Results 1 to 10 of about 169,486 (196)

Effects of Risperidone and Prenatal Poly I:C Exposure on GABA_A Receptors and AKT-GSK3β Pathway in the Ventral Tegmental Area of Female Juvenile Rats

Biomolecules, 2022
The ventral tegmental area (VTA) in the ventral midbrain is the origin of the dopaminergic neurotransmission pathways. Although GABAA receptors and AKT-GSK3β signaling are involved in the pathophysiology of mental disorders and are modulated by ...
Shiyan Chen, Jiamei Lian, Yueqing Su, Chao Deng   +3 more
doaj   +1 more source

Epigenetic histone acetylation modulating prenatal Poly I:C induced neuroinflammation in the prefrontal cortex of rats: a study in a maternal immune activation model

Frontiers in Cellular Neuroscience, 2022
Introduction: Neuroinflammation in the central nervous system, particularly the prefrontal cortex (PFC), plays a role in the pathogenesis of schizophrenia, which has been found to be associated with maternal immune activation (MIA).
Yueqing Su, Yueqing Su, Yueqing Su, Yueqing Su, Jiamei Lian, Jiamei Lian, Shiyan Chen, Wenchang Zhang, Chao Deng, Chao Deng   +9 more
doaj   +1 more source

Seventy Years of Antipsychotic Development: A Critical Review

Biomedicines, 2023
Since the mid-1950s discovery of the first effective antipsychotic medications (APM), we have only been able to improve the tolerability but not the overall efficacy of currently available APMs, as reflected by effectiveness trials in Europe and the ...
Mujeeb U. Shad
doaj   +1 more source

Lipidomics Reveals Early Metabolic Changes in Subjects with Schizophrenia: Effects of Atypical Antipsychotics [PDF]

, 2013
There is a critical need for mapping early metabolic changes in schizophrenia to capture failures in regulation of biochemical pathways and networks.
AA Farooqui, AI Glen, BE Leonard, C Luo, D Cohen, DF Horrobin, DF Horrobin, DP Rice, George G. Dougherty, GP Amminger, Henry A. Nasrallah, HM Rhoades, Hongjie Zhu, Jeffrey K. Yao, JJ Potwarka, JK Yao, JK Yao, JM Kane, Joseph McEvoy, JP McEvoy, JR Hibbeln, K Ohara, KS Dervola, M Arvindakshan, M McSweeney, M Peet, M Strassnig, M Zeman, Matcheri S. Keshavan, MK Gregory, MS Keshavan, MS Keshavan, MS Keshavan, Peter Buckley, R Kaddurah-Daouk, R Kaddurah-Daouk, RA Johnson, RD McQuade, Rebecca A. Baillie, Rima Kaddurah-Daouk, S Mukherjee, S Saddichha, S Sengupta, SH Fatemi, SJ Wood, SM Watkins, SM Watkins, SP Mahadik, T Sumiyoshi, Takeo Yoshikawa, TJ Barrett, TM du Bois, WJ van der Kemp, WP Hoen, Y Benjamini, Y Benjamini, YA Hannun   +56 more
core   +11 more sources

Comparison of Haloperidol and Quetiapine for Treatment of Delirium in Critical Illness: A Prospective Randomised Double-blind Placebo-controlled Trial [PDF]

Journal of Clinical and Diagnostic Research, 2022
Introduction: Delirium is associated with an increased chance of death, prolonged hospitalisation, higher healthcare costs, and possibly long-term brain damage in survivors.
Rishabah Garg, Vipin Kumar Singh, Pratishruti, GP Singh   +3 more
doaj   +1 more source

Analgesic Effects of Oxycodone in Combination With Risperidone or Ziprasidone: Results From a Pilot Randomized Controlled Trial in Healthy Volunteers

Frontiers in Pain Research, 2022
Background and ObjectivesPatients taking opioids are at risk of developing dependence and possibly abuse. Given the role of the mesolimbic dopamine system in opioid reward, blocking dopamine D2 receptors should limit the abuse liability of opioid ...
Ameet S. Nagpal, Daniel J. Lodge, Jennifer S. Potter, Alan Frazer, Robin Tragus, Megan E. Curtis, Megan E. Curtis, Angela M. Boley, Maxim Eckmann   +8 more
doaj   +1 more source

Maintenance Therapy of Psychosis Spectrum Disorders in a Real-World Setting: Antipsychotics Prescription Patterns and Long-Term Benzodiazepine Use

Frontiers in Psychiatry, 2022
BackgroundMaintenance therapy of patients with primary psychosis spectrum disorders (PSD) in the Western Balkans has received limited interest so far.
Nadja P. Maric, Sanja Andric Petrovic, Manuela Russo, Stefan Jerotic, Ivan Ristic, Bojana Savić, Tamara Pemovska, Milos Milutinovic, Emina Ribic, Silvana Markovska-Simoska, Alma Dzubur Kulenovic, Nikolina Jovanovic   +11 more
doaj   +1 more source

Antipsychotic Polypharmacy

Focus, 2020
Physicians who treat patients with schizophrenia frequently encounter complex clinical situations not fully addressed by published treatment guidelines. Some of these situations lead to antipsychotic polypharmacy, often prescribed when clinical and social obstacles prevent access to clozapine and patients have had suboptimal responses to nonclozapine ...
Adriana, Foster, Jordanne, King
openaire   +3 more sources

Altered brainstem responses to modafinil in schizophrenia: implications for adjunctive treatment of cognition. [PDF]

, 2018
Candidate pro-cognitive drugs for schizophrenia targeting several neurochemical systems have consistently failed to demonstrate robust efficacy. It remains untested whether concurrent antipsychotic medications exert pharmacodynamic interactions that ...
Carter, Cameron S, Minzenberg, Michael J, Soosman, Steffan K, Yoon, Jong H   +3 more
core   +3 more sources

Cannabis and schizophrenia [PDF]

, 2014
BACKGROUND Schizophrenia is a mental illness causing disordered beliefs, ideas and sensations. Many people with schizophrenia smoke cannabis, and it is unclear why a large proportion do so and if the effects are harmful or beneficial. It is also unclear
Gillies, Donna, Kalakouti, Eliana, Kyprianou, Katerina, McLoughlin, Benjamin C., Pushpa-Rajah, Jonathan A., Rathbone, John, Variend, Hannele   +6 more
core   +1 more source