about 3,364,808 (342)

A Clinical Medication Review Focused on Deprescribing in Older Patients With Hyperpolypharmacy: A Mixed‐Methods Feasibility Study

open access: yesBasic &Clinical Pharmacology &Toxicology, Volume 138, Issue 2, February 2026.
ABSTRACT To address challenges in deprescribing, we investigated the feasibility of an intervention consisting of a clinical medication review (CMR) focused on deprescribing, supported by a training programme for healthcare providers (HCPs) among older patients with hyperpolypharmacy (≥ 10 chronic medications) in primary care.
Gert Baas   +6 more
wiley   +1 more source

Advancing the measurement of psychotherapy outcomes for youth with irritability using in vivo ecological momentary assessment: an exploratory observational study

open access: yesChild and Adolescent Mental Health, Volume 31, Issue 1, Page 33-40, February 2026.
Background Ecological momentary assessment (EMA) can reveal naturalistic within‐person changes in symptoms and behaviors, essential for examining psychotherapy's effectiveness. However, no prior study has leveraged EMA to assess real‐time, naturalistic changes of clinical symptoms during psychotherapy in youth with clinically impairing irritability ...
Reut Naim   +6 more
wiley   +1 more source

Six‐Year Trends in Real‐World Data Use for Post‐Marketing Surveillance of New Medical Products in Japan

open access: yesClinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT The Ministerial Ordinance on Good Post‐Marketing Study Practice for Drugs was amended by the Ministry of Health, Labour and Welfare (MHLW) in 2018 to clearly define post‐marketing database studies (DBS) as a measure of pharmacovigilance activities for approved medical products in Japan.
Suguru Okami   +2 more
wiley   +1 more source

Modeling cerebral palsy in animals

open access: yesDevelopmental Medicine &Child Neurology, Volume 68, Issue 2, Page 158-174, February 2026.
Abstract Advancements in the treatment of cerebral palsy depend on animal research. Yet, most animal models have not been fully evaluated for spasticity and dystonia using clinically relevant measures of altered tone or movement patterns, which form the basis for diagnosing people with the condition.
Katharina A. Quinlan   +8 more
wiley   +1 more source

Comparative effectiveness of sodium‐glucose cotransporter‐2 inhibitors and glucagon‐like peptide‐1 receptor agonists for incident dementia: A retrospective multicohort study

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 1443-1452, February 2026.
Abstract Objective This study provides real‐world evidence on the comparative effectiveness of glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) regarding the risk of incident dementia in adults with type 2 diabetes mellitus (T2DM).
Filippos Anagnostakis   +4 more
wiley   +1 more source

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