Results 11 to 20 of about 263,171 (350)

Effects of Risperidone and Prenatal Poly I:C Exposure on GABA_A Receptors and AKT-GSK3β Pathway in the Ventral Tegmental Area of Female Juvenile Rats

Biomolecules, 2022
The ventral tegmental area (VTA) in the ventral midbrain is the origin of the dopaminergic neurotransmission pathways. Although GABAA receptors and AKT-GSK3β signaling are involved in the pathophysiology of mental disorders and are modulated by ...
Shiyan Chen, Jiamei Lian, Yueqing Su, Chao Deng   +3 more
doaj   +1 more source

Lipidomics Reveals Early Metabolic Changes in Subjects with Schizophrenia: Effects of Atypical Antipsychotics [PDF]

, 2013
There is a critical need for mapping early metabolic changes in schizophrenia to capture failures in regulation of biochemical pathways and networks.
AA Farooqui, AI Glen, BE Leonard, C Luo, D Cohen, DF Horrobin, DF Horrobin, DP Rice, George G. Dougherty, GP Amminger, Henry A. Nasrallah, HM Rhoades, Hongjie Zhu, Jeffrey K. Yao, JJ Potwarka, JK Yao, JK Yao, JM Kane, Joseph McEvoy, JP McEvoy, JR Hibbeln, K Ohara, KS Dervola, M Arvindakshan, M McSweeney, M Peet, M Strassnig, M Zeman, Matcheri S. Keshavan, MK Gregory, MS Keshavan, MS Keshavan, MS Keshavan, Peter Buckley, R Kaddurah-Daouk, R Kaddurah-Daouk, RA Johnson, RD McQuade, Rebecca A. Baillie, Rima Kaddurah-Daouk, S Mukherjee, S Saddichha, S Sengupta, SH Fatemi, SJ Wood, SM Watkins, SM Watkins, SP Mahadik, T Sumiyoshi, Takeo Yoshikawa, TJ Barrett, TM du Bois, WJ van der Kemp, WP Hoen, Y Benjamini, Y Benjamini, YA Hannun   +56 more
core   +16 more sources

Epigenetic histone acetylation modulating prenatal Poly I:C induced neuroinflammation in the prefrontal cortex of rats: a study in a maternal immune activation model

Frontiers in Cellular Neuroscience, 2022
Introduction: Neuroinflammation in the central nervous system, particularly the prefrontal cortex (PFC), plays a role in the pathogenesis of schizophrenia, which has been found to be associated with maternal immune activation (MIA).
Yueqing Su, Yueqing Su, Yueqing Su, Yueqing Su, Jiamei Lian, Jiamei Lian, Shiyan Chen, Wenchang Zhang, Chao Deng, Chao Deng   +9 more
doaj   +1 more source

Seventy Years of Antipsychotic Development: A Critical Review

Biomedicines, 2023
Since the mid-1950s discovery of the first effective antipsychotic medications (APM), we have only been able to improve the tolerability but not the overall efficacy of currently available APMs, as reflected by effectiveness trials in Europe and the ...
Mujeeb U. Shad
doaj   +1 more source

Comparison of Haloperidol and Quetiapine for Treatment of Delirium in Critical Illness: A Prospective Randomised Double-blind Placebo-controlled Trial [PDF]

Journal of Clinical and Diagnostic Research, 2022
Introduction: Delirium is associated with an increased chance of death, prolonged hospitalisation, higher healthcare costs, and possibly long-term brain damage in survivors.
Rishabah Garg, Vipin Kumar Singh, Pratishruti, GP Singh   +3 more
doaj   +1 more source

A Method for Tapering Antipsychotic Treatment That May Minimize the Risk of Relapse

Schizophrenia bulletin, 2021
The process of stopping antipsychotics may be causally related to relapse, potentially linked to neuroadaptations that persist after cessation, including dopaminergic hypersensitivity.
M. Horowitz, S. Jauhar, S. Natesan, R. Murray, David Taylor   +4 more
semanticscholar   +1 more source

Analgesic Effects of Oxycodone in Combination With Risperidone or Ziprasidone: Results From a Pilot Randomized Controlled Trial in Healthy Volunteers

Frontiers in Pain Research, 2022
Background and ObjectivesPatients taking opioids are at risk of developing dependence and possibly abuse. Given the role of the mesolimbic dopamine system in opioid reward, blocking dopamine D2 receptors should limit the abuse liability of opioid ...
Ameet S. Nagpal, Daniel J. Lodge, Jennifer S. Potter, Alan Frazer, Robin Tragus, Megan E. Curtis, Megan E. Curtis, Angela M. Boley, Maxim Eckmann   +8 more
doaj   +1 more source

Maintenance Therapy of Psychosis Spectrum Disorders in a Real-World Setting: Antipsychotics Prescription Patterns and Long-Term Benzodiazepine Use

Frontiers in Psychiatry, 2022
BackgroundMaintenance therapy of patients with primary psychosis spectrum disorders (PSD) in the Western Balkans has received limited interest so far.
Nadja P. Maric, Sanja Andric Petrovic, Manuela Russo, Stefan Jerotic, Ivan Ristic, Bojana Savić, Tamara Pemovska, Milos Milutinovic, Emina Ribic, Silvana Markovska-Simoska, Alma Dzubur Kulenovic, Nikolina Jovanovic   +11 more
doaj   +1 more source

20‐year follow‐up study of physical morbidity and mortality in relationship to antipsychotic treatment in a nationwide cohort of 62,250 patients with schizophrenia (FIN20)

World Psychiatry, 2020
Antipsychotics are effective in preventing relapses of schizophrenia, but it is generally believed that their long‐term use is harmful for patients’ physical well‐being. However, there are no long‐term studies which have verified this view.
H. Taipale, A. Tanskanen, J. Mehtälä, P. Vattulainen, C. Correll, J. Tiihonen   +5 more
semanticscholar   +1 more source

Antipsychotic Polypharmacy for the Management of Schizophrenia: Evidence and Recommendations

Drugs, 2021
Schizophrenia is a debilitating illness with a lifetime prevalence estimate of 0.6% and consists of symptoms from the positive, negative, and cognitive domains.
M. Lähteenvuo, J. Tiihonen
semanticscholar   +1 more source