Results 91 to 100 of about 16,628 (221)

Pharmacology and relevant drug interactions of metamizole

British Journal of Clinical Pharmacology, Volume 91, Issue 7, Page 2095-2102, July 2025.
Metamizole is a frequently prescribed analgesic because of its favourable benefit/risk ratio compared with classic NSAIDs. However, increasing research shows that metamizole displays several drug interactions that are relevant to clinical practice. We reviewed the literature to summarize the pharmacology and most clinically relevant drug interactions ...
David J. Brinkman, Linda C. Hendriksen, Irma M. Rigter, Markus W. Hollmann   +3 more
wiley   +1 more source

Characteristics of patients with difficult-to-treat rheumatoid arthritis: a descriptive retrospective cohort study

Advances in Rheumatology
Background In 2021, an EULAR task force published a definition of difficult-to-treat rheumatoid arthritis (D2T RA). Our current knowledge of D2T RA with the EULAR definition is based on European and Asian cohorts, and no North American cohort has yet to ...
Wen Qi, Antoine Robert, Narcisse Singbo, Lucie Ratelle, Paul R. Fortin, Louis Bessette, Jacques P. Brown, Laëtitia Michou   +7 more
doaj   +1 more source

Chemical Components of the Dried Latex of Euphorbia resinifera Berg and Its Medicinal Features

Chemistry &Biodiversity, Volume 22, Issue 7, July 2025.
ABSTRACT A great deal of research has been carried out on the latex of Euphorbia resinifera Berg, which is an important source of several compounds of therapeutic and medicinal interest. Extraction, synthesis, and hemi synthesis pathways continue to reveal the existence of other new products with anticancer, antioxidant, antidiuretic, and antimalarial ...
Doaa Hammad, El‐Mahdi Ourhzif, Salha Hamri, Hafid Abderrafia, Mostafa Khouili, Maria Dolors Pujol   +5 more
wiley   +1 more source

Polypharmacy independently predicts survival, hospitalization, and infections in patients with lymphoid cancer

HemaSphere, Volume 9, Issue 7, July 2025.
Abstract Polypharmacy is a result of multimorbidity and may limit treatment options in patients with lymphoid cancer (LC). To investigate the clinical impact of polypharmacy, we gathered a prediagnostic 1‐year medication history from the Danish prescription register for 46,803 newly diagnosed patients with six lymphoma subtypes, chronic lymphocytic ...
Christian Brieghel, Thomas Lacoppidan, Esben Packness, Casper Møller Frederiksen, Mikkel Werling, Michael Asger Andersen, Christian Bjørn Poulsen, Emelie Curovic Rotbain, Carsten Utoft Niemann   +8 more
wiley   +1 more source

A Novel Dual Bruton's Tyrosine Kinase/Janus Kinase 3 Inhibitor Wj1113 and its Therapeutic Effects on Rheumatoid Arthritis

MedComm, Volume 6, Issue 7, July 2025.
Wj1113 simultaneously inhibits the JAK3 and BTK pathways, impacting the activation of macrophages and B cells, as well as influencing monocyte chemotaxis. Consequently, this results in a decrease in proinflammatory factors such as MCP‐1(monocyte chemoattractant protein‐1), G‐CSF(granulocyte colony‐stimulating factor), IL‐6, TNF‐α, and RANTS(regulated ...
Chunyu Zhang, Fangfang Lai, Hang Gong, Shuying Li, Nan Xiang, Liuyi Que, Nina Xue, Mengyao Hao, Enjia Zhou, Xiaojian Wang, Taigang Liang, Jing Jin   +11 more
wiley   +1 more source

Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth [PDF]

, 2014
Ningning Liu, Xiaofen Li, Hongbiao Huang, Chong Zhao, Siyan Liao, Changshan Yang, Shouting Liu, Wenbin Song, Xiaoyu Lu, Xiaoying Lan, Xin Chen, Songgang Yi, Li Xu, Lili Jiang, Canguo Zhao, Xiaoxian Dong, Ping Zhou, Shujue Li, Shunqing Wang, Xianping Shi, Q. Ping Dou, Xuejun Wang, Jinbao Liu   +22 more
openalex   +1 more source

Autoimmune Diseases: Molecular Pathogenesis and Therapeutic Targets

MedComm, Volume 6, Issue 7, July 2025.
This review provides a comprehensive overview of common autoimmune diseases, details clinical manifestations and summarizes the pathogenesis, including the breakdown of immune tolerance, initiation of autoimmune responses, and their progressive amplification.
Xiaoshuang Song, Hantian Liang, Fang Nan, Wenjing Chen, Junyao Li, Liu He, Yiping Cun, Zhenhong Li, Wei Zhang, Dunfang Zhang   +9 more
wiley   +1 more source

Sjögren's Syndrome: Epidemiology, Classification Criteria, Molecular Pathogenesis, Diagnosis, and Treatment

MedComm, Volume 6, Issue 7, July 2025.
A brief view of possible etiologic events preceding the diagnosis of desiccation syndrome. ABSTRACT Sjögren's syndrome (SS) is a chronic autoimmune disorder characterized by T‐cell‐mediated B‐cell hyperactivity and cytokine production, clinically manifesting, dry mouth and eyes, accompanied by pain and fatigue.
Ying Hu, Bin Wen, Yunfei Zhang, Xiaocui Wang, Xuemei Duan, Haonan Li, Yufeng Fan, Huifeng Shang, Yukai Jing   +8 more
wiley   +1 more source

The Effects of Tocilizumab on Inflammatory and Differentiation Pathways in Primary Human Chondrocytes: A Bioinformatic and In Vitro Approaches

International Journal of Rheumatic Diseases, Volume 28, Issue 7, July 2025.
ABSTRACT Introduction This study investigates the effects of Tocilizumab, an interleukin‐6 (IL‐6) receptor inhibitor, on human primary chondrocyte cells, focusing on bone morphogenetic protein 2 (BMP‐2), hypoxia‐inducible factor 1‐alpha (HIF‐1α), interleukin‐1 beta (IL‐1β), SRY‐box transcription factor 9 (SOX‐9), and IL‐6 genes.
Bugrahan Regaip Kilinc, Feyza Kostak, Omer Faruk Yilmaz, Suray Pehlivanoglu, Duygu Yasar Sirin   +4 more
wiley   +1 more source

FRI0221 Does seropositivity influence differentially drug discontinuation of biologic antirheumatic agents with non-anti-tnf mode of action? [PDF]

, 2017
Axel Finckh, D. Courvoisier, J.E. Gottenberg, Xavier Mariette, Jacques Morel, Sytske Anne Bergstra, Victoria Hernández, Cătălin Codreanu, T.K. Kvien, María José Santos, Karel Pavelká, Merete Lund Hetland, Katerina Chatzidionysiou, Johan Askling, Carl Turesson, Cem Gabay, Ronald van Vollenhoven   +16 more
openalex   +1 more source