Results 41 to 50 of about 3,364,808 (342)

Clozapine-induced, dilated cardiomyopathy: a case report

BMC Research Notes, 2017
Background Clozapine is known to be a highly effective antipsychotic agent and additionally provides a significant reduction in suicide-risk and aggression.
Sarah Longhi, Stephan Heres
doaj   +1 more source

An EMG study of the lip muscles during covert auditory verbal hallucinations in schizophrenia [PDF]

, 2013
Purpose: Auditory verbal hallucinations (AVHs) are speech perceptions in the absence of a external stimulation. An influential theoretical account of AVHs in schizophrenia claims that a deficit in inner speech monitoring would cause the verbal thoughts ...
Dohen, Marion, Loevenbruck, Hélène, Perrier, Pascal, Polosan, Mircea, Rapin, Lucile   +4 more
core   +5 more sources

Sex differences in plasma clozapine and norclozapine concentrations in clinical practice and in relation to body mass index and plasma glucose concentrations: a retrospective survey [PDF]

, 2015
Background Clozapine is widely prescribed and, although effective, can cause weight gain and dysglycemia. The dysmetabolic effects of clozapine are thought to be more prevalent in women with this gender on average attaining 17 % higher plasma clozapine ...
Anderson, Simon G., Connolly, Moira, Couchman, Lewis, Flanagan, Robert J., Heald, A. H., Livingston, Mark, Miller, Joan, Smith, Daniel J.   +7 more
core   +2 more sources

Older patients' prescriptions screening in the community pharmacy: development of the Ghent Older People's Prescriptions community Pharmacy Screening (GheOP3S) tool [PDF]

, 2015
Background: Ageing of the population often leads to polypharmacy. Consequently, potentially inappropriate prescribing (PIP) becomes more frequent. Systematic screening for PIP in older patients in primary care could yield a large improvement in health ...
Boussery, Koen, Mehuys, Els, Petrovic, Mirko, Somers, Annemie, Tommelein, Eline, van der Cammen, Tischa   +5 more
core   +7 more sources

Identification of Trypanosoma cruzi Polyamine Transport Inhibitors by Computational Drug Repurposing [PDF]

, 2019
Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. In T. cruzi the transport of polyamines is essential because this organism is unable to synthesize these compounds de novo.
Martínez Sayé, Melisa Soledad, Miranda, Mariana Reneé, Pereira, Claudio Alejandro, Phanstiel, Otto, Reigada, Chantal, Valera Vera, Edward Augusto   +5 more
core   +1 more source

Uncovering the Lipid Interface in Neurotransmission: Single Molecule Measurements of Neurotransmitters Interacting with Membranes Reveal Species Dependent Membrane Binding

Advanced Science, EarlyView.
Using single‐molecule whispering gallery mode sensors, neurotransmitter‐specific membrane binding signatures are measured that reveal intrinsically distinct interaction kinetics and orientations on a lipid membrane. Abstract Neurotransmitters (NTs) have traditionally been understood to act via aqueous‐phase receptor binding, but growing evidence ...
Thomas L. Derrien, Aneeth Kakkanattu Arunkumar, Rosalind Cross, Emilie Sunnucks, Frank Vollmer   +4 more
wiley   +1 more source

Parkinsonian motor impairment predicts personality domains related to genetic risk and treatment outcomes in schizophrenia [PDF]

, 2017
Identifying endophenotypes of schizophrenia is of critical importance and has profound implications on clinical practice. Here we propose an innovative approach to clarify the mechanims through which temperament and character deviance relates to risk for
Alemán, Gabriela González, Balda, Mara, Bourdieu, Mercedes, Calvó, María, Cloninger, C. Robert, Conesa, Horacio A, de Erausquin, Gabriel A, Escobar, Javier I, Florenzano, Néstor V, Guerrero, Gonzalo, Kamis, Danielle, Molina, Juan L, Padilla, Eduardo, Rangeon, Beatriz Molina, Strejilevich, Sergio A, Zwir, Igor   +15 more
core   +2 more sources

The persistence of chronic opioid use in patients with inflammatory bowel disease—A nationwide cohort study

British Journal of Clinical Pharmacology, EarlyView.
Aims Pain is common in patients with Crohn's disease (CD) and ulcerative colitis (UC), and a substantial proportion develop chronic opioid use (COU). We examined the persistence of COU over time and identified factors predicting persistent use. Methods This nationwide Danish cohort study included patients with an initial period of COU (definition: ≥3 ...
Bente Mertz Nørgård, Caroline Theilgaard Thorarinsson, Jan Nielsen, Mette Louise Andersen, Jens Kjeldsen, Torben Knudsen, Rahul S. Dalal   +6 more
wiley   +1 more source

Innovative Drug Delivery and Formulation Designs To Deter Drug Abuse/Misuse Related To Suicide [PDF]

, 2012
Patients with a history of abuse/misuse of pain and psychotic medications are at high risk for suicide. Novel drug delivery and formulation approaches have been explored to reduce the potential of drug abuse/misuse and to improve patient compliance. This
Zhao, Fang
core   +1 more source

G4.5 Pamam Dendrimer-Risperidone: Biodistribution and Behavioral Changes in In Vivo Model [PDF]

, 2013
Dendritic polymers are considered as emerging and outstanding carriers as modern medicinal systems due to their derivatisable branched architecture and possibility to modify them in numerous ways.
Alonso, Silvia del Valle, Bichara, Darío Román, Chiaramoni, Nadia Silvia, del Rio Zabala, Nahuel Eduardo, Marotta, Cristian Hernán, Prieto, Maria Jimena, Simonetta, Sergio Hernan   +6 more
core   +2 more sources