Results 41 to 50 of about 41,988 (210)
Boundary‐Dependent Sleep–Wake Dysregulation in Idiopathic Hypersomnia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Idiopathic hypersomnia (IH) presents with excessive daytime sleepiness (EDS) despite apparently preserved nocturnal sleep, challenging traditional models of hypersomnolence based on sleep loss or fragmentation. We aimed to test the hypothesis that EDS in IH reflects excessive stabilization of the sleep state, consistent with ...
Samantha Mombelli +13 more
wiley +1 more source
BJPsych OpenBackground Off-licence psychotropic use in people with intellectual disability and/or autism, in the absence of psychiatric illness, is a major public health concern in England.
Samuel J. Tromans +12 more
doaj +1 more source
Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy
Advanced Science, EarlyView.A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li +11 more
wiley +1 more source
Inhibition of the oncogenic channel Kv10.1 by the antipsychotic drug penfluridol
Frontiers in PharmacologyDrug repurposing is an increasingly recognized strategy in pharmaceutical development that focuses on identifying new therapeutic uses for already approved drugs, as an alternative to the time-consuming and costly process of developing new molecular ...
Paulina León-Sánchez +7 more
doaj +1 more source
Frontiers in Neuroscience, 2011 The lack of predictive in vitro models for behavioral phenotypes impedes rapid advancement in neuropharmacology and psychopharmacology. In vivo behavioral assays are more predictive of activity in human disorders, but such assays are often highly ...
Steven L Roberds +5 more
doaj +1 more source
Neuroimaging glutamatergic mechanisms differentiating antipsychotic treatment-response [PDF]
, 2023 Glutamatergic dysfunction is associated with failure to respond to antipsychotic medication in individuals with schizophrenia. Our objective was to combine neurochemical and functional brain imaging methods to investigate glutamatergic dysfunction and ...
Vanes, Lucy D +5 more
core +1 more source
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source
N-Skatyltryptamines—Dual 5-HT6R/D2R Ligands with Antipsychotic and Procognitive Potential
Molecules, 2021 A series of N-skatyltryptamines was synthesized and their affinities for serotonin and dopamine receptors were determined. Compounds exhibited activity toward 5-HT1A, 5-HT2A, 5-HT6, and D2 receptors.
Agata Hogendorf +13 more
doaj +1 more source
American Journal of Industrial Medicine, EarlyView.ABSTRACT Introduction Accurate assessment of heat strain at initial stay time (IST; core temperature 38.0°C or Δ1.0°C above resting), when heat mitigation decisions are required, is critical for managing occupational heat exposure. We evaluated the relationship and agreement between physiological (Physiological Strain Index [PSI] and adaptive PSI [aPSI]
Gil Bourgois +4 more
wiley +1 more source
Noninvasive drug adherence monitoring of antipsychotic patients via finger sweat testing
Frontiers in Chemistry, 2023 Collection of finger sweat is explored here as a rapid and convenient way of monitoring patient adherence to antipsychotic drugs. Finger sweat samples (n = 426) collected from patients receiving treatment with clozapine, quetiapine and olanzapine were ...
K. Longman +7 more
doaj +1 more source