Results 221 to 230 of about 3,281,120 (365)

Medical Knowledge Integration Into Reinforcement Learning Algorithms for Dynamic Treatment Regimes

International Statistical Review, EarlyView.
Summary The goal of precision medicine is to provide individualised treatment at each stage of chronic diseases, a concept formalised by dynamic treatment regimes (DTR). These regimes adapt treatment strategies based on decision rules learned from clinical data to enhance therapeutic effectiveness.
Sophia Yazzourh, Nicolas Savy, Philippe Saint‐Pierre, Michael R. Kosorok   +3 more
wiley   +1 more source

Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors.

Journal of Pharmacology and Experimental Therapeutics, 1994
B. Roth, S. Craigo, M. S. Choudhary, A. Uluer, F. Monsma, Y. Shen, H. Meltzer, D. Sibley   +7 more
semanticscholar   +1 more source

Advancing evidence‐based practice through the Knowledge Translation Challenge: Nurses’ important roles in research, implementation science and practice change

Journal of Advanced Nursing, EarlyView.
Abstract Aim To describe a knowledge translation capacity‐building initiative and illustrate the roles of nurses in practice change using an exemplar case study. Design The report uses observational methods and reflection. Methods The Knowledge Translation Challenge program involves a multi‐component intervention across several sites.
Amanda Chisholm, Angela Russolillo, Michelle Carter, Marla Steinberg, Leah Lambert, Andrea Knox, Agnes Black   +6 more
wiley   +1 more source

Individual and Institutional Factors Associated With Urinary Incontinence Among Nursing Home Residents: A Multilevel Analysis

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aims (1) To analyse individual and institutional‐level factors associated with urinary incontinence in older adults living in nursing homes; (2) to estimate the prevalence of urinary, faecal and double incontinence in nursing home residents. Design Cross‐sectional study. Methods Residents aged 65+ living in 22 nursing homes in Catalonia (Spain)
Javier Jerez‐Roig, Nayara Priscila Dantas de Oliveira, Pau Moreno‐Martin, Júlia Casacuberta‐Roca, Dyego Leandro Bezerra de Souza, Ester Goutan‐Roura, Laura Coll‐Planas, Adrian Wagg, William Gibson, Xavier Gómez‐Batiste   +9 more
wiley   +1 more source

Patient Agitation in the Intensive Care Unit: A Concept Analysis

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim Exploring the concept of patient agitation in the intensive care unit. Background Patient agitation in the intensive care unit is of widespread concern and linked to negative outcomes for patients, staff, and family members. There is currently no consensus on what constitutes agitation in the intensive care context, hindering effective and
Anne Mette N. Adams, Diane Chamberlain, Charlotte Brun Thorup, Matthew J. Maiden, Cherie Waite, Hila Ariela Dafny, Kay Bruce, Tiffany Conroy   +7 more
wiley   +1 more source

Palliative Care for People With Very Severe to Extreme Behavioural and Psychological Symptoms of Dementia (BPSD): A Scoping Review

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To explore current evidence regarding the provision of palliative care for individuals with very severe to extreme behavioural and psychological symptoms of dementia (BPSD) in a hospital setting. Design Scoping review. Reporting Method The PRISMA‐ScR reporting guideline. Methods The JBI guidelines for scoping reviews were followed.
Maree Gallop, Jenny Ford, Alexandra Bowman, Antony Mullen, Debbie Schwebel, Amanda Johnson, Ritin Fernandez   +6 more
wiley   +1 more source

Movement Disorders in Elderly Users of Risperidone and First Generation Antipsychotic Agents: A Canadian Population-Based Study

, 2013
Irina Vasilyeva, Robert G. Biscontri, Murray W. Enns, Colleen Metge, Silvia Alessi‐Severini   +4 more
openalex   +2 more sources

Annual Research Review: Psychosis in children and adolescents – a call to action: a commentary on Kelleher (2025)

Journal of Child Psychology and Psychiatry, Volume 66, Issue 4, Page 588-591, April 2025.
The spectrum of psychosis is highly relevant to child and adolescent mental health. Psychotic symptoms are common in children and adolescents. The onset of psychotic disorders is often preceded by neurodevelopmental problems in early childhood, and some 13% of adolescents attending specialist mental health services will later be diagnosed with a ...
James G. Scott
wiley   +1 more source

Comparative Safety of Medications for Severe Agitation: A Geriatric Emergency Department Guidelines 2.0 Systematic Review

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Managing undifferentiated, severe agitation in older adults may require antipsychotic or sedative medications to prevent harm to self or others. Unfortunately, these medications are associated with serious adverse events in older adults, and little is known about their comparative safety.
Martin F. Casey, Natalie M. Elder, Alexander Fenn, Joshua Niznik, Danya Khoujah, Jon B. Cole, Zachary Cardon, Ming Ding, Naira Goukasian, Elizabeth Moreton, Jennifer L. Koehl, Phillip D. Magidson, Rachel M. Skains, Katren Tyler, Shan W. Liu, on behalf of the Geriatric Emergency Department Guidelines Medication Safety Group, Jane M. Hayes, Katherine Selman, Phraewa Thatphet, Kazuki Toda, Bryan D. Hayes, Sangil Lee   +21 more
wiley   +1 more source

Treatment of Inappropriate Sexual Behavior in Persons With Dementia: A Systematic Review

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Inappropriate sexual behavior (ISB), such as sexual touching and sexual exposure, occurs in up to 25% of people with dementia. This systematic review examines the effectiveness of pharmacologic and non‐pharmacologic interventions to manage ISB in persons with dementia.
Natasha E. Lane, Manan Ahuja, Stacey Hatch, Dallas P. Seitz, Jessie McGowan, Jennifer A. Watt   +5 more
wiley   +1 more source