Results 111 to 120 of about 19,125 (215)

Use of a Molecular Signature Response Classifier to Inform Treatment Selection Improves Clinical Disease Activity Among Patients with Rheumatoid Arthritis Initiating a Biologic or Targeted Synthetic Disease‐Modifying Antirheumatic Drug

Arthritis Care &Research, Volume 78, Issue 9, Page 1149-1158, September 2026.
Objective We assessed the effectiveness of PrismRA to improve clinical outcomes among patients with rheumatoid arthritis (RA) initiating treatment with a biologic or targeted synthetic disease‐modifying antirheumatic drug (b/tsDMARD). Methods PrismRA incorporated 19 gene expression features and four clinical features to assess a patient's likelihood of
Fenglong Xie, Timothy Beukelman, Nicholas P. McCormick, Jeffrey R. Curtis   +3 more
wiley   +1 more source

Pharmacokinetics and Tissue Distribution in Rats After Oral Administration of Tibetan Medicine Wuwei Leze Powder

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Wuwei Leze Powder (WLP), a classic Tibetan medicine for rheumatoid arthritis, is orally administered and undergoes extensive absorption and metabolism in rats. A total of 56 plasma constituents, including 21 prototypes and 35 metabolites, are identified.
Ping Wang, Peng Wang, YiRui Wu, ShuiYing Wu, HuiJuan Xu, WenYu Yang, Ya Tu, Chuan Liu   +7 more
wiley   +1 more source

Clerodendrum japonicum Extract Suppresses the Pathogenicity of Rheumatoid Arthritis Fibroblast‐Like Synoviocytes by Inhibiting METTL3‐Mediated ICAM2 mRNA Methylation

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Clerodendrum japonicum (Thunb.) Sweet (Clerodendrum japonicum) is a traditional medicinal plant with reported anti‐inflammatory use, but its anti‐rheumatoid arthritis (RA) activity and molecular basis remain insufficiently characterized. Activated fibroblast‐like synoviocytes (FLSs) contribute to persistent inflammation and joint destruction ...
Ying Huang, JiangCun Wei, Yan Ma, XiaoPing Mei, MingTao Huang, Liang Lu, JianLong Zhou, ZuJie Qin   +7 more
wiley   +1 more source

Ten‐Year Public Expenditure Savings Associated with TNF Inhibitor Biosimilars under Australia's Pharmaceutical Benefits Scheme

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 684-691, September 2026.
Biologic therapies are a major and growing driver of pharmaceutical expenditure globally, with tumor necrosis factor (TNF) inhibitors among the most widely used and costly biologics. In Australia, these therapies are funded through the Pharmaceutical Benefits Scheme (PBS), where biosimilars offer lower cost alternatives; however, the long‐term public ...
Chin Hang Yiu, Bella D. Ianni, Richard O. Day, Jacques Raubenheimer, Christine Y. Lu   +4 more
wiley   +1 more source

NEW GUIDELINES FOR THE MANAGEMENT OF RHEUMATOID ARTHRITIS (EULAR, 2013): THE PLACE OF GLUCOCORTICOIDS

Научно-практическая ревматология, 2016
Despite major advances in the management of rheumatoid arthritis (RA), whicare associated with the development of new methods for its early diagnosis, the clinical introduction of a wide range of innovative medications and particularly the improvement of
E. L. Nasonov
doaj  

Autoimmunity: Molecular Mechanisms, Biomarkers, and Therapeutic Opportunities

MedComm, Volume 7, Issue 9, September 2026.
Major types of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming involved in autoimmune diseases. The roles of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming in autoimmune diseases have been a major research focus in recent years.
Jialong Kuang, Yin Zhu, Fang Xu, Yongjing Liu, Yuan Li, Ling Yuan, Liqin Wei, Bo Huang, Yan Chen, Pei Huang, Zuochen Du   +10 more
wiley   +1 more source

Tissue‐Resident Macrophage in Inflammation and Cancer

MedComm, Volume 7, Issue 9, September 2026.
Opposing macrophage functions in inflammation and cancer converge on shared mechanistic nodes, informing cross‐disease therapeutic strategies. ABSTRACT Tissue‐resident macrophages (TRMs) are long‐lived immune cells strategically distributed across organs, where their functional plasticity enables both homeostatic maintenance and pathological ...
Siyuan Huang, Jiangbo Fan, Wenyi Liu, Di Liu, Rui Wang, Yuanyang Wang, Jianhui Sun, Huacai Zhang, Qingli Cai, Zhe Xu, Fang Xu, Jianxin Jiang, Zhen Wang, Ling Zeng   +13 more
wiley   +1 more source

Impact of Withdrawal of Extended‐Release Morphine 5 mg on Hospital Analgesic Utilization

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
Mille Vraa Gamborg Eisenhardt, Maja Beck Mejlholm, Lisa Greve Routhe, Anne Estrup Olesen, Astrid Johannesson Hjelholt   +4 more
wiley   +1 more source

Trends in Medicines Discontinuation and Implications for Access in Brazil (2014–2024)

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 9, September 2026.
ABSTRACT Purpose The World Health Organization (WHO) began recognizing drug shortages as a global issue in 2014, impacting health systems and patient care. Shortages arise from supply chain disruptions, production issues, and mismatches between supply and demand, aggravated by insufficient mechanisms for forecasting and communication. Methods The study
Raphaella Oliveira Martins de Lima, Esther Ramos Silva, Isabel C. M. Emmerick, Danielle Maria de Souza Serio dos Santos, Isabella Piassi Dias Godói, Ana Cristina Viana Campos, Luisa Arueira Chaves   +6 more
wiley   +1 more source

Pediatric Use of Off‐Label Medicines and Nonevidence‐Based Supplements for COVID‐19: Findings From the 2015 Pelotas Birth Cohort Study (Brazil)

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 9, September 2026.
ABSTRACT Purpose Pediatric off‐label medicine use increased during the COVID‐19 pandemic, exposing children to nonevidence‐based treatments. We described the use of nonevidence‐based COVID‐19 medicines and supplements among children from the 2015 Pelotas Birth Cohort, according to sociodemographic and health‐related characteristics.
Andréa Dâmaso Bertoldi, Fernando Silva Guimarães, Alexandra Crispim Boing, Marysabel Pinto Telis Silveira, Pedro Curi Hallal, Mariângela Freitas da Silveira   +5 more
wiley   +1 more source