Results 311 to 320 of about 3,264,242 (368)
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Clozapine: A Novel Antipsychotic Agent
DICP, 1989Clozapine is an antipsychotic without the extrapyramidal adverse effects associated with currently marketed antipsychotics. In animals, this drug has not been shown to induce catalepsy and only weakly antagonizes the stereotypic movements induced by apomorphine and the amphetamines.
Richard L. Wagner +2 more
openaire +3 more sources
Off-label use of second-generation antipsychotic agents among elderly nursing home residents.
Psychiatric Services, 2010OBJECTIVE This study examined off-label and evidence-based use of second-generation antipsychotic agents among elderly nursing home residents and factors associated with off-label use.
P. Kamble +3 more
semanticscholar +1 more source
Journal of Clinical Psychiatry, 2010
OBJECTIVE To compare the risk of cerebrovascular adverse events with second-generation antipsychotic users versus those taking first-generation antipsychotics in community-dwelling older adults.
S. Mehta +3 more
semanticscholar +1 more source
OBJECTIVE To compare the risk of cerebrovascular adverse events with second-generation antipsychotic users versus those taking first-generation antipsychotics in community-dwelling older adults.
S. Mehta +3 more
semanticscholar +1 more source
Journal of Clinical Psychiatry, 2010
CONTEXT In the Clinical Antipsychotic Trials of Intervention Effectiveness, atypical antipsychotics (AAPs) were found to be associated with weight gain and impairment of glucose metabolism.
M. Ehret +3 more
semanticscholar +1 more source
CONTEXT In the Clinical Antipsychotic Trials of Intervention Effectiveness, atypical antipsychotics (AAPs) were found to be associated with weight gain and impairment of glucose metabolism.
M. Ehret +3 more
semanticscholar +1 more source
New England Journal of Medicine, 1991
This review considers the discovery of clozapine; its chemistry, pharmacologic activities, metabolism, and pharmacokinetics; evidence of its efficacy; and its side effects and appropriate clinical ...
John A. Oates +3 more
openaire +3 more sources
This review considers the discovery of clozapine; its chemistry, pharmacologic activities, metabolism, and pharmacokinetics; evidence of its efficacy; and its side effects and appropriate clinical ...
John A. Oates +3 more
openaire +3 more sources
Antipsychotic to anticancer agent?
Nature Reviews Cancer, 2012A new study shows that a clinically approved drug might selectively target cancer stem cells for differentiation.
openaire +5 more sources
Journal of Clinical Psychiatry, 2009
OBJECTIVE Although atypical antipsychotic agents have been found effective in the augmentation of serotonin reuptake inhibitors (SRIs) for treatment-resistant obsessive-compulsive disorder (OCD) in short-term trials, there are few data on the ...
H. Matsunaga +5 more
semanticscholar +1 more source
OBJECTIVE Although atypical antipsychotic agents have been found effective in the augmentation of serotonin reuptake inhibitors (SRIs) for treatment-resistant obsessive-compulsive disorder (OCD) in short-term trials, there are few data on the ...
H. Matsunaga +5 more
semanticscholar +1 more source
Psychiatric Services, 2008
OBJECTIVE Medicaid expenditures for antipsychotic medications have risen rapidly, from under $1.0 billion in 1995 to over $5.5 billion in 2005. In response, at least ten states have implemented prior-authorization programs that restrict access to ...
M. Law, D. Ross-Degnan, S. Soumerai
semanticscholar +1 more source
OBJECTIVE Medicaid expenditures for antipsychotic medications have risen rapidly, from under $1.0 billion in 1995 to over $5.5 billion in 2005. In response, at least ten states have implemented prior-authorization programs that restrict access to ...
M. Law, D. Ross-Degnan, S. Soumerai
semanticscholar +1 more source
Utilization and costs of antipsychotic agents: a Canadian population-based study, 1996-2006.
Psychiatric Services, 2008OBJECTIVE This study evaluated the prescribing patterns and costs for antipsychotic agents in the population of the Canadian province of Manitoba over the past decade.
S. Alessi-Severini +5 more
semanticscholar +1 more source
Toxicology of Antipsychotic Agents
1980The introduction of chlorpromazine and reserpine for psychiatric use has been followed by a steady increase in the number of psychotropic agents. In the development of new compounds, there have been many attempts to improve the therapeutic indices and to vary the profile of pharmacodynamic activity in accordance with clinical requirements.
F. Leuschner, R. Hempel, W. Neumann
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