Results 271 to 280 of about 3,264,242 (368)

Glutamate-Based Therapeutic Strategies for Schizophrenia: Emerging Approaches Beyond Dopamine. [PDF]

Int J Mol Sci
Fadgyas-Stanculete M, Capatina OO.
europepmc   +1 more source

Impact of Drug–Drug Interactions on Clinical Outcomes in Metastatic Melanoma Patients Treated With Combined BRAF/MEK Inhibitors: A Real‐World Study

Pigment Cell &Melanoma Research, Volume 38, Issue 4, July 2025.
ABSTRACT The unique pharmacokinetics of BRAF and MEK inhibitors make patients vulnerable to drug–drug interactions (DDIs), which may compromise treatment efficacy in metastatic melanoma. This study evaluates the impact of DDIs on clinical outcomes in patients with metastatic melanoma treated with BRAF/MEK inhibitors.
Silvia Mezi, Andrea Botticelli, Giulia Pomati, Simone Scagnoli, Giulia Fiscon, Federica de Galitiis, Francesca Romana di Pietro, Sofia Verkhovskaia, Sasan Amirhassankhani, Giovanna Gentile, Maurizio Simmaco, Bjoern Gohlke, Robert Preissner, Daniele Santini, Paolo Marchetti   +14 more
wiley   +1 more source

Heterogeneous treatment effects of GLP‐1RAs and SGLT2is on risk of Alzheimer's disease and related dementia in patients with type 2 diabetes: Insights from a real‐world target trial emulation

Alzheimer's &Dementia, Volume 21, Issue 6, June 2025.
Abstract INTRODUCTION This study assessed the heterogeneous treatment effects (HTEs) of glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) and sodium‐glucose cotransporter‐2 inhibitors (SGLT2is) on the risk of Alzheimer's disease and related dementias (ADRD). METHODS This target trial emulation study included adults (≥ 50 years) with type 2 diabetes (
Huilin Tang, William T. Donahoo, Steven T. DeKosky, Yao An Lee, Pareeta Kotecha, Mikael Svensson, Jiang Bian, Jingchuan Guo   +7 more
wiley   +1 more source

Associations between clozapine availability, the diagnosis of treatment-resistant schizophrenia subgroups, antipsychotic monotherapy, and concomitant psychotropics among patients with schizophrenia: a real-world nationwide study. [PDF]

Int J Neuropsychopharmacol
Ochi S, Kodaka F, Hasegawa N, Tsuboi T, Ohi K, Igarashi S, Fukumoto K, Iga JI, Muraoka H, Iida H, Tagata H, Kashiwagi H, Numata S, Yamagata H, Takeshima M, Ichihashi K, Hashimoto N, Nagasawa T, Nakamura T, Matsumoto J, Yamada H, Hori H, Ueno SI, Inada K, Hashimoto R, Yasui-Furukori N.   +25 more
europepmc   +1 more source

A qualitative report on metacognitive training (MCT) for people with schizophrenia

Counselling and Psychotherapy Research, Volume 25, Issue 2, June 2025.
Abstract Objective Metacognitive training (MCT) for psychosis is a psychological intervention that blends cognitive behavioural therapy and psychoeducation. Several published systematic reviews and meta‐analyses have provided robust evidence of its efficacy.
Vanessa Acuña, María Guerra, Orlando Toledo, Matías Cobaisse, Javier Silva, Álvaro Cavieres   +5 more
wiley   +1 more source

Antipsychotic Polypharmacy for Treatment Resistant Schizoaffective Disorder: A Case Report. [PDF]

Cureus
Moriarty SE, Parhami P, Parikh J, Galicki L.   +3 more
europepmc   +1 more source

Water Intoxication Caused by an Overdose of Powdered Herbal Medicine: A Case Report

Clinical Case Reports, Volume 13, Issue 6, June 2025.
ABSTRACT Large doses of powdered herbal medicines can cause water intoxication due to excessive water intake. Clinicians should consider this risk alongside the medicine's side effects for timely diagnosis and management.
Yukari Maki, Asuka Tsuchiya, Seiji Morita, Yoshihide Nakagawa   +3 more
wiley   +1 more source

Exploring the Relationship Between Antipsychotic Drug Target Genes and Epilepsy: Evidence From Food and Drug Administration Adverse Event Reporting System Database and Mendelian Randomization. [PDF]

Brain Behav
Yin Z, Zhan Z, Qiu Y, Wang M, Li J, Song B, Chen Z, Wu J, Wang Z.   +8 more
europepmc   +1 more source

Drug‐Event Pairs as Indicators for the Detection of Adverse Drug Reactions during Hospitalization in Routinely Collected Electronic Data Sources

Clinical Pharmacology &Therapeutics, Volume 117, Issue 6, Page 1811-1819, June 2025.
Adverse drug reactions (ADRs) are a common cause of morbidity and mortality in hospitalized patients. Identification of ADRs in clinical practice, surveillance and research is essential to prevent further harm. The aim of this study was to assess the likelihood of drugs contributing to clinically important inpatient adverse events, in order to provide ...
Anna Maria Wermund, Annette Haerdtlein, Wolfgang Fehrmann, Clara Weglage, Tobias Dreischulte, Ulrich Jaehde   +5 more
wiley   +1 more source

The association between STOPPFall medication use and falls and fractures in community-dwelling older people. [PDF]

Age Ageing
Doyle K, Scarlett S, Knight SP, Moriarty F, Lavan A, Kenny RA, Briggs R.   +6 more
europepmc   +1 more source