Results 1 to 10 of about 41,988 (210)

Effects of Risperidone and Prenatal Poly I:C Exposure on GABA_A Receptors and AKT-GSK3β Pathway in the Ventral Tegmental Area of Female Juvenile Rats

Biomolecules, 2022
The ventral tegmental area (VTA) in the ventral midbrain is the origin of the dopaminergic neurotransmission pathways. Although GABAA receptors and AKT-GSK3β signaling are involved in the pathophysiology of mental disorders and are modulated by ...
Shiyan Chen, Jiamei Lian, Yueqing Su, Chao Deng   +3 more
doaj   +1 more source

Epigenetic histone acetylation modulating prenatal Poly I:C induced neuroinflammation in the prefrontal cortex of rats: a study in a maternal immune activation model

Frontiers in Cellular Neuroscience, 2022
Introduction: Neuroinflammation in the central nervous system, particularly the prefrontal cortex (PFC), plays a role in the pathogenesis of schizophrenia, which has been found to be associated with maternal immune activation (MIA).
Yueqing Su, Yueqing Su, Yueqing Su, Yueqing Su, Jiamei Lian, Jiamei Lian, Shiyan Chen, Wenchang Zhang, Chao Deng, Chao Deng   +9 more
doaj   +1 more source

Can authorities appreciably enhance the prescribing of oral generic risperidone to conserve resources? : findings from across Europe and their implications [PDF]

, 2014
Generic atypical antipsychotic drugs offer health authorities opportunities for considerable savings. However, schizophrenia and bipolar disorders are complex diseases that require tailored treatments.
Barbui, Corrado, Petzold, Max, Piessnegger, Jutta, Simoens, Steven, Finlayson, Alexander E, Zara, Corinne, Persson, Marie, Godman, Brian, Bennie, Marion, Raschi, Emanuel, Bucsics, Anna, Martin, Andrew, Bennett, Kathleen   +12 more
core   +5 more sources

Seventy Years of Antipsychotic Development: A Critical Review

Biomedicines, 2023
Since the mid-1950s discovery of the first effective antipsychotic medications (APM), we have only been able to improve the tolerability but not the overall efficacy of currently available APMs, as reflected by effectiveness trials in Europe and the ...
Mujeeb U. Shad
doaj   +1 more source

Comparison of Haloperidol and Quetiapine for Treatment of Delirium in Critical Illness: A Prospective Randomised Double-blind Placebo-controlled Trial [PDF]

Journal of Clinical and Diagnostic Research, 2022
Introduction: Delirium is associated with an increased chance of death, prolonged hospitalisation, higher healthcare costs, and possibly long-term brain damage in survivors.
Rishabah Garg, Vipin Kumar Singh, Pratishruti, GP Singh   +3 more
doaj   +1 more source

Antipsychotic Response in the First Week Predicts Later Efficacy [PDF]

, 2012
Background and Aims: Time of onset of antipsychotic action is still a debated matter. We aimed to replicate and extend previous findings that early response can predict subsequent non-response.
Andrisano, Costanza, Porcelli, Stefano, Serretti, Alessandro, Balzarro, Beatrice, Möller, Hans-Jürgen, Rujescu, Dan, Giegling, Ina, Schäfer, Martin   +7 more
core   +2 more sources

Analgesic Effects of Oxycodone in Combination With Risperidone or Ziprasidone: Results From a Pilot Randomized Controlled Trial in Healthy Volunteers

Frontiers in Pain Research, 2022
Background and ObjectivesPatients taking opioids are at risk of developing dependence and possibly abuse. Given the role of the mesolimbic dopamine system in opioid reward, blocking dopamine D2 receptors should limit the abuse liability of opioid ...
Ameet S. Nagpal, Daniel J. Lodge, Jennifer S. Potter, Alan Frazer, Robin Tragus, Megan E. Curtis, Megan E. Curtis, Angela M. Boley, Maxim Eckmann   +8 more
doaj   +1 more source

Administering LAAIs: an education and training workshop [PDF]

, 2013
This is the second of two articles that focus on the inter-collaborative work, between education and practice, to enhance theoretical and practical delivery for mental health nurses when administrating long-acting antipsychotic injections (LAAIs).
Covill, Carl, Hemingway, Steve, Stephenson, John, Holliday, Lindsay   +3 more
core   +4 more sources

Maintenance Therapy of Psychosis Spectrum Disorders in a Real-World Setting: Antipsychotics Prescription Patterns and Long-Term Benzodiazepine Use

Frontiers in Psychiatry, 2022
BackgroundMaintenance therapy of patients with primary psychosis spectrum disorders (PSD) in the Western Balkans has received limited interest so far.
Nadja P. Maric, Sanja Andric Petrovic, Manuela Russo, Stefan Jerotic, Ivan Ristic, Bojana Savić, Tamara Pemovska, Milos Milutinovic, Emina Ribic, Silvana Markovska-Simoska, Alma Dzubur Kulenovic, Nikolina Jovanovic   +11 more
doaj   +1 more source

Adverse health events associated with antipsychotic use: an umbrella review [PDF]

, 2022
INTRODUCTION: Antipsychotic medications are prescribed in nearly 800,000 patients in England. Monitoring the adverse effects of antipsychotics is essential in the prevention of harm to patients.
Chow, Rachel Tsz Suet
core   +1 more source